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Nkx2-6 Gene Detail
Summary
  • Symbol
    Nkx2-6
  • Name
    NK2 homeobox 6
  • Synonyms
    Nkx-2.6, Nkx2.6, tinman, Tix
  • Feature Type
    protein coding gene
  • IDs
    MGI:97351
    NCBI Gene: 18092
Location & Maps
more
  • Sequence Map
    Chr14:69171802-69175518 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3717 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.01 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NKX2-6, NK2 homeobox 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NKX2-6, NK2 homeobox 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSX2, CTHM, NKX2F, NKX4-2
  • Links
    NCBI Gene ID: 137814
    neXtProt AC: NX_A6NCS4

  • Chr Location
    8p21.2; chr8:23702451-23706598 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NKX2-6 associations

Human Disease Mouse Models
       Conotruncal Heart Malformations; CTHM   OMIM: 217095
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Nkx2-6
  • Incidental Mutations
Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037541 VEGA Gene Model | MGI Sequence Detail 3717 C57BL/6J ±  kb
transcript OTTMUST00000096784 VEGA | MGI Sequence Detail 1134 Not Applicable  
polypeptide OTTMUSP00000054108 VEGA | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    Genomic 3
    cDNA 12
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12893, MGI:2145773
References
more
  • Summaries
    All 48
    Developmental Gene Expression 15
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:15282 Lints TJ, et al., Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants [published erratum appears in Development 1993 Nov;119(3):969]. Development. 1993 Oct;119(2):419-31
  • Latest
    J:180986 Wei Q, et al., A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory