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Lmnb1 Gene Detail
Summary
  • Symbol
    Lmnb1
  • Name
    lamin B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96795
    NCBI Gene: 16906
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:56840885-56886496 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 30.84 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96795
protein coding gene Chr18:56840885-56886496 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024444
protein coding gene Chr18:56099013-56147357 (+)
A/J MGP_AJ_G0024410
protein coding gene Chr18:53874700-53921886 (+)
AKR/J MGP_AKRJ_G0024380
protein coding gene Chr18:55355833-55402705 (+)
BALB/cJ MGP_BALBcJ_G0024410
protein coding gene Chr18:54057784-54104178 (+)
C3H/HeJ MGP_C3HHeJ_G0024177
protein coding gene Chr18:55574607-55623573 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024856
protein coding gene Chr18:57881097-57933321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022288
protein coding gene Chr18:53507379-53550059 (+)
CAST/EiJ MGP_CASTEiJ_G0023651
protein coding gene Chr18:55587992-55633901 (+)
CBA/J MGP_CBAJ_G0024147
protein coding gene Chr18:59692124-59744602 (+)
DBA/2J MGP_DBA2J_G0024277
protein coding gene Chr18:53571755-53618198 (+)
FVB/NJ MGP_FVBNJ_G0024244
protein coding gene Chr18:52962809-53010373 (+)
LP/J MGP_LPJ_G0024362
protein coding gene Chr18:56053442-56105204 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024274
protein coding gene Chr18:61356179-61405280 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024903
protein coding gene Chr18:55482637-55533697 (+)
PWK/PhJ MGP_PWKPhJ_G0023395
protein coding gene Chr18:53592868-53639080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023201
protein coding gene Chr18:55547581-55594554 (+)
WSB/EiJ MGP_WSBEiJ_G0023714
protein coding gene Chr18:55400397-55448257 (+)



Homology
more
  • Human Ortholog
    LMNB1, lamin B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMNB1, lamin B1
  • Synonyms
    ADLD, LMN, LMN2, LMNB, MCPH26
  • Links
    NCBI Gene ID: 4001
    neXtProt AC: NX_P20700
    UniProt: P20700

  • Chr Location
    5q23.2; chr5:126776623-126837020 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human LMNB1 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with respiratory distress, abnormal lung, craniofacial, and skeletal morphology, reduced embryo size, impaired cellular proliferation and differentiation, and abnormal nuclear morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16906 NCBI Gene Model | MGI Sequence Detail 45612 C57BL/6J ±  kb
    transcript NM_010721 RefSeq | MGI Sequence Detail 2871 ZRU/MplStud  
    polypeptide P14733 UniProt | EBI | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 78
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11819
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 58
      Diseases 1
      Gene Ontology 19
      Phenotypes 35
    • Earliest
      J:16564 McKeon FD, et al., Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12;319(6053):463-8
    • Latest
      J:345312 Mak S, et al., Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory