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Myl3 Gene Detail
Summary
  • Symbol
    Myl3
  • Name
    myosin, light polypeptide 3
  • Synonyms
    alkali, MLC1s, MLC1v, Mylc, slow skeletal, ventricular
  • Feature Type
    protein coding gene
  • IDs
    MGI:97268
    NCBI Gene: 17897
  • Gene Overview
    MyGene.info: MYL3
Location & Maps
more
  • Sequence Map
    Chr9:110741861-110769798 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27938 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 60.69 cM
  • Mapping Data
    8 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    MYL3, myosin light chain 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYL3, myosin light chain 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMH8, MLC1SB, MLC1V, MLC-lV/sb, VLC1, VLCl
  • Links
    NCBI Gene ID: 4634
    neXtProt AC: NX_P08590

  • Chr Location
    3p21.31; chr3:46857867-46863483 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20099
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYL3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYL3 associations

Human Disease Mouse Models
       Cardiomyopathy, Familial Hypertrophic, 8; CMH8   OMIM: 608751
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016497 VEGA Gene Model | MGI Sequence Detail 27938 C57BL/6J ±  kb
transcript OTTMUST00000039826 VEGA | MGI Sequence Detail 937 Not Applicable  
polypeptide OTTMUSP00000017767 VEGA | MGI Sequence Detail 204 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    103 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 245
    Genomic 3
    cDNA 239
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-12766
References
more
  • Summaries
    All 63
    Developmental Gene Expression 31
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:7759 Robert B, et al., Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature. 1985 Mar 14-20;314(6007):181-3
  • Latest
    J:230021 Peng Y, et al., Critical roles of miRNA-mediated regulation of TGFbeta signalling during mouse cardiogenesis. Cardiovasc Res. 2014 Jul 15;103(2):258-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory