Nkx2-6
Gene Detail

Symbol Name ID

Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) MGI:97351

Synonyms

Nkx-2.6, Nkx2.6, tinman, Tix

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr14:69171576-69175539 bp, + strand From VEGA annotation of GRCm38   3964 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Nkx2-6

Human homologs

Human Homolog		NKX2-6, NK2 homeobox 6
NCBI Gene ID		137814
neXtProt AC		NX_A6NCS4
Human Synonyms		CSX2, NKX2F, NKX4-2
Human Chr (Location)		8p21.2; chr8:23559964-23564111 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NKX2-6

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell differentiation, embryonic heart tube development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (217)    Tissues (177)    Images (41)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	216
RT-PCR	1

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(2) cDNA(11) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037541 (Evidence)
Ensembl Gene Model	ENSMUSG00000044186 (Evidence)
Entrez Gene	18092 (Evidence)
UniGene	390691
DFCI	TC1586823
NIA Mouse Gene Index	U015804
Consensus CDS Project	CCDS56968.1
International Mouse Knockout Project Status	Nkx2-6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037541	VEGA Gene Model | MGI Sequence Detail	3964	C57BL/6J
transcript	OTTMUST00000096784	VEGA | MGI Sequence Detail	1381	Not Applicable
polypeptide	OTTMUSP00000054108	VEGA | MGI Sequence Detail	289	Not Applicable

All sequences(27) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000011246	homeobox protein Nkx-2.6

References

(Earliest) J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
(Latest) J:180986 Wei Q, et al., A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795
All references(49)

Other accession IDs

MGD-MRK-12893, MGI:2145773