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Mpo Gene Detail
Summary
  • Symbol
    Mpo
  • Name
    myeloperoxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97137
    NCBI Gene: 17523
  • Gene Overview
    MyGene.info: MPO
Location & Maps
more
  • Sequence Map
    Chr11:87793581-87804413 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10833 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MPO, myeloperoxidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MPO, myeloperoxidase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 4353
    neXtProt AC: NX_P05164

  • Chr Location
    17q23.1; chr17:58269855-58284313 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mpo mouse models; 2 with human MPO associations

Human Disease Mouse Models
       Myeloperoxidase Deficiency; MPOD   OMIM: 254600 View 1 model
       Alzheimer Disease; AD   OMIM: 104300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    4 involving Mpo
  • Incidental Mutations
Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001441 VEGA Gene Model | MGI Sequence Detail 10833 C57BL/6J ±  kb
transcript OTTMUST00000002819 VEGA | MGI Sequence Detail 2409 Not Applicable  
polypeptide OTTMUSP00000034233 VEGA | MGI Sequence Detail 718 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    165 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 265
    Genomic 4
    cDNA 252
    Primer pair 5
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12530
References
more
  • Summaries
    All 123
    Developmental Gene Expression 12
    Diseases 2
    Gene Ontology 9
    Phenotypes 55
  • Earliest
    J:30932 Morishita K, et al., Molecular cloning and characterization of cDNA for human myeloperoxidase. J Biol Chem. 1987 Mar 15;262(8):3844-51
  • Latest
    J:230129 Wang Q, et al., Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. 2014 Dec;63(12):4172-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory