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Nfix
Gene Detail
Symbol

Name
ID
Nfix
nuclear factor I/X
MGI:97311
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.02 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:84699876-84800344 bp, - strand
From VEGA annotation of GRCm38

  100469 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1872  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFIX
Protein SuperFamily: nuclear factor 1
Gene Tree: Nfix

Human
homologs
NFIX, nuclear factor I/X (CCAAT-binding transcription factor)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4784
neXtProt AC: NX_Q14938

Human Synonyms: MRSHSS, NF1A, SOTOS2

Human Chr (Location): 19p13.3; chr19:12995756-13098796 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NFIX

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(11) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a mutation in this gene display postnatal lethality, hydrocephalus, partial agenesis of the corpus callosum, deformation of the spine due to delayed vertebral body ossification, degeneration of intervertebral disks, decreased mineralization and impaired endochondral ossification.
 
Human Diseases Modeled in Mice Using Nfix (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Nfix interacts with 421 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process astrocyte differentiation, cerebellar granule cell differentiation, ...
Component intracellular, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (228)    Tissues (188)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 203
Northern blot 8
RT-PCR 17
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfix ; ZFIN nfixa, nfixb    NEW 
Molecular
reagents
All nucleic(32) Genomic(5) cDNA(22) Primer pair(4) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000022188 (Evidence)
Ensembl Gene Model ENSMUSG00000001911 (Evidence)
Entrez Gene 18032 (Evidence)
DFCI TC1578529, TC1589434, TC1603278, TC1751072
DoTS DT.101387031, DT.110902485, DT.110902586, DT.493548, DT.94125027, DT.94349983
NIA Mouse Gene Index U030037
Consensus CDS Project CCDS40411.1, CCDS40412.1, CCDS40413.1
International Mouse Phenotyping Consortium Status Nfix
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022188 VEGA Gene Model | MGI Sequence Detail 100469 C57BL/6J ±  kb
transcript OTTMUST00000052707 VEGA | MGI Sequence Detail 5476 Not Applicable 
polypeptide OTTMUSP00000025025 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(30) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(552 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011177 nuclear factor 1 X-type
References
(Earliest) J:19433 Scherthan H, et al., Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH. Genomics. 1994 Jul 1;22(1):247-9
(Latest) J:217046 Magnani D, et al., Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb Cortex. 2014 Jan;24(1):186-98
All references(66)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory