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Pck1
Gene Detail
Symbol

Name
ID
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
MGI:97501
Synonyms
Pck-1, PEPCK
Feature Type
protein coding gene
Genetic Map
Chromosome 2
95.79 cM, cytoband C1-qter
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr2:173153048-173159273 bp, + strand
From VEGA annotation of GRCm38

  6226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PCK1
Protein SuperFamily: phosphoenolpyruvate carboxykinase (GTP)
Gene Tree: Pck1

Human
homologs
PCK1, phosphoenolpyruvate carboxykinase 1 (soluble)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5105
neXtProt AC: NX_P35558

Human Synonyms: PEPCK1, PEPCKC, PEPCK-C

Human Chr (Location): 20q13.31; chr20:57561081-57566461 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PCK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry.
 
Interactions
Pck1 interacts with 135 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to potassium ion starvation, gluconeogenesis, ...
Component cytoplasm, cytosol, ...
Function carboxylic acid binding, carboxy-lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (136)    Tissues (101)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 28
RT-PCR 14
cDNA source data(350)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pck1 ; ZFIN pck1    NEW 
Molecular
reagents
All nucleic(364) Genomic(2) cDNA(354) Primer pair(5) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016689 (Evidence)
Ensembl Gene Model ENSMUSG00000027513 (Evidence)
Entrez Gene 18534 (Evidence)
UniGene 266867
DFCI TC1572221, TC1640568, TC1769315
DoTS DT.101713552, DT.87073206, DT.87073231
NIA Mouse Gene Index U002912
EC 4.1.1.32
Consensus CDS Project CCDS17141.1
International Mouse Phenotyping Consortium Status Pck1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016689 VEGA Gene Model | MGI Sequence Detail 6226 C57BL/6J ±  kb
transcript OTTMUST00000040420 VEGA | MGI Sequence Detail 2661 Not Applicable 
polypeptide OTTMUSP00000018058 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
InterPro IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
InterPro IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
InterPro IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
Protein Ontology PR:000012416 phosphoenolpyruvate carboxykinase, cytosolic [GTP]
References
(Earliest) J:15656 Freytag SO, et al., Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes. J Biol Chem. 1984 Oct 25;259(20):12831-7
(Latest) J:218247 Cossette SM, et al., Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open. 2014;4(1):48-61
All references(105)
Other
accession IDs
MGD-MRK-13174, MGD-MRK-13175, MGI:2138871

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory