Symbol
Name
ID

Oprk1
opioid receptor, kappa 1
MGI:97439

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Addictive alcohol use
Disease(s) Associated with OPRK1	Addictive alcohol use
alcohol dependence

Mouse Phenotypes

behavior/neurological phenotype

enhanced behavioral response to cocaine

impaired behavioral response to morphine

impaired behavioral response to anesthetic

abnormal associative learning

abnormal avoidance learning behavior

decreased anxiety-related response

abnormal locomotor behavior

abnormal locomotor activation

abnormal pain threshold

abnormal chemically-elicited antinociception

decreased chemically-elicited antinociception

Availability

Mouse Genotype

Oprk1^tm1.2Waca/Oprk1^tm1.2Waca

Oprk1^tm1Jep/Oprk1^tm1Jep

Oprk1^tm1Kff/Oprk1^tm1Kff

Oprk1^tm1.1Waca/Oprk1^tm1.1Waca
Tg(Slc6a3-icre)9075Gsc/0 (conditional)

Oprk1^tm2.1Kff/Oprk1^tm2.1Kff
Slc6a3^tm1(cre)Xz/0 (conditional)

Oprk1^tm2.1Kff/Oprk1^tm2.1Kff
Tg(Fev-cre)1Esd/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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