Phenotypes associated with this allele

• Allele Symbol: Tg(Mdm2)1Snj
• Allele Name: transgene insertion 1, Stephen N Jones
• Allele ID: MGI:2182249
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Mdm2)1Snj/0 Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6	MGI:5604449
tg2	Tg(Mdm2)1Snj/Tg(Mdm2)1Snj	involves: 129S7/SvEvBrd * C57BL/6	MGI:5604448
tg3	Tg(Mdm2)1Snj/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:5604446

Genotype
MGI:5604449

cx1

• Allelic Composition: Tg(Mdm2)1Snj/0; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lymphoma incidence ( J:51661 )

• 67% of mice develop lymphoma

• 14 of 26 tumors are malignant lymphoma

increased medulloblastoma incidence ( J:51661 )

• 1 of 16 tumors is a medulloblastoma

increased squamous cell carcinoma incidence ( J:51661 )

• 1 of 16 tumors is a squamous cell carcinoma

increased hemangiosarcoma incidence ( J:51661 )

• 8 of 26 tumors are hemangiosarcomas

increased osteosarcoma incidence ( J:51661 )

• 2 of 16 tumors are osteosarcomas

skeleton

increased osteosarcoma incidence ( J:51661 )

• 2 of 16 tumors are osteosarcomas

nervous system

increased medulloblastoma incidence ( J:51661 )

• 1 of 16 tumors is a medulloblastoma

Genotype
MGI:5604448

tg2

• Allelic Composition: Tg(Mdm2)1Snj/Tg(Mdm2)1Snj
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

neoplasm

increased tumor incidence ( J:51661 )

• 50% of mice develop neoplasia by 61 weeks of age

Genotype
MGI:5604446

tg3

• Allelic Composition: Tg(Mdm2)1Snj/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

neoplasm

increased tumor incidence ( J:51661 )

• 50% of mice succumb to neoplasia by 84 weeks of age

increased pituitary adenoma incidence ( J:51661 )

• 1 of 16 tumors are pituitary adenomas

increased lymphoma incidence ( J:51661 )

• 64% tumors are malignant lymphoma

increased adenocarcinoma incidence ( J:51661 )

• 1 of 16 tumors are adenocarcinomas

increased sarcoma incidence ( J:51661 )

• 38% of all tumors seen in mice are sarcomas

increased rhabdomyosarcoma incidence ( J:51661 )

• 1 of 16 tumors are rhabdomyosarcomas

increased hemangiosarcoma incidence ( J:51661 )

• 9 of 26 tumors are hemangiosarcomas

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:51661 )

• 1 of 16 tumors are pituitary adenomas

muscle

increased rhabdomyosarcoma incidence ( J:51661 )

• 1 of 16 tumors are rhabdomyosarcomas

nervous system

increased pituitary adenoma incidence ( J:51661 )

• 1 of 16 tumors are pituitary adenomas