Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Acts upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Located in keratin filament. Is active in cornified envelope. Is expressed in autopod; nose; skin; and tongue. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis; epidermolytic hyperkeratosis 1; keratosis palmoplantaris striata 3; and nonepidermolytic palmoplantar keratoderma. Orthologous to human KRT1 (keratin 1).