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Mc3r
Gene Detail
 Symbol
Name
ID
Mc3r
melanocortin 3 receptor
MGI:96929
Feature Type protein coding gene
Genetic Map
Chromosome 2
94.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:172248492-172251114 bp, + strand
From VEGA annotation of GRCm38

  2623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc3r

Human
homologs
Human Homolog MC3R, melanocortin 3 receptor
NCBI Gene ID 4159
neXtProt AC  NX_P41968
Human Synonyms  BMIQ9, MC3, MC3-R, OB20, OQTL
Human Chr (Location)  20q13.2-q13.3; chr20:56248732-56249815 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MC3R
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele exhibit obesity, increased respiratory quotient on a high fat diet, and reduced energy expenditure. Homozygotes for another null allele show reduced lean mass, increased fat mass, diet-induced obesity, increased insulin and leptin levels, and reduced energy expenditure.
 
Human Diseases Modeled Using Mouse Mc3r (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process adenylate cyclase-modulating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, melanocortin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 29
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016156 (Evidence)
Ensembl Gene ModelENSMUSG00000038537 (Evidence)
Entrez Gene17201 (Evidence)
UniGene57183
DFCITC1590696
DoTSDT.91587478
NIA Mouse Gene IndexU002896
Consensus CDS ProjectCCDS17127.1
International Mouse Knockout Project StatusMc3r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016156 VEGA Gene Model | MGI Sequence Detail 2623 C57BL/6J ±  kb
transcript OTTMUST00000038653 VEGA | MGI Sequence Detail 2623 Not Applicable 
polypeptide OTTMUSP00000017290 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002122 Melanocortin 3 receptor
InterPro IPR001671 Melanocortin/ACTH receptor
InterPro IPR001908 Melanocortin receptor
Protein Ontology PR:000001236 melanocortin receptor 3
References (Earliest) J:17785 Desarnaud F, et al., Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene. Biochem J. 1994 Apr 15;299(Pt 2):367-73
(Latest) J:205314 Almodovar AJ, et al., Genomic structure and genetic drift in C57BL/6 congenic metabolic mutant mice. Mol Genet Metab. 2013 Nov;110(3):396-400
All references(71)
Other
accession IDs
MGD-MRK-12131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory