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Symbol
Name
ID

Otx2
orthodenticle homeobox 2
MGI:97451

Phenotype annotations related to embryo

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

embryo phenotype

abnormal first pharyngeal arch morphology

absent pharyngeal arches

abnormal embryo development

abnormal developmental patterning

abnormal gastrulation

abnormal ectoderm development

abnormal mesendoderm development

abnormal mesoderm development

abnormal rostral-caudal axis patterning

rostral body truncation

embryonic growth arrest

embryonic growth retardation

decreased embryo size

abnormal embryonic tissue morphology

abnormal axial mesoderm morphology

absent prechordal mesoderm

abnormal neural tube morphology

abnormal embryonic neuroepithelium morphology

decreased embryonic neuroepithelium thickness

open neural tube

abnormal notochord morphology

abnormal primitive node morphology

abnormal primitive streak formation

abnormal somite development

abnormal somite shape

fused somites

impaired somite development

embryonic-extraembryonic boundary constriction

abnormal primitive streak elongation

abnormal allantois morphology

abnormal amnion morphology

abnormal visceral yolk sac morphology

abnormal visceral yolk sac endoderm morphology

abnormal visceral yolk sac mesenchyme morphology

Availability

Mouse Genotype

Otx2^tm1.2Tlam/Otx2^tm1.2Tlam

Otx2^tm1Pas/Otx2^tm1Pas

Otx2^tm1Sia/Otx2^tm1Sia

Otx2^tm1Sla/Otx2^tm1Sla

Otx2^tm2.1Imat/Otx2^tm2.1Imat

Otx2^tm2Asim/Otx2^tm2Asim

Otx2^tm7Sia/Otx2^tm7Sia

*

Otx2^tm9Sia/Otx2^tm9Sia

Otx2^tm10Asim/Otx2^tm10Asim

Otx2^tm10Sia/Otx2^tm10Sia

Otx2^tm1Pas/Otx2^tm2Asim

Otx2^tm1Sia/Otx2⁺

Otx2^tm1Sia/Otx2^tm4Sia

*

Otx2^tm1Sia/Otx2^tm9Sia

Otx2^tm1Sia/Otx2^tm10Sia

Otx2^tm1Sla/Otx2⁺

Otx2^tm2.1Imat/Otx2^tm7Sia

*

Otx2^tm9Asim/Otx2^tm10Asim

*

Otx2^tm10Asim/Otx2^tm11Asim

Otx2^tm7Sia/Otx2⁺
Tg(Lefty2-cre)21bHmd/? (conditional)

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23