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Ngf
Gene Detail
Symbol

Name
ID
Ngf
nerve growth factor
MGI:97321
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr3:102469928-102521013 bp, + strand
From Ensembl annotation of GRCm38

  51086 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NGF
Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ngf

Human
homologs
NGF, nerve growth factor (beta polypeptide)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4803
neXtProt AC: NX_P01138

Human Synonyms: Beta-NGF, HSAN5, NGFB

Human Chr (Location): 1p13.1; chr1:115285916-115338384 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NGF

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants exhibit elevated pain threshold, loss of neurons in both sensory and sympathetic ganglia, but diminished apoptosis in the retina and spinal cord. Heterozygotes exhibit a substantially reduced number of sympathetic neurons.
 
Interactions
Ngf interacts with 57 markers (Mir32, Mir98, Mir128-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process adult locomotory behavior, cell-cell signaling, ...
Component cytoplasmic membrane-bounded vesicle, extracellular region, ...
Function enzyme inhibitor activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (64)    Tissues (49)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 12
Northern blot 6
RT-PCR 46
cDNA source data(36)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ngf ; ZFIN ngf    NEW 
Molecular
reagents
All nucleic(42) Genomic(3) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027859 (Evidence)
Entrez Gene 18049 (Evidence)
UniGene 1259
DFCI TC1584819, TC1708856
DoTS DT.111055917, DT.524446
NIA Mouse Gene Index U003647
PDB 1BET, 1BTG, 1SGF, 4EAX, 3IJ2
Consensus CDS Project CCDS17687.1, CCDS51025.1
International Mouse Phenotyping Consortium Status Ngf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027859 Ensembl Gene Model | MGI Sequence Detail 51086 C57BL/6J ±  kb
transcript ENSMUST00000106925 Ensembl | MGI Sequence Detail 1187 Not Applicable 
polypeptide ENSMUSP00000102538 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(10) UniProt(2)
Polymorphisms
All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020425 Nerve growth factor, beta subunit
InterPro IPR020437 Nerve growth factor, beta subunit, mammalian
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
Protein Ontology PR:000011194 beta-nerve growth factor
References
(Earliest) J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
(Latest) J:219373 Islam MN, et al., Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015 Mar;244(3):488-96
All references(184)
Other
accession IDs
MGD-MRK-12840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory