Mmp3
Gene Detail

Symbol Name ID

Mmp3 matrix metallopeptidase 3 MGI:97010

Synonyms

progelatinase, SLN1, SLN-1, Stmy1, Str1, STR-1, stromelysin 1, stromelysin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:7445822-7455972 bp, + strand From Ensembl annotation of GRCm38   10151 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp3

Human homologs

Human Homolog		MMP3, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NCBI Gene ID		4314
neXtProt AC		NX_P08254
Human Synonyms		CHDS6, MMP-3, SL-1, STMY, STMY1, STR1
Human Chr (Location)		11q22.3; chr11:102706528-102714342 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for disrutptions in this gene display abnormalities of the immune system as well as minor structural abnormalities in the neuromuscular junction.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular response to amino acid stimulus, collagen catabolic process, ...
Component	cell body, dendrite, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (37)    Tissues (23)    Images (5)
Theiler Stages: 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	5
Western blot	7
RT-PCR	21

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(4) cDNA(13) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000043613 (Evidence)
Entrez Gene	17392 (Evidence)
UniGene	4993
DFCI	TC1582408
DoTS	DT.40168481
NIA Mouse Gene Index	U053453
EC	3.4.24.17
Consensus CDS Project	CCDS22806.1
International Mouse Knockout Project Status	Mmp3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000043613	Ensembl Gene Model | MGI Sequence Detail	10151	C57BL/6J
transcript	ENSMUST00000034497	Ensembl | MGI Sequence Detail	1798	Not Applicable
polypeptide	ENSMUSP00000034497	Ensembl | MGI Sequence Detail	479	Not Applicable

All sequences(19) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR016293	Peptidase M10A, metazoans
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010488	stromelysin-1

References

(Earliest) J:2890 Hammani K, et al., Cloning and sequencing of a cDNA encoding mouse stromelysin 1. Gene. 1992 Oct 21;120(2):321-2
(Latest) J:194963 Ijichi K, et al., MMP-3 mediates psychosine-induced globoid cell formation: Implications for leukodystrophy pathology. Glia. 2013 May;61(5):765-77
All references(108)

Other accession IDs

MGD-MRK-12280, MGD-MRK-14627