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Pck1 Gene Detail
Summary
  • Symbol
    Pck1
  • Name
    phosphoenolpyruvate carboxykinase 1, cytosolic
  • Synonyms
    Pck-1, PEPCK
  • Feature Type
    protein coding gene
  • IDs
    MGI:97501
    NCBI Gene: 18534
  • Gene Overview
    MyGene.info: PCK1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:173153073-173159254 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.79 cM, cytoband C1-qter
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97501
protein coding gene Chr2:173153048-173159273 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026954
protein coding gene Chr2:179405004-179412615 (+)
A/J MGP_AJ_G0026921
protein coding gene Chr2:171862873-171869054 (+)
AKR/J MGP_AKRJ_G0026892
protein coding gene Chr2:177048572-177054801 (+)
BALB/cJ MGP_BALBcJ_G0026930
protein coding gene Chr2:172263121-172269413 (+)
C3H/HeJ MGP_C3HHeJ_G0026672
protein coding gene Chr2:177439568-177445793 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027377
protein coding gene Chr2:184574656-184580749 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024747
protein coding gene Chr2:165099072-165105322 (+)
CAST/EiJ MGP_CASTEiJ_G0026130
protein coding gene Chr2:178125184-178131163 (+)
CBA/J MGP_CBAJ_G0026649
protein coding gene Chr2:191477213-191483416 (+)
DBA/2J MGP_DBA2J_G0026787
protein coding gene Chr2:170958817-170965042 (+)
FVB/NJ MGP_FVBNJ_G0026753
protein coding gene Chr2:169576177-169583003 (+)
LP/J MGP_LPJ_G0026888
protein coding gene Chr2:179341781-179347975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026772
protein coding gene Chr2:194408269-194414524 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027434
protein coding gene Chr2:177060436-177067002 (+)
PWK/PhJ MGP_PWKPhJ_G0025867
protein coding gene Chr2:170752482-170758735 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025667
protein coding gene Chr2:176062419-176068518 (+)
WSB/EiJ MGP_WSBEiJ_G0026203
protein coding gene Chr2:178015624-178021830 (+)



Homology
more
  • Human Ortholog
    PCK1, phosphoenolpyruvate carboxykinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCK1, phosphoenolpyruvate carboxykinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCKDC, PEPCK1, PEPCKC, PEPCK-C
  • Links
    NCBI Gene ID: 5105
    neXtProt AC: NX_P35558
    UniProt: P35558

  • Chr Location
    20q13.31; chr20:57561081-57566461 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 5 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18534 NCBI Gene Model | MGI Sequence Detail 6182 C57BL/6J ±  kb
    transcript NM_011044 RefSeq | MGI Sequence Detail 2637 C57BL/6  
    polypeptide Q9Z2V4 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012416 phosphoenolpyruvate carboxykinase, cytosolic [GTP]
    • EC
    • InterPro Domains
      IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
      IPR035077 Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain
      IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
      IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
      IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
      IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 365
      Genomic 2
      cDNA 355
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13174, MGD-MRK-13175, MGI:2138871
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 28
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:15656 Freytag SO, et al., Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes. J Biol Chem. 1984 Oct 25;259(20):12831-7
    • Latest
      J:263803 Zhang Y, et al., Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018 May 18;293(20):7894-7904

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory