|
Symbol Name ID |
Nfix
nuclear factor I/X MGI:97311 |
| Darker colors indicate more annotations |
| Human Phenotypes | Frontal bossing |
Prominent occiput |
Craniosynostosis |
Dolichocephaly |
Short mandibular rami |
Microretrognathia |
Mandibular prognathia |
Retrognathia |
Hyperplasia of the premaxilla |
Prominence of the premaxilla |
Shallow orbits |
Macrocephaly |
Wormian bones |
Bowing of the long bones |
Clinodactyly of the 5th finger |
Short distal phalanx of finger |
Bullet-shaped middle phalanges of the hand |
Prominent fingertip pads |
Long fingers |
Slender finger |
Hallux valgus |
Coxa valga |
Coxa vara |
Distal widening of metacarpals |
Joint hypermobility |
Decreased hip abduction |
Accelerated skeletal maturation |
Increased susceptibility to fractures |
Recurrent fractures |
Slender long bone |
Hip dysplasia |
Large sternal ossification centers |
Short sternum |
Pectus excavatum |
Thoracic kyphosis |
Thoracic scoliosis |
Kyphosis |
Kyphoscoliosis |
Scoliosis |
Hypoplasia of the odontoid process |
Atlantoaxial dislocation |
Reduced bone mineral density |
| Disease(s) Associated with NFIX | ||||||||||||||||||||||||||||||||||||||||||
| Marshall-Smith syndrome | ||||||||||||||||||||||||||||||||||||||||||
| Sotos syndrome 2 |
| Mouse Phenotypes | abnormal craniofacial bone morphology |
abnormal cranial suture morphology |
domed cranium |
abnormal long bone epiphyseal plate morphology |
abnormal long bone epiphyseal plate proliferative zone |
abnormal long bone hypertrophic chondrocyte zone |
increased long bone epiphyseal plate size |
abnormal intervertebral disk morphology |
intervertebral disk degeneration |
abnormal spine curvature |
kyphosis |
lordosis |
scoliosis |
abnormal vertebral body morphology |
decreased compact bone thickness |
decreased trabecular bone mass |
decreased trabecular bone thickness |
abnormal bone mineralization |
delayed endochondral bone ossification |
delayed bone ossification |
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| Availability | Mouse Genotype | ||||||||||||||||||||
| Nfixtm1Aes/Nfixtm1Aes | |||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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