Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; hypothalamus development; and tongue development. Acts upstream of or within several processes, including negative regulation of epithelial cell apoptotic process; pharyngeal system development; and positive regulation of epithelial cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and thymus. Human ortholog(s) of this gene implicated in familial atrial fibrillation and ventricular septal defect. Orthologous to human NKX2-6 (NK2 homeobox 6).