|
Symbol Name ID |
Pcx
pyruvate carboxylase MGI:97520 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased serum pyruvate |
Hyperalaninemia |
Hypoglycemia |
Increased circulating lactate concentration |
Lactic acidosis |
Proximal renal tubular acidosis |
| Disease(s) Associated with PC | ||||||
| pyruvate carboxylase deficiency disease |
| Mouse Phenotypes | abnormal fatty acid oxidation |
abnormal insulin secretion |
decreased fasting circulating glucose level |
decreased circulating glucose level |
hypoglycemia |
increased circulating ketone body level |
increased circulating lactate level |
increased circulating free fatty acids level |
increased circulating triglyceride level |
decreased respiratory quotient |
impaired gluconeogenesis |
improved glucose tolerance |
abnormal insulin clearance |
increased liver triglyceride level |
abnormal amino acid metabolism |
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| Availability | Mouse Genotype | |||||||||||||||
| Pcxtm1b(EUCOMM)Wtsi/Pcx+ | ||||||||||||||||
| Pcxtm1c(EUCOMM)Wtsi/Pcxtm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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