Krt1
Gene Detail

Symbol Name ID

Krt1 keratin 1 MGI:96698

Synonyms

Krt-2.1, Krt2-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:101845428-101850786 bp, - strand From Ensembl annotation of GRCm38   5359 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Krt1

Human homologs

Human Homolog		KRT1, keratin 1
NCBI Gene ID		3848
neXtProt AC		NX_P04264
Human Synonyms		CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK
Human Chr (Location)		12q13.13; chr12:53068520-53074191 (-)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human KRT1

Alleles and phenotypes

All alleles(2) : Targeted(1) Chemically induced(1)
 

Mice heterozygous for a dominant mutation exhibit significant blistering and skin erosions at birth and develop severe hyperkeratosis as adults. Mice homozygous for the dominant mutation also exhibit blistering, and die before weaning age.

 
Human Diseases Modeled Using Mouse Krt1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	complement activation, lectin pathway
Component	intermediate filament, keratin filament, ...
Function	carbohydrate binding, structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (51)    Tissues (19)    Images (32)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	11
Northern blot	3
RT-PCR	10

cDNA source data(163)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(172) Genomic(5) cDNA(164) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000046834 (Evidence)
Entrez Gene	16678 (Evidence)
UniGene	183137
DFCI	TC1574084
DoTS	DT.101376607, DT.87061275, DT.99858060
Consensus CDS Project	CCDS37221.1
International Mouse Knockout Project Status	Krt1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000046834	Ensembl Gene Model | MGI Sequence Detail	5359	C57BL/6J
transcript	ENSMUST00000023790	Ensembl | MGI Sequence Detail	2445	Not Applicable
polypeptide	ENSMUSP00000023790	Ensembl | MGI Sequence Detail	637	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009450	keratin, type II cytoskeletal 1

References

(Earliest) J:16016 Steinert PM, et al., Amino acid sequences of mouse and human epidermal type II keratins of Mr 67,000 provide a systematic basis for the structural and functional diversity of the end domains of keratin intermediate filament subunits. J Biol Chem. 1985 Jun 10;260(11):7142-9
(Latest) J:195087 Francis JC, et al., beta-catenin is required for prostate development and cooperates with Pten loss to drive invasive carcinoma. PLoS Genet. 2013 Jan;9(1):e1003180
All references(104)

Other accession IDs

MGD-MRK-11635, MGD-MRK-11653