About   Help   FAQ
Met Gene Detail
Summary
  • Symbol
    Met
  • Name
    met proto-oncogene
  • Synonyms
    c-Met, HGF receptor, Par4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96969
    NCBI Gene: 17295
  • Gene Overview
    MyGene.info: MET
Location & Maps
more
  • Sequence Map
    Chr6:17463800-17573980 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110181 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 7.83 cM, cytoband A2
  • Mapping Data
    48 experiments
Homology
more
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    AUTS9, c-Met, DFNB97, HGFR, RCCP2
  • Links
    NCBI Gene ID: 4233
    neXtProt AC: NX_P08581

  • Chr Location
    7q31; chr7:116672405-116798386 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Met mouse models; 2 with human MET associations

Human Disease Mouse Models
       Autism, Susceptibility to, 9; AUTS9   OMIM: 611015 View 1 model
Breast Cancer   OMIM: 114480 View 1 model
Gilles De La Tourette Syndrome; GTS   OMIM: 137580 View 1 model
       Hepatocellular Carcinoma   OMIM: 114550 View 1 model
Renal Cell Carcinoma, Papillary, 1; RCCP1   OMIM: 605074
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    93 phenotypes from 21 alleles in 18 genetic backgrounds
    24 phenotypes from multigenic genotypes
    1 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • QTL
    1
  • Targeted
    23
  • Transgenic
    3
  • Genomic Mutations
    1 involving Met
  • Incidental Mutations
Homozygous null mutants exhibit impaired embryonic development resulting in death. Abnormalities observed in various mutant lines include muscle agenesis due to impaired migration of myogenic precursors, defects of motor axon migration, and placental andliver defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024024 VEGA Gene Model | MGI Sequence Detail 110181 C57BL/6J ±  kb
transcript OTTMUST00000058743 VEGA | MGI Sequence Detail 4663 Not Applicable  
polypeptide OTTMUSP00000028499 VEGA | MGI Sequence Detail 1379 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1460 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 112
    Genomic 14
    cDNA 86
    Primer pair 8
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-12203, MGI:1197520, MGI:2141478
References
more
  • Summaries
    All 238
    Developmental Gene Expression 85
    Diseases 4
    Gene Ontology 20
    Phenotypes 78
  • Earliest
    J:8287 Park M, et al., Mechanism of met oncogene activation. Cell. 1986 Jun 20;45(6):895-904
  • Latest
    J:231751 Lo FS, et al., Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met Activity. J Neurosci. 2016 Mar 30;36(13):3691-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory