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Oprk1 Gene Detail
Summary
  • Symbol
    Oprk1
  • Name
    opioid receptor, kappa 1
  • Synonyms
    KOR-1, Oprk2, R21
  • Feature Type
    protein coding gene
  • IDs
    MGI:97439
    NCBI Gene: 18387
  • Gene Overview
    MyGene.info: OPRK1
Location & Maps
more
  • Genetic Map
    Chromosome 1, 1.89 cM, cytoband A2-A3
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    OPRK1, opioid receptor kappa 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OPRK1, opioid receptor kappa 1
    Orthology source: HomoloGene
  • Synonyms
    KOR, K-OR-1, KOR-1, OPRK
  • Links
    NCBI Gene ID: 4986
    neXtProt AC: NX_P41145

  • Chr Location
    8q11.2; chr8:53225716-53251697 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 4 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired response to morphine and an opioid agonist, abnormal pain threshold, and increased litter size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034734 VEGA Gene Model | MGI Sequence Detail 17666 C57BL/6J ±  kb
transcript OTTMUST00000088255 VEGA | MGI Sequence Detail 4675 Not Applicable  
polypeptide OTTMUSP00000048083 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 20
    Genomic 5
    cDNA 14
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13039, MGD-MRK-16304, MGI:99527
References
more
  • Summaries
    All 96
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 35
  • Earliest
    J:13204 Yasuda K, et al., Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40
  • Latest
    J:232178 Gupta A, et al., Collybolide is a novel biased agonist of kappa-opioid receptors with potent antipruritic activity. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6041-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory