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Pck1
Gene Detail
 Symbol
Name
ID
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
MGI:97501
Synonyms Pck-1, PEPCK
Feature Type protein coding gene
Genetic Map
Chromosome 2
95.79 cM, cytoband C1-qter
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr2:173153048-173159273 bp, + strand
From VEGA annotation of GRCm38

  6226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphoenolpyruvate carboxykinase (GTP)
Gene Tree: Pck1

Human
homologs
Human Homolog PCK1, phosphoenolpyruvate carboxykinase 1 (soluble)
NCBI Gene ID 5105
neXtProt AC  NX_P35558
Human Synonyms  PEPCK1, PEPCKC, PEPCK-C
Human Chr (Location)  20q13.31; chr20:57561081-57566459 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PCK1
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process gluconeogenesis, glucose homeostasis, ...
Component cytoplasm, extracellular vesicular exosome
Function carboxylic acid binding, carboxy-lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (136)    Tissues (100)    Images (2)
Theiler Stages: 22, 24, 25, 26, 28
Assay TypeResults
RNA in situ 94
Northern blot 28
RT-PCR 14
cDNA source data(350)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(364) Genomic(2) cDNA(354) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016689 (Evidence)
Ensembl Gene ModelENSMUSG00000027513 (Evidence)
Entrez Gene18534 (Evidence)
UniGene266867
DFCITC1572221, TC1640568, TC1769315
DoTSDT.101713552, DT.87073206, DT.87073231
NIA Mouse Gene IndexU002912
EC4.1.1.32
Consensus CDS ProjectCCDS17141.1
International Mouse Knockout Project StatusPck1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016689 VEGA Gene Model | MGI Sequence Detail 6226 C57BL/6J ±  kb
transcript OTTMUST00000040420 VEGA | MGI Sequence Detail 2661 Not Applicable 
polypeptide OTTMUSP00000018058 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
InterPro IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
InterPro IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
InterPro IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
Protein Ontology PR:000012416 phosphoenolpyruvate carboxykinase, cytosolic [GTP]
References (Earliest) J:15656 Freytag SO, et al., Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes. J Biol Chem. 1984 Oct 25;259(20):12831-7
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(105)
Other
accession IDs
MGD-MRK-13174, MGD-MRK-13175, MGI:2138871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory