About   Help   FAQ
Met
Gene Detail
Symbol

Name
ID
Met
met proto-oncogene
MGI:96969
Synonyms
c-Met, HGF receptor, Par4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
7.83 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(48)
Sequence Map
Chr6:17463800-17573980 bp, + strand
From VEGA annotation of GRCm38

  110181 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:206  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, HGF/MSP receptor type
Gene Tree: Met

Human
homologs
Human Homolog MET, MET proto-oncogene, receptor tyrosine kinase
NCBI Gene ID 4233
neXtProt AC  NX_P08581
Human Synonyms  AUTS9, c-Met, HGFR, RCCP2
Human Chr (Location)  7q31; chr7:116672357-116798386 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MET
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : QTL(1) Targeted(22)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit impaired embryonic development resulting in death. Abnormalities observed in various mutant lines include muscle agenesis due to impaired migration of myogenic precursors, defects of motor axon migration, and placental and liver defects.
 
Human Diseases Modeled Using Mouse Met (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Met interacts with 337 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process activation of MAPK activity, adult behavior, ...
Component basal plasma membrane, cell surface, ...
Function ATP binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (301)    Tissues (178)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 231
Northern blot 18
RT-PCR 47
cDNA source data(82)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(14) cDNA(84) Primer pair(6) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024024 (Evidence)
Ensembl Gene ModelENSMUSG00000009376 (Evidence)
Entrez Gene17295 (Evidence)
UniGene86844
DFCITC1603243, TC1623772, TC1695814
DoTSDT.87048892, DT.97344759
NIA Mouse Gene IndexU042722
EC2.7.10.1
Consensus CDS ProjectCCDS19925.1
International Mouse Knockout Project StatusMet
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024024 VEGA Gene Model | MGI Sequence Detail 110181 C57BL/6J ±  kb
transcript OTTMUST00000058743 VEGA | MGI Sequence Detail 4663 Not Applicable 
polypeptide OTTMUSP00000028499 VEGA | MGI Sequence Detail 1379 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(4) UniProt(19)
Polymorphisms
RFLP(13) : SNPs within 2kb(1463 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000010335 hepatocyte growth factor receptor
References
(Earliest) J:8287 Park M, et al., Mechanism of met oncogene activation. Cell. 1986 Jun 20;45(6):895-904
(Latest) J:214127 Koraishy FM, et al., Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. J Biol Chem. 2014 May 16;289(20):14341-50
All references(229)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12203, MGI:1197520, MGI:2141478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory