Mip
Gene Detail

Symbol Name ID

Mip major intrinsic protein of eye lens fiber MGI:96990

Synonyms

Aqp0, aquaporin 0, lens opacity, Lop, MIP26, shrivelled, Svl

Feature Type

protein coding gene

Genetic Map

Chromosome 10

76.49 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr10:128225838-128231812 bp, + strand From VEGA annotation of GRCm38   5975 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40627  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Mip

Human homologs

Human Homolog		MIP, major intrinsic protein of lens fiber
NCBI Gene ID		4284
neXtProt AC		NX_P30301
Human Synonyms		AQP0, LIM1, MIP26, MP26
Human Chr (Location)		12q13; chr12:56843286-56848435 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MIP

Alleles and phenotypes

All alleles(29) : Targeted(2) Gene trapped(21) Spontaneous(5) Radiation induced(1)
 

Homozygotes have microphthalmia and lens opacity. Other defects may include degeneration of lens fiber cells, vacuolization of lens fibers and reduced gamma:alpha crystallin ratio. Heterozygotes have less severe forms of lens cataract and microphthalmia.

 
Human Diseases Modeled Using Mouse Mip (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	canalicular bile acid transport, cell communication, ...
Component	cell junction, gap junction, ...
Function	channel activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (50)    Tissues (48)    Images (6)
Theiler Stages: 21, 23, 24, 28

Assay Type	Results
Immunohistochemistry	4
RT-PCR	46

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024337 (Evidence)
Ensembl Gene Model	ENSMUSG00000025389 (Evidence)
Entrez Gene	17339 (Evidence)
DFCI	TC1582418
DoTS	DT.110625752, DT.40157474
Consensus CDS Project	CCDS24265.1
International Mouse Knockout Project Status	Mip

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024337	VEGA Gene Model | MGI Sequence Detail	5975	C57BL/6J
transcript	OTTMUST00000059620	VEGA | MGI Sequence Detail	2144	Not Applicable
polypeptide	OTTMUSP00000029013	VEGA | MGI Sequence Detail	263	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023271	Aquaporin-like
InterPro	IPR000425	Major intrinsic protein
InterPro	IPR022357	Major intrinsic protein, conserved site
Protein Ontology	PR:000010911	lens fiber major intrinsic protein

References

(Earliest) J:285 PAGET OE, [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse.]. Z Indukt Abstamm Vererbungsl. 1953;85(2):238-44
(Latest) J:189960 Madakashira BP, et al., Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 2012 Dec;139(24):4601-12
All references(93)

Other accession IDs

MGD-MRK-10701, MGD-MRK-11842, MGD-MRK-12240, MGD-MRK-14658, MGD-MRK-1767, MGI:96076