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Krt18 Gene Detail
Summary
  • Symbol
    Krt18
  • Name
    keratin 18
  • Synonyms
    CK18, Endo B, K18, Krt1-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:96692
    NCBI Gene: 16668
Location & Maps
more
  • Sequence Map
    Chr15:102028216-102032026 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3811 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KRT18, keratin 18, type I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KRT18, keratin 18, type I
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CK-18, CYK18, K18
  • Links
    NCBI Gene ID: 3875
    neXtProt AC: NX_P05783

  • Chr Location
    12q13; chr12:52948871-52952901 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    4 involving Krt18
  • Incidental Mutations
Mice homozygous for disruptions in this gene are viable, fertile, and live normal life spans. They do, however, develop hepatomegaly by 18 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16668 NCBI Gene Model | MGI Sequence Detail 3811 C57BL/6J ±  kb
transcript NM_010664 RefSeq | MGI Sequence Detail 1400 C57BL/6  
polypeptide P05784 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009458 keratin, type I cytoskeletal 18
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR002957 Keratin, type I
    IPR027695 Keratin, type I cytoskeletal 18
Molecular
Reagents
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  • All nucleic 499
    Genomic 6
    cDNA 489
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11647
References
more
  • Summaries
    All 124
    Developmental Gene Expression 83
    Diseases 1
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
  • Latest
    J:219800 Lungova V, et al., Ontogeny of the mouse vocal fold epithelium. Dev Biol. 2015 Mar 15;399(2):263-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory