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Itgav
Gene Detail
 Symbol
Name
ID
Itgav
integrin alpha V
MGI:96608
Synonyms 1110004F14Rik, 2610028E01Rik, alphav-integrin, CD51, D430040G12Rik, vitronectin receptor alpha polypeptide (VNRA)
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:83724397-83806916 bp, + strand
From VEGA annotation of GRCm38

  82520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20510  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itgav

Human
homologs
Human Homolog ITGAV, integrin, alpha V
NCBI Gene ID 3685
neXtProt AC  NX_P06756
Human Synonyms  CD51, MSK8, VNRA, VTNR
Human Chr (Location)  2q31-q32; chr2:186589645-186680902 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(3) Targeted(10)
Genomic Mutations involving Itgav (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth.
 
Interactions
Itgav interacts with 370 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process angiogenesis, apoptotic cell clearance, ...
Component alphav-beta3 integrin-IGF-1-IGF1R complex, cell surface, ...
Function insulin-like growth factor I binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (164)    Tissues (25)    Images (26)
Theiler Stages: 14, 20, 22, 23, 28
Assay TypeResults
RNA in situ 150
RT-PCR 14
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(160) cDNA(157) Primer pair(2) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000013360 (Evidence)
Ensembl Gene ModelENSMUSG00000027087 (Evidence)
Entrez Gene16410 (Evidence)
UniGene227
DFCITC1583434, TC1606152, TC1610440, TC1613040, TC1630599, TC1631200, TC1631622, TC1700428
DoTSDT.101132261, DT.101323055, DT.101712721, DT.492179, DT.55186843, DT.91293780, DT.91378700, DT.91424478, DT.94384293
NIA Mouse Gene IndexU042324, U226225
Consensus CDS ProjectCCDS16181.1
International Mouse Knockout Project StatusItgav
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013360 VEGA Gene Model | MGI Sequence Detail 82520 C57BL/6J ±  kb
transcript OTTMUST00000032292 VEGA | MGI Sequence Detail 7054 Not Applicable 
polypeptide OTTMUSP00000014341 VEGA | MGI Sequence Detail 1044 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009135 integrin alpha-V
References (Earliest) J:10951 Moulder K, et al., The mouse vitronectin receptor is a T cell activation antigen. J Exp Med. 1991 Feb 1;173(2):343-7
(Latest) J:205525 Henderson NC, et al., Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24
All references(108)
Other
accession IDs
MGD-MRK-11487, MGI:1923548, MGI:1923608, MGI:2445000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory