Nfix
Gene Detail

Symbol Name ID

Nfix nuclear factor I/X MGI:97311

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.02 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:84699876-84800344 bp, - strand From VEGA annotation of GRCm38   100469 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1872  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: nuclear factor 1
Gene Tree: Nfix

Human homologs

Human Homolog		NFIX, nuclear factor I/X (CCAAT-binding transcription factor)
NCBI Gene ID		4784
neXtProt AC		NX_Q14938
Human Synonyms		MRSHSS, NF1A, SOTOS2
Human Chr (Location)		19p13.3; chr19:13106584-13209610 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NFIX

Alleles and phenotypes

All alleles(15) : Targeted(4) Gene trapped(11)
 

Mice homozygous for a mutation in this gene display postnatal lethality, hydrocephalus, partial agenesis of the corpus callosum, deformation of the spine due to delayed vertebral body ossification, degeneration of intervertebral disks, decreased mineralization and impaired endochondral ossification.

 
Human Diseases Modeled Using Mouse Nfix (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	astrocyte differentiation, cerebellar granule cell differentiation, ...
Component	intracellular, nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (228)    Tissues (185)    Images (31)
Theiler Stages: 13, 14, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	203
Northern blot	8
RT-PCR	17

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(5) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000022188 (Evidence)
Ensembl Gene Model	ENSMUSG00000001911 (Evidence)
Entrez Gene	18032 (Evidence)
DFCI	TC1578529, TC1589434, TC1603278, TC1751072
DoTS	DT.101387031, DT.110902485, DT.110902586, DT.493548, DT.94125027
NIA Mouse Gene Index	U030037
Consensus CDS Project	CCDS40411.1, CCDS40412.1, CCDS40413.1
International Mouse Knockout Project Status	Nfix

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022188	VEGA Gene Model | MGI Sequence Detail	100469	C57BL/6J
transcript	OTTMUST00000052707	VEGA | MGI Sequence Detail	5476	Not Applicable
polypeptide	OTTMUSP00000025025	VEGA | MGI Sequence Detail	494	Not Applicable

All sequences(69) RefSeq(6) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(396 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000647	CTF transcription factor/nuclear factor 1
InterPro	IPR019739	CTF transcription factor/nuclear factor 1, conserved site
InterPro	IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro	IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
InterPro	IPR003619	MAD homology 1, Dwarfin-type
Protein Ontology	PR:000011177	nuclear factor 1 X-type

References

(Earliest) J:19433 Scherthan H, et al., Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH. Genomics. 1994 Jul 1;22(1):247-9
(Latest) J:187997 Chamberlain CM, et al., Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise. Hum Mol Genet. 2012 Nov 1;21(21):4645-54
All references(59)

Other accession IDs

MGD-MRK-12828