About   Help   FAQ
Mpo Gene Detail
Summary
  • Symbol
    Mpo
  • Name
    myeloperoxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97137
    NCBI Gene: 17523
  • Gene Overview
    MyGene.info: MPO
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87793784-87804412 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.22 cM, cytoband C
  • Mapping Data
    34 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97137
protein coding gene Chr11:87793581-87804413 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018912
protein coding gene Chr11:89426197-89438078 (+)
A/J MGP_AJ_G0018879
protein coding gene Chr11:85979739-85991108 (+)
AKR/J MGP_AKRJ_G0018849
protein coding gene Chr11:88553855-88564936 (+)
BALB/cJ MGP_BALBcJ_G0018852
protein coding gene Chr11:86380895-86392014 (+)
C3H/HeJ MGP_C3HHeJ_G0018666
protein coding gene Chr11:88594371-88608018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019304
protein coding gene Chr11:92142850-92153785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016937
protein coding gene Chr11:83007979-83018799 (+)
CAST/EiJ MGP_CASTEiJ_G0018221
protein coding gene Chr11:89289184-89304030 (+)
CBA/J MGP_CBAJ_G0018637
protein coding gene Chr11:96011144-96029986 (+)
DBA/2J MGP_DBA2J_G0018745
protein coding gene Chr11:85533646-85544391 (+)
FVB/NJ MGP_FVBNJ_G0018734
protein coding gene Chr11:85039488-85050532 (+)
LP/J MGP_LPJ_G0018815
protein coding gene Chr11:89918540-89930596 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018761
protein coding gene Chr11:96050590-96061951 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019344
protein coding gene Chr11:88791386-88803539 (+)
PWK/PhJ MGP_PWKPhJ_G0017991
protein coding gene Chr11:86382787-86394240 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017784
protein coding gene Chr11:88350529-88362822 (+)
WSB/EiJ MGP_WSBEiJ_G0018272
protein coding gene Chr11:88684108-88695588 (+)



Homology
more
  • Human Ortholog
    MPO, myeloperoxidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPO, myeloperoxidase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4353
    neXtProt AC: NX_P05164
    UniProt: P05164

  • Chr Location
    17q22; chr17:58269856-58280935 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MPO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17523 NCBI Gene Model | MGI Sequence Detail 10629 C57BL/6J ±  kb
transcript NM_010824 RefSeq | MGI Sequence Detail 2570 C57BL/6NCrl  
polypeptide P11247 UniProt | EBI | MGI Sequence Detail 718 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 266
    Genomic 4
    cDNA 253
    Primer pair 5
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12530
References
more
  • Summaries
    All 156
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 11
    Phenotypes 63
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265328 Yakubenko VP, et al., Oxidative modifications of extracellular matrix promote the second wave of inflammation via beta2 integrins. Blood. 2018 Jul 5;132(1):78-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory