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Krt1
Gene Detail
Symbol

Name
ID
Krt1
keratin 1
MGI:96698
Synonyms
Krt-2.1, Krt2-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:101845428-101850786 bp, - strand
From Ensembl annotation of GRCm38

  5359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KRT1
Gene Tree: Krt1

Human
homologs
KRT1, keratin 1, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3848
neXtProt AC: NX_P04264

Human Synonyms: CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK

Human Chr (Location): 12q13.13; chr12:52674736-52680407 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human KRT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(3)
Genomic Mutations involving Krt1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice heterozygous for a dominant mutation exhibit significant blistering and skin erosions at birth and develop severe hyperkeratosis as adults. Mice homozygous for the dominant mutation also exhibit blistering, and die before weaning age.
 
Human Diseases Modeled in Mice Using Krt1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Krt1 interacts with 105 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (84 records)
Data Summary: Results (54)    Tissues (20)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 12
Northern blot 3
RT-PCR 10
cDNA source data(165)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(175) Genomic(5) cDNA(166) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000046834 (Evidence)
Entrez Gene 16678 (Evidence)
UniGene 183137
DFCI TC1574084
DoTS DT.101376607, DT.87061275, DT.99858060
Consensus CDS Project CCDS37221.1
International Mouse Phenotyping Consortium Status Krt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046834 Ensembl Gene Model | MGI Sequence Detail 5359 C57BL/6J ±  kb
transcript ENSMUST00000023790 Ensembl | MGI Sequence Detail 2445 Not Applicable 
polypeptide ENSMUSP00000023790 Ensembl | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009450 keratin, type II cytoskeletal 1
References
(Earliest) J:16016 Steinert PM, et al., Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. J Biol Chem. 1985 Jun 10;260(11):7142-9
(Latest) J:218613 Chen J, et al., The ciliopathy gene rpgrip1l is essential for hair follicle development. J Invest Dermatol. 2015 Mar;135(3):701-9
All references(123)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11635, MGD-MRK-11653

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory