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Krt1
Gene Detail
 Symbol
Name
ID
Krt1
keratin 1
MGI:96698
Synonyms Krt-2.1, Krt2-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:101845428-101850786 bp, - strand
From Ensembl annotation of GRCm38

  5359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Krt1

Human
homologs
Human Homolog KRT1, keratin 1
NCBI Gene ID 3848
neXtProt AC  NX_P04264
Human Synonyms  CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK
Human Chr (Location)  12q13.13; chr12:52674736-52680407 (-)  GRCh38
Disease Associations  (6) Diseases Associated with Human KRT1
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Chemically induced(1)
 
Mice heterozygous for a dominant mutation exhibit significant blistering and skin erosions at birth and develop severe hyperkeratosis as adults. Mice homozygous for the dominant mutation also exhibit blistering, and die before weaning age.
 
Human Diseases Modeled Using Mouse Krt1 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process complement activation, lectin pathway, establishment of skin barrier, ...
Component blood microparticle, extracellular space, ...
Function carbohydrate binding, structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (74 records)
Data Summary: Results (54)    Tissues (19)    Images (32)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 12
Northern blot 3
RT-PCR 10
cDNA source data(165)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(175) Genomic(5) cDNA(166) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000046834 (Evidence)
Entrez Gene16678 (Evidence)
UniGene183137
DFCITC1574084
DoTSDT.101376607, DT.87061275, DT.99858060
Consensus CDS ProjectCCDS37221.1
International Mouse Knockout Project StatusKrt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046834 Ensembl Gene Model | MGI Sequence Detail 5359 C57BL/6J ±  kb
transcript ENSMUST00000023790 Ensembl | MGI Sequence Detail 2445 Not Applicable 
polypeptide ENSMUSP00000023790 Ensembl | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009450 keratin, type II cytoskeletal 1
References (Earliest) J:16016 Steinert PM, et al., Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. J Biol Chem. 1985 Jun 10;260(11):7142-9
(Latest) J:201587 Wang D, et al., MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013 Oct;15(10):1153-63
All references(113)
Other
accession IDs
MGD-MRK-11635, MGD-MRK-11653

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory