About   Help   FAQ
Itgb6 Gene Detail
Summary
  • Symbol
    Itgb6
  • Name
    integrin beta 6
  • Synonyms
    2210409C20Rik, 4831415H04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96615
    NCBI Gene: 16420
Location & Maps
more
  • Sequence Map
    Chr2:60598292-60722643 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      124352 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 34.81 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ITGB6, integrin subunit beta 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGB6, integrin subunit beta 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AI1H
  • Links
    NCBI Gene ID: 3694
    neXtProt AC: NX_P18564

  • Chr Location
    2q24.2; chr2:160099666-160200313 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Itgb6 mouse models; 1 with human ITGB6 associations

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807 View 1 model
Emphysema, Hereditary Pulmonary   OMIM: 130700 View 1 model
       Amelogenesis Imperfecta, Type IH; AI1H   OMIM: 616221
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Itgb6
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit baldness associated with macrophage infiltration of skin, exaggerated pulmonary inflammation, and an impaired mucosal mast cell response to nematode infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012790 VEGA Gene Model | MGI Sequence Detail 124352 C57BL/6J ±  kb
transcript OTTMUST00000030865 VEGA | MGI Sequence Detail 2995 Not Applicable  
polypeptide OTTMUSP00000013830 VEGA | MGI Sequence Detail 787 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    855 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11494, MGI:1917381, MGI:1925805
References
more
  • Summaries
    All 61
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
  • Latest
    J:218509 Kim HJ, et al., Patterns of gene expression associated with Pten deficiency in the developing inner ear. PLoS One. 2014;9(6):e97544

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory