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Myl3
Gene Detail
Symbol

Name
ID
Myl3
myosin, light polypeptide 3
MGI:97268
STS
Synonyms
alkali, MLC1s, MLC1v, Mylc, slow skeletal, ventricular
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:110763646-110769804 bp, + strand
From VEGA annotation of GRCm38

  6159 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myl3

Human
homologs
Human Homolog MYL3, myosin, light chain 3, alkali; ventricular, skeletal, slow
NCBI Gene ID 4634
neXtProt AC  NX_P08590
Human Synonyms  CMH8, MLC1SB, MLC1V, VLC1
Human Chr (Location)  3p21.3-p21.2; chr3:46857867-46863483 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Myl3 interacts with 27 markers (Mir30c-1, Mir30c-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cardiac muscle contraction, metabolic process, ...
Component A band, I band, ...
Function actin monomer binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (162)    Tissues (30)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 159
Western blot 3
cDNA source data(239)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(246) Genomic(3) cDNA(239) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016497 (Evidence)
Ensembl Gene ModelENSMUSG00000059741 (Evidence)
Entrez Gene17897 (Evidence)
UniGene7353
DFCITC1572453, TC1751828
DoTSDT.535942
NIA Mouse Gene IndexU040726
Consensus CDS ProjectCCDS23571.1
International Mouse Knockout Project StatusMyl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016497 VEGA Gene Model | MGI Sequence Detail 6159 C57BL/6J ±  kb
transcript OTTMUST00000039826 VEGA | MGI Sequence Detail 943 Not Applicable 
polypeptide OTTMUSP00000017767 VEGA | MGI Sequence Detail 204 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000003220 myosin light chain 3
References
(Earliest) J:7759 Robert B, et al., Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature. 1985 Mar 14-20;314(6007):181-3
(Latest) J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
All references(70)
Other
accession IDs
MGD-MRK-12766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory