Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables G protein-coupled opioid receptor activity. Involved in locomotory behavior; regulation of saliva secretion; and sensory perception of pain. Acts upstream of or within G protein-coupled opioid receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; early conceptus; gut; limb mesenchyme; and uterus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; cocaine dependence; depressive disorder; and heroin dependence. Orthologous to human OPRK1 (opioid receptor kappa 1).