Tg(Mdm2)1Snj
Transgene Detail

Summary

• Symbol: Tg(Mdm2)1Snj
• Name: transgene insertion 1, Stephen N Jones
• MGI ID: MGI:2182249
• Synonyms: Mdm2^Tg
• Transgene: Tg(Mdm2)1Snj Location: unknown
• Alliance: Tg(Mdm2)1Snj page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:51661
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mdm2)1Snj expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mdm2 (MGI:96952)

• Mutation details: The entire Mdm2 gene was used as the transgene. The transgene is under the control of the native promoter. (J:51661)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Mdm2)1Snj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic animals express 4 times the amount of endogenous mRNA transcripts and exhibit and increased incidence of spontaneous tumorigenesis. Susceptibility to tumor formation appears to be influenced by gene dosage. One half of hemizogous transgenic animals succumb to neoplasia by 84 weeks of age compared to 61 weeks for homozygous transgenic animals.

References

• Original: J:51661 Jones SN, et al., Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15608-12
• All: 10 reference(s)