Nodal
Gene Detail

Symbol Name ID

Nodal nodal MGI:97359

STS

D10Mit112

Synonyms

Tg.413d

Feature Type

protein coding gene

Genetic Map

Chromosome 10

32.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:61417972-61425338 bp, + strand From VEGA annotation of GRCm38   7367 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8417  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Nodal protein
Gene Tree: Nodal

Human homologs

Human Homolog		NODAL, nodal growth differentiation factor
NCBI Gene ID		4838
neXtProt AC		NX_Q96S42
Human Synonyms		HTX5
Human Chr (Location)		10q22.1; chr10:72191692-72201465 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NODAL

Alleles and phenotypes

All alleles(83) : Targeted(19) Gene trapped(63) Transgenic(1)
 

Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (97 annotations)

Process	anatomical structure formation involved in morphogenesis, anterior/posterior axis specification, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (191 records)
Data Summary: Results (317)    Tissues (73)    Images (130)
Theiler Stages: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	207
In situ reporter (knock in)	52
RT-PCR	58

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(3) cDNA(11) Primer pair(11) Other(13)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021483 (Evidence)
Ensembl Gene Model	ENSMUSG00000037171 (Evidence)
Entrez Gene	18119 (Evidence)
DFCI	TC1590164
DoTS	DT.87039260
NIA Mouse Gene Index	U011564
Consensus CDS Project	CCDS23878.1
International Mouse Knockout Project Status	Nodal

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021483	VEGA Gene Model | MGI Sequence Detail	7367	C57BL/6J
transcript	OTTMUST00000050919	VEGA | MGI Sequence Detail	2095	Not Applicable
polypeptide	OTTMUSP00000023886	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000000105	nodal protein

References

(Earliest) J:11389 Conlon FL, et al., A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development. 1991 Apr;111(4):969-81
(Latest) J:191052 Wu Q, et al., Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development. 2013 Jan;140(2):291-300
All references(269)

Other accession IDs

MGD-MRK-12907, MGD-MRK-15051, MGI:98714