Itgb6
Gene Detail

Symbol Name ID

Itgb6 integrin beta 6 MGI:96615

Synonyms

2210409C20Rik, 4831415H04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

34.81 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:60598292-60722643 bp, - strand From VEGA annotation of GRCm38   124352 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb6

Human homologs

Human Homolog		ITGB6, integrin, beta 6
NCBI Gene ID		3694
neXtProt AC		NX_P18564
Human Chr (Location)		2q24.2; chr2:160958233-161056590 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation exhibit baldness associated with macrophage infiltration of skin, exaggerated pulmonary inflammation, and an impaired mucosal mast cell response to nematode infection.

 
Human Diseases Modeled Using Mouse Itgb6 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion, cell-matrix adhesion, ...
Component	integral to membrane, integrin complex, ...
Function	integrin binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (152)    Tissues (25)    Images (22)
Theiler Stages: 19, 22, 23, 25, 28

Assay Type	Results
RNA in situ	145
Northern blot	1
RT-PCR	6

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000012790 (Evidence)
Ensembl Gene Model	ENSMUSG00000026971 (Evidence)
Entrez Gene	16420 (Evidence)
UniGene	98193
DFCI	TC1584641, TC1596665, TC1614238, TC1770157
DoTS	DT.101175104, DT.101714402, DT.40173788, DT.91321808, DT.91404868, DT.91410799
NIA Mouse Gene Index	U022670
Consensus CDS Project	CCDS16060.1
International Mouse Knockout Project Status	Itgb6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012790	VEGA Gene Model | MGI Sequence Detail	124352	C57BL/6J
transcript	OTTMUST00000030629	VEGA | MGI Sequence Detail	4806	Not Applicable
polypeptide	OTTMUSP00000013748	VEGA | MGI Sequence Detail	787	Not Applicable

All sequences(54) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(440 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015436	Integrin beta-6 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR014836	Integrin beta subunit, cytoplasmic domain
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009142	integrin beta-6

References

(Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:195350 Chaen T, et al., Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7(11):e48933
All references(58)

Other accession IDs

MGD-MRK-11494, MGI:1917381, MGI:1925805