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Phenotypes Associated with This Genotype
Genotype
MGI:2175082
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

respiratory system
• mice exhibit increased airway responsiveness to acetylcholine
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium
• however, mice do not display any overt signs of lung infection

immune system
• mice exhibit increased airway responsiveness to acetylcholine

integument
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs
• however, by 20 to 30 days hair growth on the head and neck resumes
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
J:33139


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory