Mpo
Gene Detail

Symbol Name ID

Mpo myeloperoxidase MGI:97137

STS

D11Mit38, D11Mit39, D11Nds17

Feature Type

protein coding gene

Genetic Map

Chromosome 11

52.22 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(34)

Sequence Map

Chr11:87793581-87804413 bp, + strand From VEGA annotation of GRCm38   10833 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55450  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: myeloperoxidase
Gene Tree: Mpo

Human homologs

Human Homolog		MPO, myeloperoxidase
NCBI Gene ID		4353
neXtProt AC		NX_P05164
Human Chr (Location)		17q23.1; chr17:56347217-56358296 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MPO

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous inactivation of this gene causes neutrophil dysfunction and decreased resistance to fungal infection with Candida, and may lead to enhanced atherosclerosis, reduced neutrophil-mediated lysis of muscle cells, decreased resistance to EAE, and altered asbestos-induced lung inflammation.

 
Human Diseases Modeled Using Mouse Mpo (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	defense response to fungus, hydrogen peroxide catabolic process, ...
Component	extracellular space, lysosome, ...
Function	heme binding, heparin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (242)    Tissues (105)    Images (30)
Theiler Stages: 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	222
Northern blot	8
RT-PCR	12

cDNA source data(251)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(264) Genomic(4) cDNA(251) Primer pair(5) Other(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001441 (Evidence)
Ensembl Gene Model	ENSMUSG00000009350 (Evidence)
Entrez Gene	17523 (Evidence)
UniGene	4668
DFCI	TC1573526, TC1735371
DoTS	DT.101122202, DT.101385550, DT.110547353, DT.97395183
NIA Mouse Gene Index	U013150
EC	1.11.2.2
Consensus CDS Project	CCDS25217.1
International Mouse Knockout Project Status	Mpo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001441	VEGA Gene Model | MGI Sequence Detail	10833	C57BL/6J
transcript	OTTMUST00000002819	VEGA | MGI Sequence Detail	2409	Not Applicable
polypeptide	OTTMUSP00000034233	VEGA | MGI Sequence Detail	718	Not Applicable

All sequences(52) RefSeq(2) UniProt(7)

Polymorphisms

All PCR and RFLP(7) : PCR(3) RFLP(4) SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010255	Haem peroxidase
InterPro	IPR002007	Haem peroxidase, animal
InterPro	IPR019791	Haem peroxidase, animal, subgroup
Protein Ontology	PR:000010543	myeloperoxidase

References

(Earliest) J:30932 Morishita K, et al., Molecular cloning and characterization of cDNA for human myeloperoxidase. J Biol Chem. 1987 Mar 15;262(8):3844-51
(Latest) J:194538 Xiao H, et al., Genetically determined severity of anti-myeloperoxidase glomerulonephritis. Am J Pathol. 2013 Apr;182(4):1219-26
All references(117)

Other accession IDs

MGD-MRK-12530