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Mdm2 Gene Detail
Summary
  • Symbol
    Mdm2
  • Name
    transformed mouse 3T3 cell double minute 2
  • Synonyms
    1700007J15Rik, Mdm-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96952
    NCBI Gene: 17246
  • Alliance
  • Transcription Start Sites
    21 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:117524780-117546663 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.32 cM, cytoband C1-C3
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96952
protein coding gene Chr10:117524780-117546663 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017761
protein coding gene Chr10:120636918-120662030 (-)
A/J MGP_AJ_G0017737
protein coding gene Chr10:115909004-115931632 (-)
AKR/J MGP_AKRJ_G0017699
protein coding gene Chr10:119314449-119337350 (-)
BALB/cJ MGP_BALBcJ_G0017700
protein coding gene Chr10:116306890-116332248 (-)
C3H/HeJ MGP_C3HHeJ_G0017525
protein coding gene Chr10:119535199-119557492 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018155
protein coding gene Chr10:124786893-124808453 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015836
protein coding gene Chr10:110481727-110503005 (-)
CAST/EiJ MGP_CASTEiJ_G0017085
protein coding gene Chr10:119841316-119865319 (-)
CBA/J MGP_CBAJ_G0017494
protein coding gene Chr10:129723249-129749292 (-)
DBA/2J MGP_DBA2J_G0017599
protein coding gene Chr10:115057637-115080692 (-)
FVB/NJ MGP_FVBNJ_G0017594
protein coding gene Chr10:114022510-114045586 (-)
LP/J MGP_LPJ_G0017672
protein coding gene Chr10:121181891-121207093 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017623
protein coding gene Chr10:132534248-132560281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018195
protein coding gene Chr10:119382259-119403777 (-)
PWK/PhJ MGP_PWKPhJ_G0016869
protein coding gene Chr10:115154437-115178073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016659
protein coding gene Chr10:118160014-118186787 (-)
WSB/EiJ MGP_WSBEiJ_G0017147
protein coding gene Chr10:119569983-119591545 (-)



Homology
more
  • Human Ortholog
    MDM2, MDM2 proto-oncogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MDM2, MDM2 proto-oncogene
  • Synonyms
    ACTFS, hdm2, HDMX, LSKB
  • Links
    NCBI Gene ID: 4193
    neXtProt AC: NX_Q00987
    UniProt: Q00987

  • Chr Location
    12q15; chr12:68808172-68850686 (+)  GRCh38

Human Diseases
more
  • Diseases
    5 with human MDM2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 14 alleles in 11 genetic backgrounds
    79 phenotypes from multigenic genotypes
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality. Mice homozygous for a null allele exhibit prenatal lethality.Mice homozygous for one knock-in allele exhibit embryonic lethality while mice homozygous for a different knock-in allele exhibit altered cell cycle regulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17246 NCBI Gene Model | MGI Sequence Detail 21884 C57BL/6J ±  kb
    transcript NM_010786 RefSeq | MGI Sequence Detail 3124 Not Specified  
    polypeptide P23804 UniProt | EBI | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 17
      cDNA 29
      Primer pair 10
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12169, MGD-MRK-12172, MGI:1916580, MGI:2143477
    References
    more
    • Summaries
      All 407
      Developmental Gene Expression 64
      Gene Ontology 42
      Phenotypes 159
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:339368 Yao F, et al., Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Cell Death Dis. 2023 Aug 23;14(8):543

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory