Mdm2
Gene Detail

Symbol Name ID

Mdm2 transformed mouse 3T3 cell double minute 2 MGI:96952

Synonyms

1700007J15Rik, Mdm-2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

66.32 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr10:117688888-117710758 bp, - strand From VEGA annotation of GRCm38   21871 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; horse    (Mammalian Orthology)
Comparative Map (Mouse/Human Mdm2 ± 2 cM)

Protein SuperFamily: p53 negative regulator Mdm2/Mdm4
Gene Tree: Mdm2

Human ortholog

MDM2 MDM2 oncogene, E3 ubiquitin protein ligase NCBI Gene ID 4193
Human Synonyms: ACTFS, hdm2, HDMX
Human Chr12:69201971-69239212 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human MDM2 (1)

Alleles and phenotypes

All alleles(70) : Targeted(19) Gene trapped(51)
 

Mice homozygous for a gene trapped allele exhibit embryonic lethality. Mice homozygous for a null allele exhibit prenatal lethality. Mice homozygous for one knock-in allele exhibit embryonic lethality while mice homozygous for a different knock-in allele exhibit alters cell cycle regulation.

 

Gene Ontology (GO) classifications

All GO classifications: (62 annotations)

Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, establishment of protein localization, ...
Component	cytoplasm, cytosol, ...
Function	enzyme binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (190)    Tissues (118)    Images (31)
Theiler Stages: 1, 2, 3, 4, 11, 12, 13, 14, 17, 18, 19, 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	87
Northern blot	26
Western blot	14
RT-PCR	46

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(17) cDNA(25) Primer pair(1) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020921 (Evidence)
Ensembl Gene Model	ENSMUSG00000020184 (Evidence)
Entrez Gene	17246 (Evidence)
DFCI	TC1572732, TC1594843, TC1614698
DoTS	DT.55101146, DT.94348468, DT.94348478, DT.97334051
NIA Mouse Gene Index	U162215
EC	6.3.2.-
Consensus CDS Project	CCDS24194.1
International Mouse Knockout Project Status	Mdm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020921	VEGA Gene Model | MGI Sequence Detail	21871	C57BL/6J
transcript	OTTMUST00000049452	VEGA | MGI Sequence Detail	3086	Not Applicable
polypeptide	OTTMUSP00000022916	VEGA | MGI Sequence Detail	489	Not Applicable

All sequences(75) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(88 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016495	p53 negative regulator Mdm2/Mdm4
InterPro	IPR003121	SWIB/MDM2 domain
InterPro	IPR001876	Zinc finger, RanBP2-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000010267	E3 ubiquitin-protein ligase Mdm2

References

(Earliest) J:8787 Cahilly-Snyder L, et al., Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat Cell Mol Genet. 1987 May;13(3):235-44
(Latest) J:192387 Roudier E, et al., Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB J. 2012 Nov;26(11):4530-9
All references(221)

Other accession IDs

MGD-MRK-12169, MGD-MRK-12172, MGI:1916580, MGI:2143477