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Mpo
Gene Detail
 Symbol
Name
ID
Mpo
myeloperoxidase
MGI:97137
STS D11Mit38, D11Mit39, D11Nds17
Feature Type protein coding gene
Genetic Map
Chromosome 11
52.22 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr11:87793581-87804413 bp, + strand
From VEGA annotation of GRCm38

  10833 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55450  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: myeloperoxidase
Gene Tree: Mpo

Human
homologs
Human Homolog MPO, myeloperoxidase
NCBI Gene ID 4353
neXtProt AC  NX_P05164
Human Chr (Location)  17q23.1; chr17:58269856-58280935 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MPO
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Mpo (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation.
 
Human Diseases Modeled Using Mouse Mpo (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Mpo interacts with 55 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process defense response to fungus, hydrogen peroxide catabolic process, ...
Component azurophil granule, extracellular space, ...
Function heme binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (242)    Tissues (105)    Images (30)
Theiler Stages: 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 222
Northern blot 8
RT-PCR 12
cDNA source data(252)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(265) Genomic(4) cDNA(252) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001441 (Evidence)
Ensembl Gene ModelENSMUSG00000009350 (Evidence)
Entrez Gene17523 (Evidence)
UniGene4668
DFCITC1573526, TC1735371
DoTSDT.101122202, DT.101385550, DT.110547353, DT.97395183
NIA Mouse Gene IndexU013150
EC1.11.2.2
Consensus CDS ProjectCCDS25217.1
International Mouse Knockout Project StatusMpo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001441 VEGA Gene Model | MGI Sequence Detail 10833 C57BL/6J ±  kb
transcript OTTMUST00000002817 VEGA | MGI Sequence Detail 2750 Not Applicable 
polypeptide OTTMUSP00000001371 VEGA | MGI Sequence Detail 718 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(12) UniProt(6)
Polymorphisms All PCR and RFLP(7) : PCR(3) RFLP(4) SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010255 Haem peroxidase
InterPro IPR002007 Haem peroxidase, animal
InterPro IPR019791 Haem peroxidase, animal, subgroup
Protein Ontology PR:000010543 myeloperoxidase
References (Earliest) J:30932 Morishita K, et al., Molecular cloning and characterization of cDNA for human myeloperoxidase. J Biol Chem. 1987 Mar 15;262(8):3844-51
(Latest) J:206250 Steinbach K, et al., Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs. J Immunol. 2013 Nov 1;191(9):4531-9
All references(126)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory