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Nkx2-6 Gene Detail
Summary
  • Symbol
    Nkx2-6
  • Name
    NK2 homeobox 6
  • Synonyms
    Nkx-2.6, Nkx2.6, tinman, Tix
  • Feature Type
    protein coding gene
  • IDs
    MGI:97351
    NCBI Gene: 18092
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:69409251-69412967 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.01 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97351
protein coding gene Chr14:69409251-69412989 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021514
protein coding gene Chr14:63938640-63942400 (+)
A/J MGP_AJ_G0021473
protein coding gene Chr14:62425426-62429142 (+)
AKR/J MGP_AKRJ_G0021449
protein coding gene Chr14:64522019-64525735 (+)
BALB/cJ MGP_BALBcJ_G0021479
protein coding gene Chr14:62404553-62408265 (+)
C3H/HeJ MGP_C3HHeJ_G0021256
protein coding gene Chr14:64248676-64252392 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021918
protein coding gene Chr14:66856209-66859913 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019458
protein coding gene Chr14:60266564-60270289 (+)
CAST/EiJ MGP_CASTEiJ_G0020773
protein coding gene Chr14:60780063-60783819 (+)
CBA/J MGP_CBAJ_G0021223
protein coding gene Chr14:68941681-68945393 (+)
DBA/2J MGP_DBA2J_G0021346
protein coding gene Chr14:62025809-62029529 (+)
FVB/NJ MGP_FVBNJ_G0021325
protein coding gene Chr14:61443303-61446999 (+)
LP/J MGP_LPJ_G0021421
protein coding gene Chr14:65007024-65010784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021354
protein coding gene Chr14:67897964-67901686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021941
protein coding gene Chr14:63776079-63779783 (+)
PWK/PhJ MGP_PWKPhJ_G0020517
protein coding gene Chr14:58775977-58779730 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020350
protein coding gene Chr14:59707307-59711117 (+)
WSB/EiJ MGP_WSBEiJ_G0020826
protein coding gene Chr14:64075257-64078959 (+)



Homology
more
  • Human Ortholog
    NKX2-6, NK2 homeobox 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX2-6, NK2 homeobox 6
  • Synonyms
    CSX2, CTHM, NKX2F, NKX4-2
  • Links
    NCBI Gene ID: 137814
    neXtProt AC: NX_A6NCS4
    UniProt: A6NCS4

  • Chr Location
    8p21.2; chr8:23702451-23706598 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NKX2-6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044186 Ensembl Gene Model | MGI Sequence Detail 3717 C57BL/6J ±  kb
transcript ENSMUST00000062437 Ensembl | MGI Sequence Detail 1134 Not Applicable  
polypeptide ENSMUSP00000049898 Ensembl | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 3
    cDNA 15
    Primer pair 6
    Other 5

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12893, MGI:2145773
References
more
  • Summaries
    All 52
    Developmental Gene Expression 16
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory