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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgb4
integrin beta 4
MGI:96613
31 phenotypes from 7 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgb4tm1.1Mfel/Itgb4tm1.1Mfel
involves: 129S2/SvPas * C57BL/6 		blistering J:137852
Itgb4tm1Efu/Itgb4tm1Efu
involves: 129S1/Sv * 129X1/SvJ 		normal nervous system phenotype J:77644
Itgb4tm1Efu/Itgb4tm1Efu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal epidermis stratum basale morphology J:77644
abnormal epidermis stratum spinosum morphology J:77644
abnormal epidermis suprabasal layer morphology J:77644
abnormal esophageal epithelium morphology J:77644
abnormal skin condition J:77644
abnormal skin physiology J:77644
abnormal tongue epithelium morphology J:77644
blistering J:77644
dermal-epidermal separation J:77644
neonatal lethality, complete penetrance J:77644
respiratory failure J:77644
Itgb4tm1Fgg/Itgb4tm1Fgg
involves: 129S1/Sv * C57BL/6 		abnormal enterocyte proliferation J:48924
abnormal epidermal layer morphology J:48924
abnormal esophageal epithelium morphology J:48924
abnormal skin morphology J:48924
aphagia J:48924
blistering J:48924
decreased keratinocyte adhesion J:48924
dehydration J:48924
dermal-epidermal separation J:48924
perinatal lethality, complete penetrance J:48924
Itgb4tm1Mfel/Itgb4tm1.1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * C57BL/6 * FVB/N 		abnormal myelin sheath morphology J:137852
normal behavior/neurological phenotype J:137852
Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * C57BL/6 * FVB/N 		abnormal myelin sheath morphology J:137852
normal behavior/neurological phenotype J:137852
Itgb4tm1Son/Itgb4tm1Son
129P2/OlaHsd-Itgb4tm1Son 		abnormal cornea morphology J:33713
abnormal keratinocyte morphology J:33713
abnormal nail morphology J:33713
abnormal olfactory epithelium morphology J:33713
abnormal skin condition J:33713
abnormal tongue epithelium morphology J:33713
abnormal urinary bladder urothelium morphology J:33713
dermal-epidermal separation J:33713
edema J:33713
normal immune system phenotype J:33713
neonatal lethality, complete penetrance J:33713
normal nervous system phenotype J:33713
Itgb4tm2Fgg/Itgb4tm2Fgg
involves: 129/Sv * C57BL/6 		decreased angiogenesis J:94627
normal integument phenotype J:94627
Itgb4tm2Son/Itgb4tm2Son
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		abnormal keratinocyte morphology J:96543
blistering J:96543
ear inflammation J:96543
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory