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Ngf Gene Detail
Summary
  • Symbol
    Ngf
  • Name
    nerve growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:97321
    NCBI Gene: 18049
  • Gene Overview
    MyGene.info: NGF
Location & Maps
more
  • Sequence Map
    Chr3:102469919-102521013 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51095 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NGF, nerve growth factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NGF, nerve growth factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Beta-NGF, HSAN5, NGFB
  • Links
    NCBI Gene ID: 4803
    neXtProt AC: NX_P01138

  • Chr Location
    1p13.1; chr1:115285916-115338384 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NGF associations

Human Disease Mouse Models
       Neuropathy, Hereditary Sensory and Autonomic, Type V; HSAN5   OMIM: 608654
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 5 alleles in 6 genetic backgrounds
    42 phenotypes from multigenic genotypes
    3 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    4
  • Genomic Mutations
    2 involving Ngf
  • Incidental Mutations
Homozygous null mutants exhibit elevated pain threshold, loss of neurons in both sensory and sympathetic ganglia, but diminished apoptosis in the retina and spinal cord. Heterozygotes exhibit a substantially reduced number of sympathetic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054689 VEGA Gene Model | MGI Sequence Detail 51095 C57BL/6J ±  kb
transcript OTTMUST00000135567 VEGA | MGI Sequence Detail 1187 Not Applicable  
polypeptide OTTMUSP00000071719 VEGA | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    316 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 3
    cDNA 36
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12840
References
more
  • Summaries
    All 185
    Developmental Gene Expression 36
    Diseases 1
    Gene Ontology 24
    Phenotypes 60
  • Earliest
    J:135487 Bothwell MA, et al., Dissociation equilibrium constant of beta nerve growth factor. J Biol Chem. 1977 Dec 10;252(23):8532-6
  • Latest
    J:226826 Huang S, et al., Extrinsic and intrinsic signals converge on the Runx1/CBFbeta transcription factor for nonpeptidergic nociceptor maturation. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory