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Lgals3
Gene Detail
Symbol

Name
ID
Lgals3
lectin, galactose binding, soluble 3
MGI:96778
Synonyms
gal3, galectin-3, L-34, Mac-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
24.60 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:47367751-47386160 bp, + strand
From VEGA annotation of GRCm38

  18410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37608  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LGALS3
Protein SuperFamily: galectin 3
Gene Tree: Lgals3

Human
homologs
LGALS3, lectin, galactoside-binding, soluble, 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3958
neXtProt AC: NX_P17931

Human Synonyms: CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2

Human Chr (Location): 14q22.3; chr14:55129217-55145430 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(14) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a null allele show susceptibility to S. pneumoniae infection, resistance to renal fibrosis, defects in chondrocyte differentiation, and impaired macrophage activation. Homozygotes for another null allele show altered peritoneal inflammation, and susceptibility to T. gondii infection.
 
Human Diseases Modeled in Mice Using Lgals3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Lgals3 interacts with 58 markers (Mir16-1, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process cell differentiation, eosinophil chemotaxis, ...
Component cell surface, cytoplasm, ...
Function advanced glycation end-product receptor activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (67)    Tissues (47)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 46
RT-PCR 16
cDNA source data(300)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase lgals3    NEW 
Molecular
reagents
All nucleic(309) Genomic(5) cDNA(300) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000032779 (Evidence)
Ensembl Gene Model ENSMUSG00000050335 (Evidence)
Entrez Gene 16854 (Evidence)
UniGene 248615
DFCI TC1572166
DoTS DT.101356782, DT.110765552, DT.496319, DT.91447814, DT.97335310
NIA Mouse Gene Index U056994
Consensus CDS Project CCDS26986.1
International Mouse Phenotyping Consortium Status Lgals3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032779 VEGA Gene Model | MGI Sequence Detail 18410 C57BL/6J ±  kb
transcript OTTMUST00000081619 VEGA | MGI Sequence Detail 1419 Not Applicable 
polypeptide OTTMUSP00000043688 VEGA | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR015534 Galectin-3
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009771 galectin-3
References
(Earliest) J:17163 Jia S, et al., Carbohydrate binding protein 35. Complementary DNA sequence reveals homology with proteins of the heterogeneous nuclear RNP. J Biol Chem. 1988 May 5;263(13):6009-11
(Latest) J:219662 Baek JH, et al., Galectin-3 activates PPARgamma and supports white adipose tissue formation and high-fat diet-induced obesity. Endocrinology. 2015 Jan;156(1):147-56
All references(155)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11797

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory