68 phenotypes from 15 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mdm2Gt(Ex65)Byg/Mdm2Gt(Ex65)Byg involves: 129P2/OlaHsd * C57BL/6	embryonic lethality, complete penetrance	J:70273
Mdm2tm1.1Mep/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6	prenatal lethality, complete penetrance	J:81065
Mdm2tm1.1Ypz/Mdm2tm1.1Ypz B6.129-Mdm2tm1.1Ypz	increased cell proliferation	J:164200
Mdm2tm1Bay/Mdm2+ B6.129S7-Mdm2tm1Bay	increased mortality induced by gamma-irradiation	J:81065
Mdm2tm1Bay/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6 * FVB	prenatal lethality, complete penetrance	J:81065
Mdm2tm1Bay/Mdm2tm1.2Mep involves: 129S7/SvEvBrd * C57BL/6 * FVB	no abnormal phenotype detected	J:81065
Mdm2tm1Bay/Mdm2tm1Bay involves: 129S7/SvEvBrd	abnormal embryonic tissue morphology	J:29811
	embryonic lethality between implantation and somite formation, complete penetrance	J:29811
Mdm2tm1Bay/Mdm2tm1Mep involves: 129S7/SvEvBrd * C57BL/6	abnormal B cell differentiation	J:81065
	abnormal cell cycle checkpoint function	J:81065
	anemia	J:81065
	decreased body weight	J:81065
	decreased bone marrow cell number	J:81065
	decreased cell proliferation	J:81065
	decreased double-negative T cell number	J:81065
	decreased double-positive T cell number	J:81065
	decreased erythrocyte cell number	J:81065
	decreased granulocyte number	J:81065
	decreased immature B cell number	J:81065
	decreased kidney weight	J:81065
	decreased leukocyte cell number	J:81065
	decreased liver weight	J:81065
	decreased lymphocyte cell number	J:81065
	decreased neutrophil cell number	J:81065
	decreased spleen weight	J:81065
	decreased T cell number	J:81065
	decreased thymocyte number	J:81065
	decreased thymus weight	J:81065
	increased cellular sensitivity to ionizing radiation	J:81065
	prenatal lethality, incomplete penetrance	J:81065
	spleen hypoplasia	J:81065
	thymus hypoplasia	J:81065
Mdm2tm1Glo/Mdm2+ involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	abnormal cell physiology	J:123661
	increased mortality induced by ionizing radiation	J:123661
Mdm2tm1Glo/Mdm2+ involves: 129S7/SvEvBrd	increased foot pad pigmentation	J:174216
Mdm2tm1Glo/Mdm2tm1Glo involves: 129S7/SvEvBrd	abnormal hematopoietic system physiology	J:158953
Mdm2tm1Glo/Mdm2tm1Glo involves: 129S7/SvEvBrd * C57BL/6J	abnormal embryonic tissue morphology	J:29810
	embryonic lethality between implantation and somite formation, complete penetrance	J:29810
	empty decidua capsularis	J:29810
Mdm2tm1Glo/Mdm2tm2.1Glo involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:75118
Mdm2tm1Glo/Mdm2tm2.1Glo Tg(Myh6-cre)2182Mds/0 involves: 129S7/SvEvBrd * FVB/N	abnormal blood circulation	J:104114
	abnormal cardiovascular system physiology	J:104114
	abnormal heart morphology	J:104114
	abnormal heart ventricle morphology	J:104114
	decreased embryo size	J:104114
	embryonic lethality during organogenesis, complete penetrance	J:104114
	hemorrhage	J:104114
	increased cardiomyocyte apoptosis	J:104114
	small heart	J:104114
	thin myocardium	J:104114
Mdm2tm1Glo/Mdm2tm2Glo involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:75118
Mdm2tm1Mep/Mdm2+ involves: 129S7/SvEvBrd * C57BL/6	increased mortality induced by gamma-irradiation	J:81065
Mdm2tm1Mep/Mdm2tm1.1Mep involves: 129S7/SvEvBrd * C57BL/6 * FVB	decreased body weight	J:81065
	decreased kidney weight	J:81065
	decreased liver weight	J:81065
	decreased spleen weight	J:81065
	decreased thymus weight	J:81065
Mdm2tm1Mep/Mdm2tm1Mep involves: 129S7/SvEvBrd * C57BL/6	normal growth/size/body region phenotype	J:81065
Mdm2tm1Snj/Mdm2tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:75119
Mdm2tm1Snj/Mdm2tm1Snj involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:75119
Mdm2tm1Ypz/Mdm2tm1Ypz involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	abnormal gastrulation	J:126004
	decreased embryo size	J:126004
	embryonic growth retardation	J:126004
	embryonic lethality between implantation and somite formation, complete penetrance	J:126004
Mdm2tm2.1Glo/Mdm2tm2.1Glo involves: 129S7/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:75118
Mdm2tm2.1Snj/Mdm2tm2.1Snj involves: 129S4/SvJae * C57BL/6	abnormal cell cycle	J:189297
	abnormal kidney morphology	J:189297
	abnormal liver morphology	J:189297
	decreased apoptosis	J:189297
	decreased mortality induced by ionizing radiation	J:189297
	decreased thymocyte apoptosis	J:189297
	enlarged spleen	J:189297
	increased B cell derived lymphoma incidence	J:189297
	increased T cell derived lymphoma incidence	J:189297
	increased tumor incidence	J:189297
Mdm2tm2.3Glo/Mdm2tm2.3Glo involves: 129S7/SvEvBrd * C57BL/6J	prenatal lethality, complete penetrance	J:75118
Mdm2tm3.1Snj/Mdm2tm3.1Snj involves: 129S4/SvJae * C57BL/6	normal cellular phenotype	J:189297
	normal immune system phenotype	J:189297
	increased salivary gland tumor incidence	J:189297
Tg(Mdm2)1Snj/0 involves: 129S7/SvEvBrd * C57BL/6	increased adenocarcinoma incidence	J:51661
	increased hemangiosarcoma incidence	J:51661
	increased lymphoma incidence	J:51661
	increased pituitary adenoma incidence	J:51661
	increased rhabdomyosarcoma incidence	J:51661
	increased sarcoma incidence	J:51661
	increased tumor incidence	J:51661
Tg(Mdm2)1Snj/Tg(Mdm2)1Snj involves: 129S7/SvEvBrd * C57BL/6	increased tumor incidence	J:51661