Nkx2-6 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx2-6
NK2 homeobox 6
MGI:97351

12 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Nkx2-5^tm1Siz/Nkx2-5⁺ Nkx2-6^tm1Siz/Nkx2-6^tm1Siz involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:69976
Nkx2-5^tm1Siz/Nkx2-5^tm1Siz Nkx2-6^tm1Siz/Nkx2-6⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	abnormal heart atrium morphology	J:69976
	abnormal pharynx morphology	J:69976
	absent atrioventricular cushions	J:69976
	embryonic lethality during organogenesis	J:69976
Nkx2-5^tm1Siz/Nkx2-5^tm1Siz Nkx2-6^tm1Siz/Nkx2-6^tm1Siz involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	abnormal heart atrium morphology	J:69976
	abnormal pharyngeal pouch morphology	J:69976
	absent atrioventricular cushions	J:69976
	decreased cell proliferation	J:69976
	embryonic growth retardation	J:69976
	embryonic lethality during organogenesis, complete penetrance	J:69976
	increased apoptosis	J:69976
	pericardial effusion	J:69976
	pharynx hypoplasia	J:69976

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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