Pbx1
Gene Detail

Symbol Name ID

Pbx1 pre B cell leukemia homeobox 1 MGI:97495

Synonyms

2310056B04Rik, D230003C07Rik, Pbx-1, Pbx1a, Pbx1b

Feature Type

protein coding gene

Genetic Map

Chromosome 1

75.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:168153527-168432270 bp, - strand From VEGA annotation of GRCm38   278744 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Pbx1

Human homologs

Human Homolog		PBX1, pre-B-cell leukemia homeobox 1
NCBI Gene ID		5087
neXtProt AC		NX_P40424
Human Chr (Location)		1q23; chr1:164528597-164821067 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(29) : Targeted(10) Gene trapped(19)
 

Homozygous disruption of this gene causes late gestational death, hypoplasia/aplasia of many organs, impaired hematopoiesis, anemia, skin edema, axial and appendicular skeleton defects, absent adrenal glands, abnormal chondrocyte differentiation, and abnormal bone, kidney and pancreas development.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	adrenal gland development, anterior/posterior pattern specification, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (52 records)
Data Summary: Results (202)    Tissues (170)    Images (50)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	57
RNA in situ	129
Western blot	10
RT-PCR	6

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(23) Primer pair(2) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000040100 (Evidence)
Ensembl Gene Model	ENSMUSG00000052534 (Evidence)
Entrez Gene	18514 (Evidence)
DFCI	TC1582853, TC1585424, TC1587497, TC1591645, TC1619405, TC1621090, TC1696284
DoTS	DT.101154791, DT.101372066, DT.101735801, DT.110896774, DT.527356, DT.91322567, DT.91336657, DT.99840396
NIA Mouse Gene Index	U022020
PDB	1LFU, 1DU6
Consensus CDS Project	CCDS15461.1, CCDS15462.1
International Mouse Knockout Project Status	Pbx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040100	VEGA Gene Model | MGI Sequence Detail	278744	C57BL/6J
transcript	OTTMUST00000104168	VEGA | MGI Sequence Detail	6891	Not Applicable
polypeptide	OTTMUSP00000058266	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(85) RefSeq(4) UniProt(8)

Polymorphisms

RFLP(2) : SNPs(2704 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR005542	PBX
Protein Ontology	PR:000012326	pre-B-cell leukemia transcription factor 1

References

(Earliest) J:13147 Kamps MP, et al., A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990 Feb 23;60(4):547-55
(Latest) J:185964 Sgado P, et al., The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24
All references(128)

Other accession IDs

MGD-MRK-13163, MGD-MRK-13164, MGI:1917652, MGI:2138350, MGI:2138411, MGI:2444643