Otx2
Gene Detail

Symbol Name ID

Otx2 orthodenticle homolog 2 (Drosophila) MGI:97451

Synonyms

E130306E05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 14

25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr14:48657679-48667644 bp, - strand From VEGA annotation of GRCm38   9966 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Otx2

Human homologs

Human Homolog		OTX2, orthodenticle homeobox 2
NCBI Gene ID		5015
neXtProt AC		NX_P32243
Human Synonyms		CPHD6, MCOPS5
Human Chr (Location)		14q22.3; chr14:57267425-57277194 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human OTX2

Alleles and phenotypes

All alleles(47) : Targeted(33) Gene trapped(14)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis due to abnormal gastrulation and embryonic patterning in the brain and heart.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	anatomical structure development, anterior/posterior pattern specification, ...
Component	cytoplasm, growth cone, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (390 records)
Data Summary: Results (1268)    Tissues (398)    Images (425)
Theiler Stages: 2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	55
RNA in situ	1037
In situ reporter (knock in)	63
Northern blot	1
Western blot	9
RT-PCR	100
RNase protection	3

cDNA source data(50)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(102) Genomic(12) cDNA(57) Primer pair(13) Other(20)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000032534 (Evidence)
Ensembl Gene Model	ENSMUSG00000021848 (Evidence)
Entrez Gene	18424 (Evidence)
UniGene	134516
DFCI	TC1582397, TC1589462, TC1774779
DoTS	DT.101714282, DT.91335955, DT.97412485, DT.97412487
NIA Mouse Gene Index	U035481
PDB	2DMS
Consensus CDS Project	CCDS49473.1
International Mouse Knockout Project Status	Otx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032534	VEGA Gene Model | MGI Sequence Detail	9966	C57BL/6J
transcript	OTTMUST00000080958	VEGA | MGI Sequence Detail	1708	Not Applicable
polypeptide	OTTMUSP00000043186	VEGA | MGI Sequence Detail	297	Not Applicable

All sequences(66) RefSeq(2) UniProt(8)

Polymorphisms

PCR(1) : SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003025	Transcription factor Otx
InterPro	IPR003022	Transcription factor Otx2
InterPro	IPR013851	Transcription factor Otx, C-terminal
Protein Ontology	PR:000012086	homeobox protein OTX2

References

(Earliest) J:2076 Simeone A, et al., Nested expression domains of four homeobox genes in developing rostral brain [see comments]. Nature. 1992 Aug 20;358(6388):687-90
(Latest) J:194842 Yang J, et al., Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
All references(472)

Other accession IDs

MGD-MRK-13087, MGI:2444724