Pax7
Gene Detail

Symbol Name ID

Pax7 paired box gene 7 MGI:97491

Synonyms

Pax-7

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr4:139737062-139833530 bp, - strand From VEGA annotation of GRCm38   96469 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: paired box protein PAX
Gene Tree: Pax7

Human homologs

Human Homolog		PAX7, paired box 7
NCBI Gene ID		5081
neXtProt AC		NX_P23759
Human Synonyms		HUP1, PAX7B, RMS2
Human Chr (Location)		1p36.13; chr1:18957500-19075360 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PAX7

Alleles and phenotypes

All alleles(17) : Targeted(15) Gene trapped(2)
 

Mice homozygous for a targeted null mutation exhibit craniofacial malformations involving the nose and maxilla, and die within three weeks after birth.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cartilage development, chromatin remodeling, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (211 records)
Data Summary: Results (512)    Tissues (246)    Images (98)
Theiler Stages: 2, 3, 13, 15, 16, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	409
In situ reporter (knock in)	2
Northern blot	19
RT-PCR	58

cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(2) cDNA(26) Primer pair(9) Other(7)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010060 (Evidence)
Ensembl Gene Model	ENSMUSG00000028736 (Evidence)
Entrez Gene	18509 (Evidence)
UniGene	218760
DFCI	TC1598667
DoTS	DT.483226, DT.87055483
NIA Mouse Gene Index	U025705
Consensus CDS Project	CCDS18850.1
International Mouse Knockout Project Status	Pax7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010060	VEGA Gene Model | MGI Sequence Detail	96469	C57BL/6J
transcript	OTTMUST00000097164	VEGA | MGI Sequence Detail	1725	Not Applicable
polypeptide	OTTMUSP00000054430	VEGA | MGI Sequence Detail	505	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(15) : SNPs(446 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR022106	Paired box protein 7
InterPro	IPR001523	Paired domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000012319	paired box protein Pax-7

References

(Earliest) J:11250 Jostes B, et al., The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990 Dec;33(1):27-37
(Latest) J:194471 Borensztein M, et al., Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse. Development. 2013 Mar;140(6):1231-9
All references(297)

Other accession IDs

MGD-MRK-13150, MGD-MRK-13159