Mog
Gene Detail

Symbol Name ID

Mog myelin oligodendrocyte glycoprotein MGI:97435

Synonyms

B230317G11Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.16 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr17:37010746-37023398 bp, - strand From VEGA annotation of GRCm38   12653 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:111009  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 13 chicken

Protein SuperFamily: myelin-oligodendrocyte glycoprotein
Gene Tree: Mog

Human homologs

Human Homolog		MOG, myelin oligodendrocyte glycoprotein
NCBI Gene ID		4340
neXtProt AC		NX_Q16653
Human Synonyms		MOGIG2, NRCLP7
Human Chr (Location)		6p22.1; chr6:29624758-29640149 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MOG

Alleles and phenotypes

All alleles(72) : Targeted(5) Gene trapped(67)
 

While one line of homozygous mutant mice showed resistance to experimental autoimmune encephalomyelitis (EAE), another showed increased susceptibility.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	cell adhesion, positive regulation of MyD88-dependent toll-like receptor signaling pathway
Component	integral to membrane, membrane

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (3)    Images (1)
Theiler Stages: 26, 28

Assay Type	Results
RT-PCR	10

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(20) cDNA(19) Primer pair(4) Other(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014932 (Evidence)
Ensembl Gene Model	ENSMUSG00000076439 (Evidence)
Entrez Gene	17441 (Evidence)
UniGene	210857
DFCI	TC1580292, TC1730504
DoTS	DT.55248242, DT.60104903
NIA Mouse Gene Index	U037780
PDB	1PY9
Consensus CDS Project	CCDS28734.1
International Mouse Knockout Project Status	Mog

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014932	VEGA Gene Model | MGI Sequence Detail	12653	C57BL/6J
transcript	OTTMUST00000035462	VEGA | MGI Sequence Detail	1701	Not Applicable
polypeptide	OTTMUSP00000015874	VEGA | MGI Sequence Detail	247	Not Applicable

All sequences(37) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR003596	Immunoglobulin V-set, subgroup
InterPro	IPR016663	Myelin-oligodendrocyte glycoprotein
Protein Ontology	PR:000010514	myelin-oligodendrocyte glycoprotein

References

(Earliest) J:849 Amiguet P, et al., Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J Neurochem. 1992 May;58(5):1676-82
(Latest) J:187788 Zhang X, et al., CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. Eur J Immunol. 2012 Apr;42(4):924-35
All references(70)

Other accession IDs

MGD-MRK-13032, MGI:2443229