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Nodal
Gene Detail
Symbol

Name
ID
Nodal
nodal
MGI:97359
STS
Synonyms
Tg.413d
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:61417972-61425338 bp, + strand
From VEGA annotation of GRCm38

  7367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NODAL
Protein SuperFamily: Nodal protein
Gene Tree: Nodal

Human
homologs
NODAL, nodal growth differentiation factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4838
neXtProt AC: NX_Q96S42

Human Synonyms: HTX5

Human Chr (Location): 10q22.1; chr10:70431936-70441709 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NODAL

Mutations,
alleles, and
phenotypes
All mutations/alleles(83) : Gene trapped(63) Targeted(19) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects.
 
Interactions
Nodal interacts with 148 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (212 records)
Data Summary: Results (396)    Tissues (73)    Images (151)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 282
In situ reporter (knock in) 56
RT-PCR 58
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100497218 ; ZFIN ndr1, ndr2    NEW 
Molecular
reagents
All nucleic(40) Genomic(3) cDNA(11) Primer pair(11) Other(15)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021483 (Evidence)
Ensembl Gene Model ENSMUSG00000037171 (Evidence)
Entrez Gene 18119 (Evidence)
DFCI TC1590164
DoTS DT.87039260
NIA Mouse Gene Index U011564
Consensus CDS Project CCDS23878.1
International Mouse Phenotyping Consortium Status Nodal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021483 VEGA Gene Model | MGI Sequence Detail 7367 C57BL/6J ±  kb
transcript OTTMUST00000050919 VEGA | MGI Sequence Detail 2095 Not Applicable 
polypeptide OTTMUSP00000023886 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000105 nodal protein
References
(Earliest) J:11389 Conlon FL, et al., A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development. 1991 Apr;111(4):969-81
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(291)
Other
accession IDs
MGD-MRK-12907, MGD-MRK-15051, MGI:98714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory