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Mc3r
Gene Detail
Symbol

Name
ID
Mc3r
melanocortin 3 receptor
MGI:96929
Feature Type
protein coding gene
Genetic Map
Chromosome 2
94.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:172248492-172251114 bp, + strand
From VEGA annotation of GRCm38

  2623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MC3R
Protein SuperFamily: melanocortin receptor
Gene Tree: Mc3r

Human
homologs
MC3R, melanocortin 3 receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4159
neXtProt AC: NX_P41968

Human Synonyms: BMIQ9, MC3, MC3-R, OB20, OQTL

Human Chr (Location): 20q13.2-q13.3; chr20:56248732-56249815 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MC3R

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele exhibit obesity, increased respiratory quotient on a high fat diet, and reduced energy expenditure. Homozygotes for another null allele show reduced lean mass, increased fat mass, diet-induced obesity, increased insulin and leptin levels, and reduced energy expenditure.
 
Human Diseases Modeled in Mice Using Mc3r (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Mc3r interacts with 147 markers (Mir15a, Mir15b, Mir16-1, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (29)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mc3r ; ZFIN mc3r    NEW 
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016156 (Evidence)
Ensembl Gene Model ENSMUSG00000038537 (Evidence)
Entrez Gene 17201 (Evidence)
UniGene 57183
DFCI TC1590696
DoTS DT.91587478
NIA Mouse Gene Index U002896
Consensus CDS Project CCDS17127.1
International Mouse Phenotyping Consortium Status Mc3r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016156 VEGA Gene Model | MGI Sequence Detail 2623 C57BL/6J ±  kb
transcript OTTMUST00000038653 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000017290 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002122 Melanocortin 3 receptor
InterPro IPR001671 Melanocortin/ACTH receptor
InterPro IPR001908 Melanocortin receptor
Protein Ontology PR:000001236 melanocortin receptor 3
References
(Earliest) J:17785 Desarnaud F, et al., Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem J. 1994 Apr 15;299(Pt 2):367-73
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory