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Mmp3
Gene Detail
Symbol

Name
ID
Mmp3
matrix metallopeptidase 3
MGI:97010
Synonyms
progelatinase, SLN1, SLN-1, Stmy1, Str1, STR-1, stromelysin 1, stromelysin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:7445822-7455972 bp, + strand
From Ensembl annotation of GRCm38

  10151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 western clawed frog

HCOP human homology predictions: MMP3
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp3

Human
homologs
MMP3, matrix metallopeptidase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4314
neXtProt AC: NX_P08254

Human Synonyms: CHDS6, MMP-3, SL-1, STMY, STMY1, STR1

Human Chr (Location): 11q22.3; chr11:102835797-102843611 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MMP3

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disrutptions in this gene display abnormalities of the immune system as well as minor structural abnormalities in the neuromuscular junction.
 
Interactions
Mmp3 interacts with 68 markers (Mir101a, Mir103-1, Mir103-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cellular response to amino acid stimulus, collagen catabolic process, ...
Component cell body, cytosol, ...
Function calcium ion binding, endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (37)    Tissues (24)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 5
Western blot 7
RT-PCR 21
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MMP10 ; Xenbase mmp3    NEW 
Molecular
reagents
All nucleic(23) Genomic(4) cDNA(13) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000043613 (Evidence)
Entrez Gene 17392 (Evidence)
UniGene 4993
DFCI TC1582408
DoTS DT.40168481
NIA Mouse Gene Index U053453
EC 3.4.24.17
Consensus CDS Project CCDS22806.1
International Mouse Phenotyping Consortium Status Mmp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043613 Ensembl Gene Model | MGI Sequence Detail 10151 C57BL/6J ±  kb
transcript ENSMUST00000034497 Ensembl | MGI Sequence Detail 1798 Not Applicable 
polypeptide ENSMUSP00000034497 Ensembl | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)    SNPs within 2kb including multiple locations(80)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, stromelysin-type
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
InterPro IPR028700 Stromelysin 1
Protein Ontology PR:000010488 stromelysin-1
References
(Earliest) J:2890 Hammani K, et al., Cloning and sequencing of a cDNA encoding mouse stromelysin 1. Gene. 1992 Oct 21;120(2):321-2
(Latest) J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14
All references(116)
Other
accession IDs
MGD-MRK-12280, MGD-MRK-14627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory