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Nkx2-6
Gene Detail
 Symbol
Name
ID
Nkx2-6
NK2 homeobox 6
MGI:97351
Synonyms Nkx-2.6, Nkx2.6, tinman, Tix
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:69171802-69175518 bp, + strand
From VEGA annotation of GRCm38

  3717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nkx2-6

Human
homologs
Human Homolog NKX2-6, NK2 homeobox 6
NCBI Gene ID 137814
neXtProt AC  NX_A6NCS4
Human Synonyms  CSX2, CTHM, NKX2F, NKX4-2
Human Chr (Location)  8p21.2; chr8:23702451-23706598 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NKX2-6
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut.
 
Interactions
Nkx2-6 interacts with 18 markers (Mir23a, Mir23b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell differentiation, embryonic heart tube development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (223)    Tissues (180)    Images (41)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 222
RT-PCR 1
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(12) Primer pair(3) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037541 (Evidence)
Ensembl Gene ModelENSMUSG00000044186 (Evidence)
Entrez Gene18092 (Evidence)
UniGene390691
DFCITC1586823
NIA Mouse Gene IndexU015804
Consensus CDS ProjectCCDS56968.1
International Mouse Knockout Project StatusNkx2-6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037541 VEGA Gene Model | MGI Sequence Detail 3717 C57BL/6J ±  kb
transcript OTTMUST00000096784 VEGA | MGI Sequence Detail 1134 Not Applicable 
polypeptide OTTMUSP00000054108 VEGA | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000011246 homeobox protein Nkx-2.6
References (Earliest) J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
(Latest) J:180986 Wei Q, et al., A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795
All references(49)
Other
accession IDs
MGD-MRK-12893, MGI:2145773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory