Oprk1
Gene Detail

Symbol Name ID

Oprk1 opioid receptor, kappa 1 MGI:97439

Synonyms

KOR-1, Oprk2, R21

Feature Type

protein coding gene

Genetic Map

Chromosome 1

1.89 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr1:5588493-5606131 bp, + strand From VEGA annotation of GRCm38   17639 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20253  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprk1

Human homologs

Human Homolog		OPRK1, opioid receptor, kappa 1
NCBI Gene ID		4986
neXtProt AC		NX_P41145
Human Synonyms		KOR, OPRK
Human Chr (Location)		8q11.2; chr8:54138276-54164194 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit impaired response to morphine and an opioid agonist, abnormal pain threshold, and increased litter size.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	defense response to virus, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	dynorphin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(5) cDNA(14) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034734 (Evidence)
Ensembl Gene Model	ENSMUSG00000025905 (Evidence)
Entrez Gene	18387 (Evidence)
UniGene	7977
DFCI	TC1594066
DoTS	DT.40156497, DT.91327614
NIA Mouse Gene Index	U000012
Consensus CDS Project	CCDS14809.1
International Mouse Knockout Project Status	Oprk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034734	VEGA Gene Model | MGI Sequence Detail	17639	C57BL/6J
transcript	OTTMUST00000088257	VEGA | MGI Sequence Detail	2481	Not Applicable
polypeptide	OTTMUSP00000048085	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(40) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000452	Kappa opioid receptor
InterPro	IPR001418	Opioid receptor
Protein Ontology	PR:000001590	kappa-type opioid receptor

References

(Earliest) J:13204 Yasuda K, et al., Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(93)

Other accession IDs

MGD-MRK-13039, MGD-MRK-16304, MGI:99527