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Cdkn2btm1Bbd
Targeted Allele Detail
Summary
Symbol: Cdkn2btm1Bbd
Name: cyclin dependent kinase inhibitor 2B; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1933760
Synonyms: p15INK4b-
Gene: Cdkn2b  Location: Chr4:89224536-89229276 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2btm1Bbd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63299
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, encoding amino acids 44-130, was replaced by a neomycin cassette. No protein was detectable in Western blots of immunoprecipitates of MEF lysates derived from homozygous mutant embryos. (J:63299)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cdkn2btm1Bbd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2b Mutation:  6 strains or lines available
References
Original:  J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
02/27/2024
MGI 6.23
The Jackson Laboratory