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Lmnb1
Gene Detail
 Symbol
Name
ID
Lmnb1
lamin B1
MGI:96795
Feature Type protein coding gene
Genetic Map
Chromosome 18
30.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr18:56707813-56753424 bp, + strand
From VEGA annotation of GRCm38

  45612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55912  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lmnb1

Human
homologs
Human Homolog LMNB1, lamin B1
NCBI Gene ID 4001
neXtProt AC  NX_P20700
Human Synonyms  ADLD, LMN, LMN2, LMNB
Human Chr (Location)  5q23.2; chr5:126776623-126837020 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LMNB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(38) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with respiratory distress, abnormal lung, craniofacial, and skeletal morphology, reduced embryo size, impaired cellular proliferation and differentiation, and abnormal nuclear morphology.
 
Phenotype Images(2)
Interactions
Lmnb1 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle, positive regulation of JNK cascade
Component intermediate filament, lamin filament, ...
Function JUN kinase binding, phospholipase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (209)    Tissues (81)    Images (35)
Theiler Stages: 11, 17, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 153
RT-PCR 52
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(77) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016318 (Evidence)
Ensembl Gene ModelENSMUSG00000024590 (Evidence)
Entrez Gene16906 (Evidence)
UniGene4105
DFCITC1576739, TC1759375
DoTSDT.496514, DT.94333025
NIA Mouse Gene IndexU158810
Consensus CDS ProjectCCDS29261.1
International Mouse Knockout Project StatusLmnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016318 VEGA Gene Model | MGI Sequence Detail 45612 C57BL/6J ±  kb
transcript OTTMUST00000039218 VEGA | MGI Sequence Detail 2843 Not Applicable 
polypeptide OTTMUSP00000017522 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR001322 Lamin Tail Domain
Protein Ontology PR:000009860 lamin-B1
References (Earliest) J:16564 McKeon FD, et al., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12;319(6053):463-8
(Latest) J:197315 Jung HJ, et al., Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
All references(84)
Other
accession IDs
MGD-MRK-11819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory