Symbol
Name
ID

Itgb4
integrin beta 4
MGI:96613

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Oral mucosal blisters

Recurrent skin infections

Anonychia

Nail dysplasia

Nail dystrophy

Abnormal blistering of the skin

Lamina lucida cleavage

Hypoplastic dermoepidermal hemidesmosomes

Fragile skin

Aplasia cutis congenita

Aplasia cutis congenita on trunk or limbs

Atrophic scars

Milia

Pterygium

Axillary pterygium

Disease(s) Associated with ITGB4

junctional epidermolysis bullosa with pyloric atresia

Mouse Phenotypes

integument phenotype

decreased keratinocyte adhesion

abnormal nail morphology

abnormal skin morphology

abnormal epidermal layer morphology

abnormal epidermis stratum basale morphology

abnormal epidermis stratum spinosum morphology

abnormal epidermis suprabasal layer morphology

abnormal keratinocyte morphology

dermal-epidermal separation

blistering

abnormal skin condition

abnormal skin physiology

Availability

Mouse Genotype

Itgb4^tm1.1Mfel/Itgb4^tm1.1Mfel

Itgb4^tm1Efu/Itgb4^tm1Efu

Itgb4^tm1Fgg/Itgb4^tm1Fgg

Itgb4^tm1Son/Itgb4^tm1Son

Itgb4^tm2Fgg/Itgb4^tm2Fgg

Itgb4^tm2Son/Itgb4^tm2Son
Tg(KRT14-cre)8Brn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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