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Myl3 Gene Detail
Summary
  • Symbol
    Myl3
  • Name
    myosin, light polypeptide 3
  • Synonyms
    alkali, MLC1s, MLC1v, Mylc, slow skeletal, ventricular
  • Feature Type
    protein coding gene
  • IDs
    MGI:97268
    NCBI Gene: 17897
  • Gene Overview
    MyGene.info: MYL3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:110763681-110769794 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 60.69 cM
  • Mapping Data
    8 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97268
protein coding gene Chr9:110741861-110769798 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035355
protein coding gene Chr9:112913838-112944406 (+)
A/J MGP_AJ_G0035336
protein coding gene Chr9:108802620-108830455 (+)
AKR/J MGP_AKRJ_G0035267
protein coding gene Chr9:111505048-111535141 (+)
BALB/cJ MGP_BALBcJ_G0035331
protein coding gene Chr9:108551338-108579928 (+)
C3H/HeJ MGP_C3HHeJ_G0035039
protein coding gene Chr9:112011238-112045699 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035853
protein coding gene Chr9:115983371-116014251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032739
protein coding gene Chr9:106020713-106048404 (+)
CAST/EiJ MGP_CASTEiJ_G0034345
protein coding gene Chr9:111805958-111835425 (+)
CBA/J MGP_CBAJ_G0035006
protein coding gene Chr9:120296722-120327551 (+)
DBA/2J MGP_DBA2J_G0035165
protein coding gene Chr9:108266653-108294702 (+)
FVB/NJ MGP_FVBNJ_G0035112
protein coding gene Chr9:107093938-107123140 (+)
LP/J MGP_LPJ_G0035244
protein coding gene Chr9:113204731-113235687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035152
protein coding gene Chr9:121630768-121659292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035873
protein coding gene Chr9:111848816-111879248 (+)
PWK/PhJ MGP_PWKPhJ_G0034052
protein coding gene Chr9:108511330-108541866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033887
protein coding gene Chr9:111927114-111957477 (+)
WSB/EiJ MGP_WSBEiJ_G0034466
protein coding gene Chr9:111713038-111745698 (+)



Homology
more
  • Human Ortholog
    MYL3, myosin light chain 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYL3, myosin light chain 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMH8, MLC1SB, MLC1V, MLC-lV/sb, VLC1, VLCl
  • Links
    NCBI Gene ID: 4634
    neXtProt AC: NX_P08590
    UniProt: P08590

  • Chr Location
    3p21.31; chr3:46857867-46863483 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20099
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYL3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MYL3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17897 NCBI Gene Model | MGI Sequence Detail 6114 C57BL/6J ±  kb
    transcript NM_010859 RefSeq | MGI Sequence Detail 909 C57BL/6  
    polypeptide P09542 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      Genomic 3
      cDNA 240
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12766
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:7759 Robert B, et al., Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross. Nature. 1985 Mar 14-20;314(6007):181-3
    • Latest
      J:273025 Moreau JLM, et al., Gene-environment interaction impacts on heart development and embryo survival. Development. 2019 Feb 20;146(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/01/2019
    MGI 6.14
    The Jackson Laboratory