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Lmnb1
Gene Detail
Symbol

Name
ID
Lmnb1
lamin B1
MGI:96795
Feature Type
protein coding gene
Genetic Map
Chromosome 18
30.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr18:56707813-56753424 bp, + strand
From VEGA annotation of GRCm38

  45612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LMNB1
Gene Tree: Lmnb1

Human
homologs
LMNB1, lamin B1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4001
neXtProt AC: NX_P20700

Human Synonyms: ADLD, LMN, LMN2, LMNB

Human Chr (Location): 5q23.2; chr5:126776623-126837020 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LMNB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(38) Targeted(8) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display neonatal lethality with respiratory distress, abnormal lung, craniofacial, and skeletal morphology, reduced embryo size, impaired cellular proliferation and differentiation, and abnormal nuclear morphology.
 
Human Diseases Modeled in Mice Using Lmnb1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Lmnb1 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (24 records)
Data Summary: Results (209)    Tissues (82)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 153
RT-PCR 52
cDNA source data(76)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lmnb1 ; ZFIN lmnb1    NEW 
Molecular
reagents
All nucleic(80) cDNA(77) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016318 (Evidence)
Ensembl Gene Model ENSMUSG00000024590 (Evidence)
Entrez Gene 16906 (Evidence)
UniGene 4105
DFCI TC1576739, TC1759375
DoTS DT.496514, DT.94333025
NIA Mouse Gene Index U158810
Consensus CDS Project CCDS29261.1
International Mouse Phenotyping Consortium Status Lmnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016318 VEGA Gene Model | MGI Sequence Detail 45612 C57BL/6J ±  kb
transcript OTTMUST00000039218 VEGA | MGI Sequence Detail 2843 Not Applicable 
polypeptide OTTMUSP00000017522 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR001322 Lamin Tail Domain
Protein Ontology PR:000009860 lamin-B1
References
(Earliest) J:16564 McKeon FD, et al., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12;319(6053):463-8
(Latest) J:220857 Bartoletti-Stella A, et al., Messenger RNA processing is altered in autosomal dominant leukodystrophydagger. Hum Mol Genet. 2015 May 15;24(10):2746-56
All references(86)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory