Ngf
Gene Detail

Symbol Name ID

Ngf nerve growth factor MGI:97321

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(33)

Sequence Map

Chr3:102469928-102521013 bp, + strand From NCBI annotation of GRCm38   51086 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ngf

Human homologs

Human Homolog		NGF, nerve growth factor (beta polypeptide)
NCBI Gene ID		4803
neXtProt AC		NX_P01138
Human Synonyms		Beta-NGF, HSAN5, NGFB
Human Chr (Location)		1p13.1; chr1:115828537-115880857 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NGF

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mutants exhibit elevated pain threshold, loss of neurons in both sensory and sympathetic ganglia, but diminished apoptosis in the retina and spinal cord. Heterozygotes exhibit a substantially reduced number of sympathetic neurons.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	adult locomotory behavior, memory, ...
Component	extracellular region, extracellular space
Function	growth factor activity, nerve growth factor receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (64)    Tissues (49)    Images (11)
Theiler Stages: 21, 22, 23, 28

Assay Type	Results
RNA in situ	12
Northern blot	6
RT-PCR	46

cDNA source data(36)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(3) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027859 (Evidence)
Entrez Gene	18049 (Evidence)
UniGene	1259
DFCI	TC1584819, TC1708856
DoTS	DT.111055917, DT.524446
NIA Mouse Gene Index	U003647
PDB	1BET, 1BTG, 1SGF, 4EAX, 3IJ2
Consensus CDS Project	CCDS17687.1, CCDS51025.1
International Mouse Knockout Project Status	Ngf

Sequences

Length	Strain/Species
genomic	18049	NCBI Gene Model | MGI Sequence Detail	51086	C57BL/6J
transcript	NM_013609	RefSeq | MGI Sequence Detail	1187	Not Specified
polypeptide	P01139	UniProt | EBI | MGI Sequence Detail	241	Not Applicable

All sequences(30) RefSeq(4) UniProt(2)

Polymorphisms

All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs(292 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020425	Nerve growth factor, beta subunit
InterPro	IPR020437	Nerve growth factor, beta subunit, mammalian
InterPro	IPR019846	Nerve growth factor conserved site
InterPro	IPR020408	Nerve growth factor-like
InterPro	IPR002072	Nerve growth factor-related
Protein Ontology	PR:000011194	beta-nerve growth factor

Graphical View of Protein Domain Structure

References

(Earliest) J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
(Latest) J:194919 Nam J, et al., Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development. 2013 Apr;140(7):1475-85
All references(168)

Other accession IDs

MGD-MRK-12840