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Lgals3 Gene Detail
Summary
  • Symbol
    Lgals3
  • Name
    lectin, galactose binding, soluble 3
  • Synonyms
    gal3, galectin-3, L-34, Mac-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96778
    NCBI Gene: 16854
  • Gene Overview
    MyGene.info: LGALS3
Location & Maps
more
  • Sequence Map
    Chr14:47367751-47386160 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18410 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LGALS3, lectin, galactoside binding soluble 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LGALS3, lectin, galactoside binding soluble 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2
  • Links
    NCBI Gene ID: 3958
    neXtProt AC: NX_P17931

  • Chr Location
    14q22.3; chr14:55129217-55145430 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lgals3 mouse models

Human Disease Mouse Models
       Fatty Liver Disease, Nonalcoholic, Susceptibility to, 1; NAFLD1   OMIM: 613282 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 2 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    14
  • Targeted
    6
  • Genomic Mutations
    1 involving Lgals3
  • Incidental Mutations
    APF
Homozygotes for a null allele show susceptibility to S. pneumoniae infection, resistance to renal fibrosis, defects in chondrocyte differentiation, and impaired macrophage activation. Homozygotes for another null allele show altered peritoneal inflammation, and susceptibility to T. gondii infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032779 VEGA Gene Model | MGI Sequence Detail 18410 C57BL/6J ±  kb
transcript OTTMUST00000081619 VEGA | MGI Sequence Detail 1419 Not Applicable  
polypeptide OTTMUSP00000043688 VEGA | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    211 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009771 galectin-3
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR015534 Galectin-3
    IPR001079 Galectin, carbohydrate recognition domain
Molecular
Reagents
less
  • All nucleic 309
    Genomic 5
    cDNA 300
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11797
References
more
  • Summaries
    All 166
    Developmental Gene Expression 19
    Diseases 3
    Gene Ontology 13
    Phenotypes 91
  • Earliest
    J:17163 Jia S, et al., Carbohydrate binding protein 35. Complementary DNA sequence reveals homology with proteins of the heterogeneous nuclear RNP. J Biol Chem. 1988 May 5;263(13):6009-11
  • Latest
    J:228186 Burguillos MA, et al., Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. Cell Rep. 2015 Mar 4;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory