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Pax7 Gene Detail
Summary
  • Symbol
    Pax7
  • Name
    paired box 7
  • Synonyms
    Pax-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:97491
    NCBI Gene: 18509
  • Gene Overview
    MyGene.info: PAX7
Location & Maps
more
  • Sequence Map
    Chr4:139737062-139833528 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96467 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.83 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PAX7, paired box 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PAX7, paired box 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HUP1, PAX7B, RMS2
  • Links
    NCBI Gene ID: 5081
    neXtProt AC: NX_P23759

  • Chr Location
    1p36.13; chr1:18631006-18748866 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PAX7 associations

Human Disease Mouse Models
       Rhabdomyosarcoma 2; RMS2   OMIM: 268220
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 10 alleles in 14 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    20
  • Genomic Mutations
    3 involving Pax7
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit craniofacial malformations involving the nose and maxilla, and die within three weeks after birth. Mice homozygous for floxed alleles activated in muscle cells exhibit reduced satellite cell numbers and impaired muscle regeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010060 VEGA Gene Model | MGI Sequence Detail 96467 C57BL/6J ±  kb
transcript OTTMUST00000097164 VEGA | MGI Sequence Detail 1725 Not Applicable  
polypeptide OTTMUSP00000054430 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    956 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 43
    Genomic 2
    cDNA 24
    Primer pair 9
    Other 8

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-13150, MGD-MRK-13159
References
more
  • Summaries
    All 394
    Developmental Gene Expression 261
    Gene Ontology 14
    Phenotypes 106
  • Earliest
    J:11250 Jostes B, et al., The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990 Dec;33(1):27-37
  • Latest
    J:233763 Karpinski BA, et al., A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol. 2016 Jul 15;415(2):228-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory