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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mdm2)1Snj
transgene insertion 1, Stephen N Jones
MGI:2182249
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Mdm2)1Snj/0
Trp53tm1Brd/Trp53tm1Brd 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5604449
tg2
 		Tg(Mdm2)1Snj/Tg(Mdm2)1Snj involves: 129S7/SvEvBrd * C57BL/6 MGI:5604448
tg3
 		Tg(Mdm2)1Snj/0 involves: 129S7/SvEvBrd * C57BL/6 MGI:5604446


Genotype
MGI:5604449
cx1
Allelic
Composition		 Tg(Mdm2)1Snj/0
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mdm2)1Snj mutation (0 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:51661 )
• 67% of mice develop lymphoma
• 14 of 26 tumors are malignant lymphoma
increased medulloblastoma incidence ( J:51661 )
• 1 of 16 tumors is a medulloblastoma
increased squamous cell carcinoma incidence ( J:51661 )
• 1 of 16 tumors is a squamous cell carcinoma
increased hemangiosarcoma incidence ( J:51661 )
• 8 of 26 tumors are hemangiosarcomas
increased osteosarcoma incidence ( J:51661 )
• 2 of 16 tumors are osteosarcomas

skeleton
increased osteosarcoma incidence ( J:51661 )
• 2 of 16 tumors are osteosarcomas

nervous system
increased medulloblastoma incidence ( J:51661 )
• 1 of 16 tumors is a medulloblastoma




Genotype
MGI:5604448
tg2
Allelic
Composition		 Tg(Mdm2)1Snj/Tg(Mdm2)1Snj
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:51661 )
• 50% of mice develop neoplasia by 61 weeks of age




Genotype
MGI:5604446
tg3
Allelic
Composition		 Tg(Mdm2)1Snj/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:51661 )
• 50% of mice succumb to neoplasia by 84 weeks of age
increased pituitary adenoma incidence ( J:51661 )
• 1 of 16 tumors are pituitary adenomas
increased lymphoma incidence ( J:51661 )
• 64% tumors are malignant lymphoma
increased adenocarcinoma incidence ( J:51661 )
• 1 of 16 tumors are adenocarcinomas
increased sarcoma incidence ( J:51661 )
• 38% of all tumors seen in mice are sarcomas
increased rhabdomyosarcoma incidence ( J:51661 )
• 1 of 16 tumors are rhabdomyosarcomas
increased hemangiosarcoma incidence ( J:51661 )
• 9 of 26 tumors are hemangiosarcomas

endocrine/exocrine glands
increased pituitary adenoma incidence ( J:51661 )
• 1 of 16 tumors are pituitary adenomas

muscle
increased rhabdomyosarcoma incidence ( J:51661 )
• 1 of 16 tumors are rhabdomyosarcomas

nervous system
increased pituitary adenoma incidence ( J:51661 )
• 1 of 16 tumors are pituitary adenomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory