Mc3r
Gene Detail

Symbol Name ID

Mc3r melanocortin 3 receptor MGI:96929

Feature Type

protein coding gene

Genetic Map

Chromosome 2

94.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr2:172248492-172251114 bp, + strand From VEGA annotation of GRCm38   2623 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc3r

Human homologs

Human Homolog		MC3R, melanocortin 3 receptor
NCBI Gene ID		4159
neXtProt AC		NX_P41968
Human Synonyms		BMIQ9, MC3, MC3-R, OB20, OQTL
Human Chr (Location)		20q13.2-q13.3; chr20:54823788-54824871 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MC3R

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for a null allele exhibit obesity, increased respiratory quotient on a high fat diet, and reduced energy expenditure. Homozygotes for another null allele show reduced lean mass, increased fat mass, diet-induced obesity, increased insulin and leptin levels, and reduced energy expenditure.

 
Human Diseases Modeled Using Mouse Mc3r (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, melanocortin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	29

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(3) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016156 (Evidence)
Ensembl Gene Model	ENSMUSG00000038537 (Evidence)
Entrez Gene	17201 (Evidence)
UniGene	57183
DFCI	TC1590696
DoTS	DT.91587478
NIA Mouse Gene Index	U002896
Consensus CDS Project	CCDS17127.1
International Mouse Knockout Project Status	Mc3r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016156	VEGA Gene Model | MGI Sequence Detail	2623	C57BL/6J
transcript	OTTMUST00000038653	VEGA | MGI Sequence Detail	2623	Not Applicable
polypeptide	OTTMUSP00000017290	VEGA | MGI Sequence Detail	323	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR002122	Melanocortin 3 receptor
InterPro	IPR001671	Melanocortin/ACTH receptor
InterPro	IPR001908	Melanocortin receptor
Protein Ontology	PR:000001236	melanocortin receptor 3

References

(Earliest) J:17785 Desarnaud F, et al., Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem J. 1994 Apr 15;299(Pt 2):367-73
(Latest) J:195073 Arteaga-Solis E, et al., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8;17(1):35-48
All references(69)

Other accession IDs

MGD-MRK-12131