Krt18
Gene Detail

Symbol Name ID

Krt18 keratin 18 MGI:96692

Synonyms

CK18, Endo B, K18, Krt1-18

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.22 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:102028216-102032026 bp, + strand From NCBI annotation of GRCm38   3811 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55448  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Krt18

Human homologs

Human Homolog		KRT18, keratin 18
NCBI Gene ID		3875
neXtProt AC		NX_P05783
Human Synonyms		CYK18, K18
Human Chr (Location)		12q13; chr12:53342655-53346685 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for disruptions in this gene are viable, fertile, and live normal life spans. They do, however, develop hepatomegaly by 18 months of age.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	extrinsic apoptotic signaling pathway, Golgi to plasma membrane CFTR protein transport, ...
Component	centriolar satellite, cytoplasm, ...
Function	protein binding, scaffold protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (71 records)
Data Summary: Results (332)    Tissues (93)    Images (38)
Theiler Stages: 3, 4, 5, 13, 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	299
Northern blot	2
RT-PCR	7
RNase protection	2

cDNA source data(421)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(432) Genomic(6) cDNA(423) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023043 (Evidence)
Entrez Gene	16668 (Evidence)
UniGene	22479
DFCI	TC1573241
DoTS	DT.537029, DT.97391329
NIA Mouse Gene Index	U016695
Consensus CDS Project	CCDS27869.1
International Mouse Knockout Project Status	Krt18

Sequences

Length	Strain/Species
genomic	16668	NCBI Gene Model | MGI Sequence Detail	3811	C57BL/6J
transcript	NM_010664	RefSeq | MGI Sequence Detail	1400	C57BL/6
polypeptide	P05784	UniProt | EBI | MGI Sequence Detail	423	Not Applicable

All sequences(29) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR002957	Keratin, type I
Protein Ontology	PR:000009458	keratin, type I cytoskeletal 18

Graphical View of Protein Domain Structure

References

(Earliest) J:16017 Steinert PM, et al., Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature. 1983 Apr 28;302(5911):794-800
(Latest) J:184713 Haybaeck J, et al., Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model. Lab Invest. 2012 Jun;92(6):857-67
All references(116)

Other accession IDs

MGD-MRK-11647