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Lmnb1 Gene Detail
Summary
  • Symbol
    Lmnb1
  • Name
    lamin B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96795
    NCBI Gene: 16906
  • Gene Overview
    MyGene.info: LMNB1
Location & Maps
more
  • Sequence Map
    Chr18:56707813-56753424 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45612 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 30.84 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    LMNB1, lamin B1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMNB1, lamin B1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADLD, LMN, LMN2, LMNB
  • Links
    NCBI Gene ID: 4001
    neXtProt AC: NX_P20700

  • Chr Location
    5q23.2; chr5:126776623-126837020 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55912
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LMNB1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lmnb1 mouse models; 1 with human LMNB1 associations

Human Disease Mouse Models
       Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant; ADLD   OMIM: 169500 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 7 alleles in 7 genetic backgrounds
    39 phenotypes from multigenic genotypes
    2 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with respiratory distress, abnormal lung, craniofacial, and skeletal morphology, reduced embryo size, impaired cellular proliferation and differentiation, and abnormal nuclear morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016318 VEGA Gene Model | MGI Sequence Detail 45612 C57BL/6J ±  kb
transcript OTTMUST00000039218 VEGA | MGI Sequence Detail 2843 Not Applicable  
polypeptide OTTMUSP00000017522 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    211 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 77
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11819
References
more
  • Summaries
    All 88
    Developmental Gene Expression 27
    Diseases 2
    Gene Ontology 14
    Phenotypes 22
  • Earliest
    J:16564 McKeon FD, et al., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12;319(6053):463-8
  • Latest
    J:224310 Ishihara T, et al., Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015 Jan;35(1):211-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory