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Mip
Gene Detail
Symbol

Name
ID
Mip
major intrinsic protein of eye lens fiber
MGI:96990
Synonyms
Aqp0, aquaporin 0, Cts, lens opacity, Lop, MIP26, shrivelled, Svl
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.49 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr10:128225838-128231812 bp, + strand
From VEGA annotation of GRCm38

  5975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40627  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Mip

Human
homologs
Human Homolog MIP, major intrinsic protein of lens fiber
NCBI Gene ID 4284
neXtProt AC  NX_P30301
Human Synonyms  AQP0, CTRCT15, LIM1, MIP26, MP26
Human Chr (Location)  12q13; chr12:56449502-56454651 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MIP
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(21) Radiation induced(1) Spontaneous(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes have microphthalmia and lens opacity. Other defects may include degeneration of lens fiber cells, vacuolization of lens fibers and reduced gamma:alpha crystallin ratio. Heterozygotes have less severe forms of lens cataract and microphthalmia.
 
Human Diseases Modeled Using Mouse Mip (1)    Alleles Annotated to Human Diseases(5)   
Interactions
Mip interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process canalicular bile acid transport, cell communication, ...
Component cell junction, gap junction, ...
Function channel activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (92)    Tissues (77)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
Western blot 5
RT-PCR 58
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024337 (Evidence)
Ensembl Gene ModelENSMUSG00000025389 (Evidence)
Entrez Gene17339 (Evidence)
DFCITC1582418
DoTSDT.110625752, DT.40157474
Consensus CDS ProjectCCDS24265.1
International Mouse Knockout Project StatusMip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024337 VEGA Gene Model | MGI Sequence Detail 5975 C57BL/6J ±  kb
transcript OTTMUST00000059620 VEGA | MGI Sequence Detail 2144 Not Applicable 
polypeptide OTTMUSP00000029013 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000010911 lens fiber major intrinsic protein
References
(Earliest) J:285 PAGET OE, [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse.]. Z Indukt Abstamm Vererbungsl. 1953;85(2):238-44
(Latest) J:209511 Basu S, et al., alpha6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014 Feb 14;289(7):3842-55
All references(103)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-10701, MGD-MRK-11842, MGD-MRK-12240, MGD-MRK-14658, MGD-MRK-1767, MGD-MRK-2244, MGI:88560, MGI:96076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory