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Met Gene Detail
Summary
  • Symbol
    Met
  • Name
    met proto-oncogene
  • Synonyms
    c-Met, HGF receptor, Par4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96969
    NCBI Gene: 17295
  • Gene Overview
    MyGene.info: MET
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:17463800-17573980 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 7.83 cM, cytoband A2
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1460 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96969
protein coding gene Chr6:17463348-17573980 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030470
protein coding gene Chr6:14711251-14826916 (+)
A/J MGP_AJ_G0030443
protein coding gene Chr6:14114561-14223873 (+)
AKR/J MGP_AKRJ_G0030370
protein coding gene Chr6:14609364-14719673 (+)
BALB/cJ MGP_BALBcJ_G0030452
protein coding gene Chr6:14201413-14310538 (+)
C3H/HeJ MGP_C3HHeJ_G0030166
protein coding gene Chr6:14475187-14586969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030907
protein coding gene Chr6:15165870-15287061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028118
protein coding gene Chr6:13078802-13187922 (+)
CAST/EiJ MGP_CASTEiJ_G0029568
protein coding gene Chr6:14371859-14489616 (+)
CBA/J MGP_CBAJ_G0030144
protein coding gene Chr6:15661669-15787158 (+)
DBA/2J MGP_DBA2J_G0030288
protein coding gene Chr6:14038682-14156914 (+)
FVB/NJ MGP_FVBNJ_G0030242
protein coding gene Chr6:13881162-13992183 (+)
LP/J MGP_LPJ_G0030375
protein coding gene Chr6:14787654-14908342 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030278
protein coding gene Chr6:16848367-16963869 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030937
protein coding gene Chr6:14485053-14600551 (+)
PWK/PhJ MGP_PWKPhJ_G0029282
protein coding gene Chr6:13688603-13800808 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029118
protein coding gene Chr6:14363875-14478353 (+)
WSB/EiJ MGP_WSBEiJ_G0029644
protein coding gene Chr6:14428737-14543450 (+)



Homology
more
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AUTS9, c-Met, DFNB97, HGFR, RCCP2
  • Links
    NCBI Gene ID: 4233
    neXtProt AC: NX_P08581
    UniProt: P08581

  • Chr Location
    7q31.2; chr7:116672359-116798386 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Met mouse models; 3 with human MET associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    98 phenotypes from 21 alleles in 19 genetic backgrounds
    24 phenotypes from multigenic genotypes
    1 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired embryonic development resulting in death. Abnormalities observed in various mutant lines include muscle agenesis due to impaired migration of myogenic precursors, defects of motor axon migration, and placental andliver defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009376 Ensembl Gene Model | MGI Sequence Detail 110181 C57BL/6J ±  kb
    transcript ENSMUST00000115443 Ensembl | MGI Sequence Detail 6809 Not Applicable  
    polypeptide ENSMUSP00000111103 Ensembl | MGI Sequence Detail 1379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 14
      cDNA 88
      Primer pair 8
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12203, MGI:1197520, MGI:2141478
    References
    more
    • Summaries
      All 298
      Developmental Gene Expression 96
      Diseases 4
      Gene Ontology 21
      Phenotypes 86
    • Earliest
      J:8287 Park M, et al., Mechanism of met oncogene activation. Cell. 1986 Jun 20;45(6):895-904
    • Latest
      J:264385 Sefton EM, et al., Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle. Dev Biol. 2018 Aug 15;440(2):64-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory