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Pax7
Gene Detail
Symbol

Name
ID
Pax7
paired box 7
MGI:97491
Synonyms
Pax-7
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:139737062-139833528 bp, - strand
From VEGA annotation of GRCm38

  96467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: paired box protein PAX
Gene Tree: Pax7

Human
homologs
Human Homolog PAX7, paired box 7
NCBI Gene ID 5081
neXtProt AC  NX_P23759
Human Synonyms  HUP1, PAX7B, RMS2
Human Chr (Location)  1p36.13; chr1:18631006-18748866 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PAX7
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(2) Targeted(19)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit craniofacial malformations involving the nose and maxilla, and die within three weeks after birth. Mice homozygous for floxed alleles activated in muscle cells exhibit reduced satellite cell numbers and impaired muscle regeneration.
 
Phenotype Images(4)
Interactions
Pax7 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cartilage development, chromatin remodeling, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (228 records)
Data Summary: Results (548)    Tissues (251)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 54
RNA in situ 415
In situ reporter (knock in) 2
Northern blot 19
RT-PCR 58
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(24) Primer pair(9) Other(8)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010060 (Evidence)
Ensembl Gene ModelENSMUSG00000028736 (Evidence)
Entrez Gene18509 (Evidence)
UniGene218760
DFCITC1598667
DoTSDT.483226, DT.87055483
NIA Mouse Gene IndexU025705
Consensus CDS ProjectCCDS18850.1
International Mouse Knockout Project StatusPax7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010060 VEGA Gene Model | MGI Sequence Detail 96467 C57BL/6J ±  kb
transcript OTTMUST00000097164 VEGA | MGI Sequence Detail 1725 Not Applicable 
polypeptide OTTMUSP00000054430 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(15) : SNPs within 2kb(963 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR022106 Paired box protein 7
InterPro IPR001523 Paired domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012319 paired box protein Pax-7
References
(Earliest) J:11250 Jostes B, et al., The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990 Dec;33(1):27-37
(Latest) J:213273 Rodgers JT, et al., mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19;510(7505):393-6
All references(335)
Other
accession IDs
MGD-MRK-13150, MGD-MRK-13159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory