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Pax7 Gene Detail
Summary
  • Symbol
    Pax7
  • Name
    paired box 7
  • Synonyms
    Pax-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:97491
    NCBI Gene: 18509
  • Gene Overview
    MyGene.info: PAX7
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139737059-139833026 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.83 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    953 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97491
protein coding gene Chr4:139737059-139833528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029023
protein coding gene Chr4:142589097-142697083 (-)
A/J MGP_AJ_G0028982
protein coding gene Chr4:136460751-136560161 (-)
AKR/J MGP_AKRJ_G0028934
protein coding gene Chr4:140374569-140486791 (-)
BALB/cJ MGP_BALBcJ_G0029006
protein coding gene Chr4:137141342-137249182 (-)
C3H/HeJ MGP_C3HHeJ_G0028720
protein coding gene Chr4:140763051-140880677 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029447
protein coding gene Chr4:147646669-147761342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026718
protein coding gene Chr4:129414171-129514578 (-)
CAST/EiJ MGP_CASTEiJ_G0028152
protein coding gene Chr4:138937620-139079585 (-)
CBA/J MGP_CBAJ_G0028684
protein coding gene Chr4:151881697-151981338 (-)
DBA/2J MGP_DBA2J_G0028834
protein coding gene Chr4:136862720-136966668 (-)
FVB/NJ MGP_FVBNJ_G0028801
protein coding gene Chr4:135900725-136011686 (-)
LP/J MGP_LPJ_G0028933
protein coding gene Chr4:142673835-142770636 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028827
protein coding gene Chr4:155784812-155892711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029485
protein coding gene Chr4:140901897-141006853 (-)
PWK/PhJ MGP_PWKPhJ_G0027873
protein coding gene Chr4:133712153-133816693 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027698
protein coding gene Chr4:136692138-136793892 (-)
WSB/EiJ MGP_WSBEiJ_G0028230
protein coding gene Chr4:141173858-141280649 (-)



Homology
more
  • Human Ortholog
    PAX7, paired box 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PAX7, paired box 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUP1, PAX7B, RMS2
  • Links
    NCBI Gene ID: 5081
    neXtProt AC: NX_P23759
    UniProt: P23759

  • Chr Location
    1p36.13; chr1:18631006-18748866 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PAX7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 10 alleles in 14 genetic backgrounds
    38 phenotypes from multigenic genotypes
    4 images
    164 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit craniofacial malformations involving the nose and maxilla, and die within three weeks after birth. Mice homozygous for floxed alleles activated in muscle cells exhibit reduced satellite cell numbers and impaired muscle regeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18509 NCBI Gene Model | MGI Sequence Detail 95968 C57BL/6J ±  kb
    transcript NM_011039 RefSeq | MGI Sequence Detail 4275 Not Specified  
    polypeptide P47239 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 2
      cDNA 24
      Primer pair 10
      Other 9

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-13150, MGD-MRK-13159
    References
    more
    • Summaries
      All 503
      Developmental Gene Expression 304
      Gene Ontology 14
      Phenotypes 164
    • Earliest
      J:11250 Jostes B, et al., The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990 Dec;33(1):27-37
    • Latest
      J:268274 Vogler TO, et al., TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018 Nov;563(7732):508-513

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    01/08/2019
    MGI 6.13
    The Jackson Laboratory