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Mip
Gene Detail
Symbol

Name
ID
Mip
major intrinsic protein of eye lens fiber
MGI:96990
Synonyms
Aqp0, aquaporin 0, Cts, lens opacity, Lop, MIP26, shrivelled, Svl
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.49 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr10:128225838-128231812 bp, + strand
From VEGA annotation of GRCm38

  5975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40627  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MIP
Protein SuperFamily: aquaporin
Gene Tree: Mip

Human
homologs
MIP, major intrinsic protein of lens fiber
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4284
neXtProt AC: NX_P30301

Human Synonyms: AQP0, CTRCT15, LIM1, MIP26, MP26

Human Chr (Location): 12q13; chr12:56449502-56456553 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MIP

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(21) Radiation induced(1) Spontaneous(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes have microphthalmia and lens opacity. Other defects may include degeneration of lens fiber cells, vacuolization of lens fibers and reduced gamma:alpha crystallin ratio. Heterozygotes have less severe forms of lens cataract and microphthalmia.
 
Human Diseases Modeled in Mice Using Mip (1)    Mutations Annotated to Human Diseases (5)   
Interactions
Mip interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process canalicular bile acid transport, carbohydrate transmembrane transport, ...
Component apical plasma membrane, cell junction, ...
Function channel activity, glycerol channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (92)    Tissues (77)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
Western blot 5
RT-PCR 58
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mip ; ZFIN mipa, mipb    NEW 
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024337 (Evidence)
Ensembl Gene Model ENSMUSG00000025389 (Evidence)
Entrez Gene 17339 (Evidence)
DFCI TC1582418
DoTS DT.110625752, DT.40157474
Consensus CDS Project CCDS24265.1
International Mouse Phenotyping Consortium Status Mip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024337 VEGA Gene Model | MGI Sequence Detail 5975 C57BL/6J ±  kb
transcript OTTMUST00000059620 VEGA | MGI Sequence Detail 2144 Not Applicable 
polypeptide OTTMUSP00000029013 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000010911 lens fiber major intrinsic protein
References
(Earliest) J:285 PAGET OE, [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse.]. Z Indukt Abstamm Vererbungsl. 1953;85(2):238-44
(Latest) J:220085 Kumari SS, et al., Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration. Biochem Biophys Res Commun. 2014 Oct 3;452(4):986-91
All references(104)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-10701, MGD-MRK-11842, MGD-MRK-12240, MGD-MRK-14658, MGD-MRK-1767, MGD-MRK-2244, MGI:88560, MGI:96076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory