Itgb4
Gene Detail

Symbol Name ID

Itgb4 integrin beta 4 MGI:96613

Synonyms

CD104

Feature Type

protein coding gene

Genetic Map

Chromosome 11

80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:115974709-116008412 bp, + strand From VEGA annotation of GRCm38   33704 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: integrin, beta-4 subunit
Gene Tree: Itgb4

Human homologs

Human Homolog		ITGB4, integrin, beta 4
NCBI Gene ID		3691
neXtProt AC		NX_P16144
Human Synonyms		CD104
Human Chr (Location)		17q25; chr17:73717516-73753899 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ITGB4

Alleles and phenotypes

All alleles(10) : Targeted(9) Gene trapped(1)
 

Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence.

 
Human Diseases Modeled Using Mouse Itgb4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell adhesion, cell communication, ...
Component	basal plasma membrane, basement membrane, ...
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (129)    Tissues (67)    Images (32)
Theiler Stages: 13, 17, 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	16
RNA in situ	62
Northern blot	3
Western blot	2
RT-PCR	46

cDNA source data(93)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003650 (Evidence)
Ensembl Gene Model	ENSMUSG00000020758 (Evidence)
Entrez Gene	192897 (Evidence)
UniGene	213873
DFCI	TC1578579, TC1592838, TC1691168
DoTS	DT.101382793, DT.110533056, DT.531008, DT.94314025, DT.94391945
NIA Mouse Gene Index	U013557
Consensus CDS Project	CCDS36376.1
International Mouse Knockout Project Status	Itgb4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003650	VEGA Gene Model | MGI Sequence Detail	33704	C57BL/6J
transcript	OTTMUST00000007886	VEGA | MGI Sequence Detail	5779	Not Applicable
polypeptide	OTTMUSP00000003828	VEGA | MGI Sequence Detail	1818	Not Applicable

All sequences(69) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(79 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR012013	Integrin beta-4 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR012896	Integrin beta subunit, tail
InterPro	IPR003644	Na-Ca exchanger/integrin-beta4
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009140	integrin beta-4

References

(Earliest) J:35643 Kennel SJ, et al., Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989 Sep 15;264(26):15515-21
(Latest) J:192592 Sotiropoulou PA, et al., BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
All references(132)

Other accession IDs

MGD-MRK-11492, MGI:2143962