Symbol
Name
ID

Oprk1
opioid receptor, kappa 1
MGI:97439

Phenotype annotations related to behavior/neurological

Darker colors indicate more annotations

Human Phenotypes	Addictive alcohol use
Disease(s) Associated with OPRK1	Addictive alcohol use
alcohol dependence

Mouse Phenotypes

enhanced behavioral response to cocaine

impaired behavioral response to morphine

impaired behavioral response to anesthetic

abnormal associative learning

abnormal avoidance learning behavior

decreased anxiety-related response

abnormal locomotor behavior

abnormal locomotor activation

abnormal pain threshold

abnormal chemically-elicited antinociception

decreased chemically-elicited antinociception

Availability

Mouse Genotype

Oprk1^tm1.2Waca/Oprk1^tm1.2Waca

Oprk1^tm1Jep/Oprk1^tm1Jep

Oprk1^tm1Kff/Oprk1^tm1Kff

Oprk1^tm1.1Waca/Oprk1^tm1.1Waca
Tg(Slc6a3-icre)9075Gsc/0 (conditional)

Oprk1^tm2.1Kff/Oprk1^tm2.1Kff
Slc6a3^tm1(cre)Xz/0 (conditional)

Oprk1^tm2.1Kff/Oprk1^tm2.1Kff
Tg(Fev-cre)1Esd/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24