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Itgb6
Gene Detail
Symbol

Name
ID
Itgb6
integrin beta 6
MGI:96615
Synonyms
2210409C20Rik, 4831415H04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
34.81 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:60598292-60722643 bp, - strand
From VEGA annotation of GRCm38

  124352 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb6

Human
homologs
Human Homolog ITGB6, integrin, beta 6
NCBI Gene ID 3694
neXtProt AC  NX_P18564
Human Chr (Location)  2q24.2; chr2:160099666-160200313 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit baldness associated with macrophage infiltration of skin, exaggerated pulmonary inflammation, and an impaired mucosal mast cell response to nematode infection.
 
Human Diseases Modeled Using Mouse Itgb6 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Itgb6 interacts with 302 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, cell-matrix adhesion, ...
Component external side of plasma membrane, extracellular vesicular exosome, ...
Function integrin binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (152)    Tissues (25)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
Northern blot 1
RT-PCR 6
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012790 (Evidence)
Ensembl Gene ModelENSMUSG00000026971 (Evidence)
Entrez Gene16420 (Evidence)
UniGene98193
DFCITC1584641, TC1596665, TC1614238, TC1770157
DoTSDT.101175104, DT.101714402, DT.40173788, DT.91321808, DT.91404868, DT.91410799
NIA Mouse Gene IndexU022670
Consensus CDS ProjectCCDS16060.1
International Mouse Knockout Project StatusItgb6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012790 VEGA Gene Model | MGI Sequence Detail 124352 C57BL/6J ±  kb
transcript OTTMUST00000030865 VEGA | MGI Sequence Detail 2995 Not Applicable 
polypeptide OTTMUSP00000013830 VEGA | MGI Sequence Detail 787 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(857 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015436 Integrin beta-6 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR014836 Integrin beta subunit, cytoplasmic domain
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009142 integrin beta-6
References
(Earliest) J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
(Latest) J:205525 Henderson NC, et al., Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24
All references(63)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11494, MGI:1917381, MGI:1925805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory