Sequence Detail

ID/Version

Q9Z2V4 Q3UEH3 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Phosphoenolpyruvate carboxykinase, cytosolic [GTP] {ECO:0000305}; Short=PEPCK-C; EC=4.1.1.32 {ECO:0000269|PubMed:11792850, ECO:0000269|PubMed:29230018, ECO:0000269|PubMed:30193097};AltName: Full=Serine-protein kinase PCK1 {EC

Provider

SWISS-PROT

Sequence

Polypeptide 622 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	86	111	3	12

Sequence references in MGI

J:53427 Williams CP, et al., Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Mol Cell Endocrinol. 1999 Feb 25;148(1-2):67-77
J:63929 She P, et al., Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep;20(17):6508-17
J:73977 Olswang Y, et al., A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):625-30
J:76767 Allen-Jennings AE, et al., The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. J Biol Chem. 2002 May 31;277(22):20020-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102459 Cassuto H, et al., Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. J Biol Chem. 2005 Oct 7;280(40):33873-84
J:257496 Ma R, et al., A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8(+) T cells. Nat Cell Biol. 2018 Jan;20(1):21-27
J:265944 Latorre-Muro P, et al., Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Mol Cell. 2018 Sep 6;71(5):718-732.e9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89