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Gene Detail
transformed mouse 3T3 cell double minute 2
Synonyms 1700007J15Rik, Mdm-2
Feature Type protein coding gene
Genetic Map
Chromosome 10
66.32 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM

Mapping data(9)
Sequence Map
Chr10:117688888-117710758 bp, - strand
From VEGA annotation of GRCm38

  21871 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:1793  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: p53 negative regulator Mdm2/Mdm4
Gene Tree: Mdm2

Human Homolog MDM2, MDM2 proto-oncogene, E3 ubiquitin protein ligase
NCBI Gene ID 4193
neXtProt AC  NX_Q00987
Human Synonyms  ACTFS, hdm2, HDMX
Human Chr (Location)  12q14.3-q15; chr12:68808172-68845544 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MDM2
alleles, and
All mutations/alleles(70) : Gene trapped(51) Targeted(19)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a gene trapped allele exhibit embryonic lethality. Mice homozygous for a null allele exhibit prenatal lethality. Mice homozygous for one knock-in allele exhibit embryonic lethality while mice homozygous for a different knock-in allele exhibit alters cell cycle regulation.
Mdm2 interacts with 260 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (78 annotations)
Process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, establishment of protein localization, ...
Component cytoplasm, cytosol, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Literature Summary: (32 records)
Data Summary: Results (181)    Tissues (119)    Images (31)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 14, 17, 18, 19, 20, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 87
Northern blot 17
Western blot 14
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(46) Genomic(17) cDNA(26) Primer pair(1) Other(2)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000020921 (Evidence)
Ensembl Gene ModelENSMUSG00000020184 (Evidence)
Entrez Gene17246 (Evidence)
DFCITC1572732, TC1594843, TC1614698, TC1649594
DoTSDT.55101146, DT.94348468, DT.94348474, DT.94348478, DT.97334051
NIA Mouse Gene IndexU162215
Consensus CDS ProjectCCDS24194.1, CCDS70110.1
International Mouse Knockout Project StatusMdm2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020921 VEGA Gene Model | MGI Sequence Detail 21871 C57BL/6J ±  kb
transcript OTTMUST00000049452 VEGA | MGI Sequence Detail 3086 Not Applicable 
polypeptide OTTMUSP00000022916 VEGA | MGI Sequence Detail 489 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(6) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(194 from dbSNP Build 137)
InterPro IPR016495 p53 negative regulator Mdm2/Mdm4
InterPro IPR003121 SWIB/MDM2 domain
InterPro IPR015459 Ubiquitin-protein ligase E3 MDM2
InterPro IPR001876 Zinc finger, RanBP2-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000010267 E3 ubiquitin-protein ligase Mdm2
References (Earliest) J:8787 Cahilly-Snyder L, et al., Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat Cell Mol Genet. 1987 May;13(3):235-44
(Latest) J:211903 Frum RA, et al., The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing. Nucleic Acids Res. 2014 Jan;42(2):926-40
All references(235)
accession IDs
MGD-MRK-12169, MGD-MRK-12172, MGI:1916580, MGI:2143477

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory