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Itgb4
Gene Detail
Symbol

Name
ID
Itgb4
integrin beta 4
MGI:96613
Synonyms
CD104
Feature Type
protein coding gene
Genetic Map
Chromosome 11
80.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:115974709-116008412 bp, + strand
From VEGA annotation of GRCm38

  33704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:179  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITGB4
Protein SuperFamily: integrin, beta-4 subunit
Gene Tree: Itgb4

Human
homologs
ITGB4, integrin, beta 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3691
neXtProt AC: NX_P16144

Human Synonyms: CD104

Human Chr (Location): 17q25; chr17:75721342-75757819 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ITGB4

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die shortly after birth with extensive detachment of the epidermis and other squamus epithelia. Stratified tissues lack hemidesmosomes and simple epithelia are also defective in adherence.
 
Human Diseases Modeled in Mice Using Itgb4 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Itgb4 interacts with 125 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process amelogenesis, autophagy, ...
Component basal plasma membrane, basement membrane, ...
Function G-protein coupled receptor binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (142)    Tissues (79)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 62
Northern blot 3
Western blot 2
RT-PCR 57
cDNA source data(93)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itgb4 ; ZFIN itgb4    NEW 
Molecular
reagents
All nucleic(96) cDNA(94) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003650 (Evidence)
Ensembl Gene Model ENSMUSG00000020758 (Evidence)
Entrez Gene 192897 (Evidence)
UniGene 213873
DFCI TC1578579, TC1592838, TC1691168
DoTS DT.101382793, DT.110533056, DT.531008, DT.94314025, DT.94391945
NIA Mouse Gene Index U013557
Consensus CDS Project CCDS36376.1
International Mouse Phenotyping Consortium Status Itgb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003650 VEGA Gene Model | MGI Sequence Detail 33704 C57BL/6J ±  kb
transcript OTTMUST00000007886 VEGA | MGI Sequence Detail 5779 Not Applicable 
polypeptide OTTMUSP00000003828 VEGA | MGI Sequence Detail 1818 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(16) UniProt(6)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR012013 Integrin beta-4 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR012896 Integrin beta subunit, tail
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009140 integrin beta-4
References
(Earliest) J:35643 Kennel SJ, et al., Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. J Biol Chem. 1989 Sep 15;264(26):15515-21
(Latest) J:219386 Williams SE, et al., Par3-mInsc and Galphai3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 2014 Aug;16(8):758-69
All references(151)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11492, MGI:2143962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory