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Oprk1
Gene Detail
 Symbol
Name
ID
Oprk1
opioid receptor, kappa 1
MGI:97439
Synonyms KOR-1, Oprk2, R21
Feature Type protein coding gene
Genetic Map
Chromosome 1
1.89 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr1:5588493-5606131 bp, + strand
From VEGA annotation of GRCm38

  17639 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20253  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: opioid receptor
Gene Tree: Oprk1

Human
homologs
Human Homolog OPRK1, opioid receptor, kappa 1
NCBI Gene ID 4986
neXtProt AC  NX_P41145
Human Synonyms  KOR, K-OR-1, KOR-1, OPRK
Human Chr (Location)  8q11.2; chr8:53225716-53251697 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired response to morphine and an opioid agonist, abnormal pain threshold, and increased litter size.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process adenylate cyclase-inhibiting opioid receptor signaling pathway, behavior, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function dynorphin receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(5) cDNA(14) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034734 (Evidence)
Ensembl Gene ModelENSMUSG00000025905 (Evidence)
Entrez Gene18387 (Evidence)
UniGene7977
DFCITC1594066
DoTSDT.40156497, DT.91327614
NIA Mouse Gene IndexU000012
Consensus CDS ProjectCCDS14809.1
International Mouse Knockout Project StatusOprk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034734 VEGA Gene Model | MGI Sequence Detail 17639 C57BL/6J ±  kb
transcript OTTMUST00000088255 VEGA | MGI Sequence Detail 4675 Not Applicable 
polypeptide OTTMUSP00000048083 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000452 Kappa opioid receptor
InterPro IPR001418 Opioid receptor
Protein Ontology PR:000001590 kappa-type opioid receptor
References (Earliest) J:13204 Yasuda K, et al., Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40
(Latest) J:209658 Schmidt Y, et al., mu-Opioid receptor antibody reveals tissue-dependent specific staining and increased neuronal mu-receptor immunoreactivity at the injured nerve trunk in mice. PLoS One. 2013;8(11):e79099
All references(94)
Other
accession IDs
MGD-MRK-13039, MGD-MRK-16304, MGI:99527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory