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Itgb4
Gene Detail
 Symbol
Name
ID
Itgb4
integrin beta 4
MGI:96613
Synonyms CD104
Feature Type protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:115974709-116008412 bp, + strand
From VEGA annotation of GRCm38

  33704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta-4 subunit
Gene Tree: Itgb4

Human
homologs
Human Homolog ITGB4, integrin, beta 4
NCBI Gene ID 3691
neXtProt AC  NX_P16144
Human Synonyms  CD104
Human Chr (Location)  17q25; chr17:75721436-75757818 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human ITGB4
Alleles
and
phenotypes
All alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence.
 
Human Diseases Modeled Using Mouse Itgb4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process autophagy, cell adhesion, ...
Component basal plasma membrane, basement membrane, ...
Function G-protein coupled receptor binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (131)    Tissues (69)    Images (34)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 18
RNA in situ 62
Northern blot 3
Western blot 2
RT-PCR 46
cDNA source data(93)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000003650 (Evidence)
Ensembl Gene ModelENSMUSG00000020758 (Evidence)
Entrez Gene192897 (Evidence)
UniGene213873
DFCITC1578579, TC1592838, TC1691168
DoTSDT.101382793, DT.110533056, DT.531008, DT.94314025, DT.94391945
NIA Mouse Gene IndexU013557
Consensus CDS ProjectCCDS36376.1
International Mouse Knockout Project StatusItgb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003650 VEGA Gene Model | MGI Sequence Detail 33704 C57BL/6J ±  kb
transcript OTTMUST00000007886 VEGA | MGI Sequence Detail 5779 Not Applicable 
polypeptide OTTMUSP00000003828 VEGA | MGI Sequence Detail 1818 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(16) UniProt(6)
Polymorphisms SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR012013 Integrin beta-4 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009140 integrin beta-4
References (Earliest) J:35643 Kennel SJ, et al., Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989 Sep 15;264(26):15515-21
(Latest) J:203995 Lee S, et al., Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev Biol. 2013 Nov 15;383(2):201-13
All references(142)
Other
accession IDs
MGD-MRK-11492, MGI:2143962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory