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Krt18
Gene Detail
 Symbol
Name
ID
Krt18
keratin 18
MGI:96692
Synonyms CK18, Endo B, K18, Krt1-18
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.22 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:102028216-102032026 bp, + strand
From NCBI annotation of GRCm38

  3811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Krt18

Human
homologs
Human Homolog KRT18, keratin 18
NCBI Gene ID 3875
neXtProt AC  NX_P05783
Human Synonyms  CYK18, K18
Human Chr (Location)  12q13; chr12:52948871-52952901 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Krt18 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene are viable, fertile, and live normal life spans. They do, however, develop hepatomegaly by 18 months of age.
 
Interactions
Krt18 interacts with 15 markers (Mir26a-2, Mir133a-1, Mir133a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process extrinsic apoptotic signaling pathway, Golgi to plasma membrane CFTR protein transport, ...
Component cell periphery, centriolar satellite, ...
Function poly(A) RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (79 records)
Data Summary: Results (386)    Tissues (147)    Images (40)
Theiler Stages: 3, 5, 13, 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 357
Northern blot 2
RT-PCR 3
RNase protection 2
cDNA source data(487)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(498) Genomic(6) cDNA(489) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000023043 (Evidence)
Entrez Gene16668 (Evidence)
UniGene22479
DFCITC1573241
DoTSDT.537029, DT.97391329
NIA Mouse Gene IndexU016695
Consensus CDS ProjectCCDS27869.1
International Mouse Knockout Project StatusKrt18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16668 NCBI Gene Model | MGI Sequence Detail 3811 C57BL/6J ±  kb
transcript NM_010664 RefSeq | MGI Sequence Detail 1400 C57BL/6 
polypeptide P05784 UniProt | EBI | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR002957 Keratin, type I
Protein Ontology PR:000009458 keratin, type I cytoskeletal 18
Graphical View of Protein Domain Structure
References (Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:208404 Cowley M, et al., Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PLoS Biol. 2014 Feb;12(2):e1001799
All references(126)
Other
accession IDs
MGD-MRK-11647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory