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Pck1 Gene Detail
Summary
  • Symbol
    Pck1
  • Name
    phosphoenolpyruvate carboxykinase 1, cytosolic
  • Synonyms
    Pck-1, PEPCK
  • Feature Type
    protein coding gene
  • IDs
    MGI:97501
    NCBI Gene: 18534
  • Gene Overview
    MyGene.info: PCK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:173153048-173159273 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6226 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 95.79 cM, cytoband C1-qter
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    PCK1, phosphoenolpyruvate carboxykinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCK1, phosphoenolpyruvate carboxykinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCKDC, PEPCK1, PEPCKC, PEPCK-C
  • Links
    NCBI Gene ID: 5105
    neXtProt AC: NX_P35558
    UniProt: P35558

  • Chr Location
    20q13.31; chr20:57561081-57566461 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 5 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early postnatal lethality, decreased body fat, decreased glycogen levels in the liver, and altered blood chemistry.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016689 VEGA Gene Model | MGI Sequence Detail 6226 C57BL/6J ±  kb
    transcript OTTMUST00000040420 VEGA | MGI Sequence Detail 2661 Not Applicable  
    polypeptide OTTMUSP00000018058 VEGA | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      47 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012416 phosphoenolpyruvate carboxykinase, cytosolic [GTP]
    • EC
    • InterPro Domains
      IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal
      IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising
      IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
      IPR035077 Phosphoenolpyruvate carboxykinase, GTP-utilising, C-terminal
      IPR035078 Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal
      IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 364
      Genomic 2
      cDNA 354
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13174, MGD-MRK-13175, MGI:2138871
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 28
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:15656 Freytag SO, et al., Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes. J Biol Chem. 1984 Oct 25;259(20):12831-7
    • Latest
      J:241361 Sharabi K, et al., Selective Chemical Inhibition of PGC-1alpha Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 Mar 23;169(1):148-160.e15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory