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Ngf
Gene Detail
 Symbol
Name
ID
Ngf
nerve growth factor
MGI:97321
Feature Type protein coding gene
Genetic Map
Chromosome 3
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(32)
Sequence Map
Chr3:102469928-102521013 bp, + strand
From NCBI annotation of GRCm38

  51086 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: nerve growth factor, subunit beta
Gene Tree: Ngf

Human
homologs
Human Homolog NGF, nerve growth factor (beta polypeptide)
NCBI Gene ID 4803
neXtProt AC  NX_P01138
Human Synonyms  Beta-NGF, HSAN5, NGFB
Human Chr (Location)  1p13.1; chr1:115285916-115338384 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NGF
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit elevated pain threshold, loss of neurons in both sensory and sympathetic ganglia, but diminished apoptosis in the retina and spinal cord. Heterozygotes exhibit a substantially reduced number of sympathetic neurons.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process adult locomotory behavior, extrinsic apoptotic signaling pathway in absence of ligand, ...
Component extracellular region, extracellular space
Function growth factor activity, nerve growth factor receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (64)    Tissues (49)    Images (11)
Theiler Stages: 21, 22, 23, 28
Assay TypeResults
RNA in situ 12
Northern blot 6
RT-PCR 46
cDNA source data(36)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(42) Genomic(3) cDNA(36) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027859 (Evidence)
Entrez Gene18049 (Evidence)
UniGene1259
DFCITC1584819, TC1708856
DoTSDT.111055917, DT.524446
NIA Mouse Gene IndexU003647
PDB1BET, 1BTG, 1SGF, 4EAX, 3IJ2
Consensus CDS ProjectCCDS17687.1, CCDS51025.1
International Mouse Knockout Project StatusNgf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18049 NCBI Gene Model | MGI Sequence Detail 51086 C57BL/6J ±  kb
transcript NM_013609 RefSeq | MGI Sequence Detail 1196 FVB/N 
polypeptide P01139 UniProt | EBI | MGI Sequence Detail 241 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(10) UniProt(2)
Polymorphisms All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020425 Nerve growth factor, beta subunit
InterPro IPR020437 Nerve growth factor, beta subunit, mammalian
InterPro IPR019846 Nerve growth factor conserved site
InterPro IPR020408 Nerve growth factor-like
InterPro IPR002072 Nerve growth factor-related
Protein Ontology PR:000011194 beta-nerve growth factor
Graphical View of Protein Domain Structure
References (Earliest) J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
(Latest) J:207835 Suo D, et al., Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci. 2014 Jan;17(1):36-45
All references(178)
Other
accession IDs
MGD-MRK-12840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory