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Mmp3
Gene Detail
 Symbol
Name
ID
Mmp3
matrix metallopeptidase 3
MGI:97010
Synonyms progelatinase, SLN1, SLN-1, Stmy1, Str1, STR-1, stromelysin 1, stromelysin-1
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:7445822-7455972 bp, + strand
From Ensembl annotation of GRCm38

  10151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 western clawed frog

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp3

Human
homologs
Human Homolog MMP3, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NCBI Gene ID 4314
neXtProt AC  NX_P08254
Human Synonyms  CHDS6, MMP-3, SL-1, STMY, STMY1, STR1
Human Chr (Location)  11q22.3; chr11:102835797-102843611 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MMP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disrutptions in this gene display abnormalities of the immune system as well as minor structural abnormalities in the neuromuscular junction.
 
Interactions
Mmp3 interacts with 69 markers (Mir101a, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to amino acid stimulus, collagen catabolic process, ...
Component cell body, dendrite, ...
Function calcium ion binding, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (37)    Tissues (24)    Images (5)
Theiler Stages: 17, 19, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 5
Western blot 7
RT-PCR 21
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(13) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000043613 (Evidence)
Entrez Gene17392 (Evidence)
UniGene4993
DFCITC1582408
DoTSDT.40168481
NIA Mouse Gene IndexU053453
EC3.4.24.17
Consensus CDS ProjectCCDS22806.1
International Mouse Knockout Project StatusMmp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043613 Ensembl Gene Model | MGI Sequence Detail 10151 C57BL/6J ±  kb
transcript ENSMUST00000034497 Ensembl | MGI Sequence Detail 1798 Not Applicable 
polypeptide ENSMUSP00000034497 Ensembl | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)    SNPs within 2kb including multiple locations(80)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010488 stromelysin-1
References (Earliest) J:2890 Hammani K, et al., Cloning and sequencing of a cDNA encoding mouse stromelysin 1. Gene. 1992 Oct 21;120(2):321-2
(Latest) J:201913 Kessenbrock K, et al., A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 5;13(3):300-13
All references(113)
Other
accession IDs
MGD-MRK-12280, MGD-MRK-14627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory