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Pcsk2
Gene Detail
Symbol

Name
ID
Pcsk2
proprotein convertase subtilisin/kexin type 2
MGI:97512
Synonyms
6330411F23Rik, Nec2, Nec-2, PC2, Phpp-2, prohormone convertase 2, SPC2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
70.89 cM, cytoband F3-H2
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr2:143546156-143816285 bp, + strand
From VEGA annotation of GRCm38

  270130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37640  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PCSK2
Protein SuperFamily: proprotein convertase, subtilisin/kexin type
Gene Tree: Pcsk2

Human
homologs
PCSK2, proprotein convertase subtilisin/kexin type 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5126
neXtProt AC: NX_P16519

Human Synonyms: NEC2, NEC 2, NEC-2, PC2, SPC2

Human Chr (Location): 20p11.2; chr20:17226107-17484578 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions of this gene display abnormalities in the maturation of peptide hormones leading to reduced female fertility, increased blood pressure on a high salt diet, and abnormal glucose metabolism.
 
Interactions
Pcsk2 interacts with 334 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process enkephalin processing, insulin processing, ...
Component cytoplasmic vesicle, dendrite, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (12)    Tissues (11)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 2
RT-PCR 6
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pcsk2 ; ZFIN pcsk2    NEW 
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000003089 (Evidence)
Ensembl Gene Model ENSMUSG00000027419 (Evidence)
Entrez Gene 18549 (Evidence)
DFCI TC1572810, TC1608558, TC1692013
DoTS DT.40158276, DT.94124045
NIA Mouse Gene Index U043909, U336939
EC 3.4.21.94
Consensus CDS Project CCDS16810.1
International Mouse Phenotyping Consortium Status Pcsk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003089 VEGA Gene Model | MGI Sequence Detail 270130 C57BL/6J ±  kb
transcript OTTMUST00000006367 VEGA | MGI Sequence Detail 4723 Not Applicable 
polypeptide OTTMUSP00000002995 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(3) : SNPs within 2kb(3723 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000209 Peptidase S8/S53 domain
InterPro IPR023827 Peptidase S8, subtilisin, Asp-active site
InterPro IPR022398 Peptidase S8, subtilisin, His-active site
InterPro IPR015500 Peptidase S8, subtilisin-related
InterPro IPR023828 Peptidase S8, subtilisin, Ser-active site
InterPro IPR002884 Proprotein convertase, P
InterPro IPR009020 Proteinase inhibitor, propeptide
Protein Ontology PR:000012435 neuroendocrine convertase 2
References
(Earliest) J:10744 Seidah NG, et al., cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases [published erratum appears in DNA Cell Biol 1990 Dec;9(10):789]. DNA Cell Biol. 1990 Jul-Aug;9(6):415-24
(Latest) J:206319 Welcker JE, et al., Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013 Dec;140(24):4947-58
All references(115)
Other
accession IDs
MGD-MRK-12803, MGD-MRK-12805, MGD-MRK-13192, MGD-MRK-13300, MGI:1918009, MGI:2139063

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory