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Pax5
Gene Detail
Symbol

Name
ID
Pax5
paired box 5
MGI:97489
Synonyms
EBB-1, Pax-5
Feature Type
protein coding gene
Genetic Map
Chromosome 4
23.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:44531145-44710487 bp, - strand
From VEGA annotation of GRCm38

  179343 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56419  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: paired box protein PAX
Gene Tree: Pax5

Human
homologs
Human Homolog PAX5, paired box 5
NCBI Gene ID 5079
neXtProt AC  NX_Q02548
Human Synonyms  ALL3, BSAP
Human Chr (Location)  9p13; chr9:36833275-37034479 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PAX5
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutants exhibit impaired development of the midbrain resulting in a reduced inferior colliculus and an altered cerebellar folial pattern, failure of B cell differentiation, runting, and high postnatal mortality with few survivors.
 
Interactions
Pax5 interacts with 117 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (243)    Tissues (113)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 167
In situ reporter (knock in) 9
Western blot 2
RT-PCR 51
RNase protection 12
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(25) Primer pair(8) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006705 (Evidence)
Ensembl Gene ModelENSMUSG00000014030 (Evidence)
Entrez Gene18507 (Evidence)
UniGene439659
DFCITC1639065
DoTSDT.40185518, DT.91592527
NIA Mouse Gene IndexU025012, U175833
Consensus CDS ProjectCCDS18125.1
International Mouse Knockout Project StatusPax5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006705 VEGA Gene Model | MGI Sequence Detail 179343 C57BL/6J ±  kb
transcript OTTMUST00000015403 VEGA | MGI Sequence Detail 1616 Not Applicable 
polypeptide OTTMUSP00000007106 VEGA | MGI Sequence Detail 391 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(6) UniProt(32)
Polymorphisms
RFLP(3) : SNPs within 2kb(1279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR022130 Paired-box protein 2 C-terminal
InterPro IPR001523 Paired domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000001903 paired box protein PAX-5
References
(Earliest) J:26648 Barberis A, et al., A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 1990 May;4(5):849-59
(Latest) J:212324 Lane AA, et al., Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet. 2014 Jun;46(6):618-23
All references(143)
Other
accession IDs
MGD-MRK-13148, MGD-MRK-13157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory