About   Help   FAQ
Myl3
Gene Detail
Symbol

Name
ID
Myl3
myosin, light polypeptide 3
MGI:97268
STS
Synonyms
alkali, MLC1s, MLC1v, Mylc, slow skeletal, ventricular
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:110763646-110769804 bp, + strand
From VEGA annotation of GRCm38

  6159 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYL3
Gene Tree: Myl3

Human
homologs
MYL3, myosin, light chain 3, alkali; ventricular, skeletal, slow
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4634
neXtProt AC: NX_P08590

Human Synonyms: CMH8, MLC1SB, MLC1V, VLC1

Human Chr (Location): 3p21.3-p21.2; chr3:46857867-46863483 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYL3

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Myl3 interacts with 27 markers (Mir30c-1, Mir30c-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cardiac muscle contraction, regulation of striated muscle contraction, ...
Component A band, I band, ...
Function actin monomer binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (163)    Tissues (31)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 160
Western blot 3
cDNA source data(239)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myl3    NEW 
Molecular
reagents
All nucleic(246) Genomic(3) cDNA(239) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016497 (Evidence)
Ensembl Gene Model ENSMUSG00000059741 (Evidence)
Entrez Gene 17897 (Evidence)
UniGene 7353
DFCI TC1572453, TC1751828
DoTS DT.535942
NIA Mouse Gene Index U040726
Consensus CDS Project CCDS23571.1
International Mouse Phenotyping Consortium Status Myl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016497 VEGA Gene Model | MGI Sequence Detail 6159 C57BL/6J ±  kb
transcript OTTMUST00000039826 VEGA | MGI Sequence Detail 943 Not Applicable 
polypeptide OTTMUSP00000017767 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000003220 myosin light chain 3
References
(Earliest) J:7759 Robert B, et al., Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature. 1985 Mar 14-20;314(6007):181-3
(Latest) J:216142 Amann R, et al., The FgfrL1 receptor is required for development of slow muscle fibers. Dev Biol. 2014 Oct 15;394(2):228-41
All references(66)
Other
accession IDs
MGD-MRK-12766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory