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Otx2
Gene Detail
 Symbol
Name
ID
Otx2
orthodenticle homolog 2
MGI:97451
Synonyms E130306E05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:48657679-48667644 bp, - strand
From VEGA annotation of GRCm38

  9966 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11026  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Otx2

Human
homologs
Human Homolog OTX2, orthodenticle homeobox 2
NCBI Gene ID 5015
neXtProt AC  NX_P32243
Human Synonyms  CPHD6, MCOPS5
Human Chr (Location)  14q22.3; chr14:56800707-56810476 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human OTX2
Alleles
and
phenotypes
All alleles(47) : Targeted(33) Gene trapped(14)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis due to abnormal gastrulation and embryonic patterning in the brain and heart.
 
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process anatomical structure development, anterior/posterior pattern specification, ...
Component cytoplasm, growth cone, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (407 records)
Data Summary: Results (1374)    Tissues (410)    Images (468)
Theiler Stages: 2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 55
RNA in situ 1120
In situ reporter (knock in) 81
Northern blot 1
Western blot 9
RT-PCR 105
RNase protection 3
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(81) Genomic(12) cDNA(33) Primer pair(13) Other(23)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000032534 (Evidence)
Ensembl Gene ModelENSMUSG00000021848 (Evidence)
Entrez Gene18424 (Evidence)
DFCITC1582397, TC1589462, TC1602685, TC1774779
DoTSDT.101714282, DT.91335955, DT.94162871, DT.97412485, DT.97412487
NIA Mouse Gene IndexU035481
PDB2DMS
Consensus CDS ProjectCCDS49473.1
International Mouse Knockout Project StatusOtx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032534 VEGA Gene Model | MGI Sequence Detail 9966 C57BL/6J ±  kb
transcript OTTMUST00000080958 VEGA | MGI Sequence Detail 1708 Not Applicable 
polypeptide OTTMUSP00000043186 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(20) UniProt(8)
Polymorphisms PCR(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003025 Transcription factor Otx
InterPro IPR003022 Transcription factor Otx2
InterPro IPR013851 Transcription factor Otx, C-terminal
Protein Ontology PR:000012086 homeobox protein OTX2
References (Earliest) J:2076 Simeone A, et al., Nested expression domains of four homeobox genes in developing rostral brain [see comments]. Nature. 1992 Aug 20;358(6388):687-90
(Latest) J:206591 Di Giovannantonio LG, et al., Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 2014 Jan;141(2):377-88
All references(493)
Other
accession IDs
MGD-MRK-13087, MGI:2444724

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory