Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables phospholipase binding activity and sequence-specific double-stranded DNA binding activity. A structural constituent of cytoskeleton. Predicted to be involved in several processes, including cellular response to L-glutamate; nucleus organization; and protein localization to nuclear envelope. Located in nuclear inner membrane and nuclear lumen. Is active in nuclear lamina. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1).