Lmnb1
Gene Detail

Symbol Name ID

Lmnb1 lamin B1 MGI:96795

Feature Type

protein coding gene

Genetic Map

Chromosome 18

30.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr18:56707813-56753424 bp, + strand From VEGA annotation of GRCm38   45612 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lmnb1

Human homologs

Human Homolog		LMNB1, lamin B1
NCBI Gene ID		4001
neXtProt AC		NX_P20700
Human Synonyms		ADLD, LMN, LMN2, LMNB
Human Chr (Location)		5q23.2; chr5:126112315-126172712 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LMNB1

Alleles and phenotypes

All alleles(43) : Targeted(5) Gene trapped(38)
 

Homozygous null mice display neonatal lethality with respiratory distress, abnormal lung, craniofacial, and skeletal morphology, reduced embryo size, impaired cellular proliferation and differentiation, and abnormal nuclear morphology.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M, positive regulation of JNK cascade
Component	intermediate filament, lamin filament, ...
Function	JUN kinase binding, phospholipase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (209)    Tissues (81)    Images (35)
Theiler Stages: 11, 17, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	153
RT-PCR	52

cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(84) cDNA(81) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016318 (Evidence)
Ensembl Gene Model	ENSMUSG00000024590 (Evidence)
Entrez Gene	16906 (Evidence)
UniGene	4105
DFCI	TC1576739, TC1759375
DoTS	DT.496514, DT.94333025
NIA Mouse Gene Index	U158810
Consensus CDS Project	CCDS29261.1
International Mouse Knockout Project Status	Lmnb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016318	VEGA Gene Model | MGI Sequence Detail	45612	C57BL/6J
transcript	OTTMUST00000039218	VEGA | MGI Sequence Detail	2843	Not Applicable
polypeptide	OTTMUSP00000017522	VEGA | MGI Sequence Detail	588	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(160 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR001322	Lamin Tail Domain
Protein Ontology	PR:000009860	lamin-B1

References

(Earliest) J:16564 McKeon FD, et al., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12;319(6053):463-8
(Latest) J:193454 Solovei I, et al., LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation. Cell. 2013 Jan 31;152(3):584-98
All references(79)

Other accession IDs

MGD-MRK-11819