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Pbx1
Gene Detail
Symbol

Name
ID
Pbx1
pre B cell leukemia homeobox 1
MGI:97495
Synonyms
2310056B04Rik, D230003C07Rik, Pbx-1, Pbx1a, Pbx1b
Feature Type
protein coding gene
Genetic Map
Chromosome 1
75.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:168119364-168432270 bp, - strand
From VEGA annotation of GRCm38

  312907 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PBX1
Gene Tree: Pbx1

Human
homologs
PBX1, pre-B-cell leukemia homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5087
neXtProt AC: NX_P40424

Human Chr (Location): 1q23; chr1:164559360-164886047 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(17) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene causes late gestational death, hypoplasia/aplasia of many organs, impaired hematopoiesis, anemia, skin edema, axial and appendicular skeleton defects, absent adrenal glands, abnormal chondrocyte differentiation, and abnormal bone, kidney and pancreas development.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Pbx1 interacts with 468 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process adrenal gland development, anterior/posterior pattern specification, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (222)    Tissues (182)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 73
RNA in situ 129
Western blot 10
RT-PCR 10
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PBX1 ; Xenbase pbx1 ; ZFIN pbx1a    NEW 
Molecular
reagents
All nucleic(27) cDNA(23) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000040100 (Evidence)
Ensembl Gene Model ENSMUSG00000052534 (Evidence)
Entrez Gene 18514 (Evidence)
DFCI TC1582853, TC1585424, TC1587497, TC1591645, TC1619405, TC1621090, TC1696284
DoTS DT.101154791, DT.101372066, DT.101735801, DT.110896774, DT.527356, DT.91322567, DT.91336657, DT.99840396
NIA Mouse Gene Index U022020
PDB 1LFU, 1DU6
Consensus CDS Project CCDS15461.1, CCDS15462.1
International Mouse Phenotyping Consortium Status Pbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040100 VEGA Gene Model | MGI Sequence Detail 312907 C57BL/6J ±  kb
transcript OTTMUST00000104168 VEGA | MGI Sequence Detail 6876 Not Applicable 
polypeptide OTTMUSP00000058266 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(12) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(3970 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR005542 PBX
Protein Ontology PR:000012326 pre-B-cell leukemia transcription factor 1
References
(Earliest) J:13147 Kamps MP, et al., A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990 Feb 23;60(4):547-55
(Latest) J:217429 Cho OH, et al., Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development. Dev Dyn. 2015 Jan;244(1):43-55
All references(137)
Other
accession IDs
MGD-MRK-13163, MGD-MRK-13164, MGI:1917652, MGI:2138350, MGI:2138411, MGI:2444643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory