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Nodal
Gene Detail
 Symbol
Name
ID
Nodal
nodal
MGI:97359
STS D10Mit112
Synonyms Tg.413d
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:61417972-61425338 bp, + strand
From VEGA annotation of GRCm38

  7367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Nodal protein
Gene Tree: Nodal

Human
homologs
Human Homolog NODAL, nodal growth differentiation factor
NCBI Gene ID 4838
neXtProt AC  NX_Q96S42
Human Synonyms  HTX5
Human Chr (Location)  10q22.1; chr10:70431936-70441709 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NODAL
Alleles
and
phenotypes
All alleles(83) : Gene trapped(63) Targeted(19) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, ...
Component extracellular region, extracellular space
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (199 records)
Data Summary: Results (369)    Tissues (73)    Images (136)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 259
In situ reporter (knock in) 52
RT-PCR 58
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) Genomic(3) cDNA(11) Primer pair(11) Other(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021483 (Evidence)
Ensembl Gene ModelENSMUSG00000037171 (Evidence)
Entrez Gene18119 (Evidence)
DFCITC1590164
DoTSDT.87039260
NIA Mouse Gene IndexU011564
Consensus CDS ProjectCCDS23878.1
International Mouse Knockout Project StatusNodal
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021483 VEGA Gene Model | MGI Sequence Detail 7367 C57BL/6J ±  kb
transcript OTTMUST00000050919 VEGA | MGI Sequence Detail 2095 Not Applicable 
polypeptide OTTMUSP00000023886 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000000105 nodal protein
References (Earliest) J:11389 Conlon FL, et al., A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development. 1991 Apr;111(4):969-81
(Latest) J:200709 Botilde Y, et al., Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Dev Biol. 2013 Sep 1;381(1):203-12
All references(276)
Other
accession IDs
MGD-MRK-12907, MGD-MRK-15051, MGI:98714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory