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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pbx1
pre B cell leukemia homeobox 1
MGI:97495
31 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cdkn2btm1Bbd/\Cdkn2btm1Bbd
\Pbx1tm1Koss/\Pbx1tm1Koss
\Nkx2-5tm2(cre)Rph/\Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv 		abnormal spleen mesenchyme morphology J:184521
abnormal spleen morphology J:184521
\Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/\Gt(ROSA)26Sor+
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2+
\Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ 		normal craniofacial phenotype J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2+
\Foxg1tm1(cre)Skm/\Foxg1+
involves: 129P2/OlaHsd * 129S/Sv 		abnormal maxillary shelf morphology J:178316
abnormal nasal capsule morphology J:178316
absent premaxilla J:178316
bilateral cleft upper lip J:178316
cleft palate J:178316
neonatal lethality, complete penetrance J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2+
\H2az2Tg(Wnt1-cre)11Rth/\H2az2+
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J 		cleft palate J:178316
normal nervous system phenotype J:178316
postnatal lethality, complete penetrance J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2+
\Nkx2-5tm2(cre)Rph/\Nkx2-5+
involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv 		abnormal spleen morphology J:184521
spleen hypoplasia J:184521
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2+
\Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd * 129S/Sv 		cleft palate J:178316
cleft upper lip J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx2tm1Mlc/\Pbx2tm1Mlc
\Foxg1tm1(cre)Skm/\Foxg1+
involves: 129P2/OlaHsd * 129S/Sv 		bilateral cleft upper lip J:178316
decreased apoptosis J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx3tm1Mlc/\Pbx3+
\Foxg1tm1(cre)Skm/\Foxg1+
involves: 129P2/OlaHsd 		cleft palate J:178316
cleft upper lip J:178316
\Pbx1tm1Koss/\Pbx1tm1Koss
\Pbx3tm1Mlc/\Pbx3+
\Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd 		cleft palate J:178316
cleft upper lip J:178316
\Pbx1tm1Mlc/\Pbx1+
\Pbx2tm1Mlc/\Pbx2+
\Pbx3tm1Mlc/\Pbx3+
involves: 129S6/SvEvTac 		cleft palate J:178316
neonatal lethality, complete penetrance J:178316
\Pbx1tm1Mlc/\Pbx1+
\Wnt9btm1Amc/\Wnt9btm1Amc
\Foxg1tm1(cre)Skm/\Foxg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ 		bilateral cleft upper lip J:178316
cleft palate J:178316
\Pbx1tm1Mlc/\Pbx1tm1Mlc
\Pbx2tm1Mlc/\Pbx2+
involves: 129S6/SvEvTac 		abnormal lateral nasal prominence morphology J:178316
abnormal maxillary prominence morphology J:178316
abnormal medial nasal prominence morphology J:178316
bilateral cleft upper lip J:178316
cleft upper lip J:178316
edema J:178316
micrognathia J:178316
small snout J:178316
tongue hypoplasia J:178316
unilateral cleft upper lip J:178316
\Pbx1tm1Mlc/\Pbx1tm1Mlc
\Pbx3tm1Mlc/\Pbx3+
involves: 129S6/SvEvTac 		bilateral cleft palate J:178316
bilateral cleft upper lip J:178316
cleft palate J:178316
edema J:178316
micrognathia J:178316
small snout J:178316
tongue hypoplasia J:178316
unilateral cleft palate J:178316
unilateral cleft upper lip J:178316
\Pdx1tm1Cvw/\Pdx1+
\Pbx1tm1Mlc/\Pbx1+
involves: 129S6/SvEvTac * C57BL/6 		decreased insulin secretion J:75811
disorganized pancreatic islets J:75811
hyperglycemia J:75811
impaired glucose tolerance J:75811
increased insulin sensitivity J:75811
increased urine glucose level J:75811
weight loss J:75811
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory