About   Help   FAQ
Mog Gene Detail
Summary
  • Symbol
    Mog
  • Name
    myelin oligodendrocyte glycoprotein
  • Synonyms
    B230317G11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:97435
    NCBI Gene: 17441
Location & Maps
more
  • Sequence Map
    Chr17:37010743-37023398 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12656 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MOG, myelin oligodendrocyte glycoprotein
  • Vertebrate Orthologs
    21
  • Human Ortholog
    MOG, myelin oligodendrocyte glycoprotein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTN6, BTNL11, MOGIG2, NRCLP7
  • Links
    NCBI Gene ID: 4340
    neXtProt AC: NX_Q16653

  • Chr Location
    6p22.1; chr6:29656981-29672372 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MOG associations

Human Disease Mouse Models
       Narcolepsy 7; NRCLP7   OMIM: 614250
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    75
  • Gene trapped
    68
  • Targeted
    7
  • Genomic Mutations
    1 involving Mog
  • Incidental Mutations
While one line of homozygous mutant mice showed resistance to experimental autoimmune encephalomyelitis (EAE), another showed increased susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014932 VEGA Gene Model | MGI Sequence Detail 12656 C57BL/6J ±  kb
transcript OTTMUST00000035462 VEGA | MGI Sequence Detail 1704 Not Applicable  
polypeptide OTTMUSP00000015874 VEGA | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Polymorphisms
less
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010514 myelin-oligodendrocyte glycoprotein
  • PDB
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
    IPR016663 Myelin-oligodendrocyte glycoprotein
Molecular
Reagents
less
  • All nucleic 46
    Genomic 20
    cDNA 19
    Primer pair 4
    Other 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13032, MGI:2443229
References
more
  • Summaries
    All 73
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:849 Amiguet P, et al., Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J Neurochem. 1992 May;58(5):1676-82
  • Latest
    J:221642 Klingler E, et al., The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Development. 2015 Jun 1;142(11):2026-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory