Rr614 Other Genome Feature Detail

Summary

• Symbol
  Rr614
• Name
  regulatory region 614
• Synonyms
  Lmnb1 oligodendrocyte silencer

• Feature Type
  silencer
• IDs
  MGI:8167108
• Cluster Members
  Rr538218, Rr538219, Rr538221 (3 members)
• Regulates expression of
  Lmnb1 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr18:56741063-56760023 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• chr18:56741063-56760023 (GRCm39)

• Genetic Map
  Chromosome 18, Syntenic

Strain
Comparison

• SNPs within 2kb
  832 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:362986 Nmezi B, et al., An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants. Nat Commun. 2025 Feb 5;16(1):1373

Rr614 regulates expression of:

Feature	Feature Type	Location	Reference
Lmnb1, lamin B1	protein coding gene	Chr18:56840885-56886496 (+)	J:362986

Rr614 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr538218, regulatory region 538218	enhancer	Chr18:56741838-56742230
Rr538219, regulatory region 538219	enhancer	Chr18:56753786-56754333
Rr538221, regulatory region 538221	enhancer	Chr18:56755298-56756012