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Itgav Gene Detail
Summary
  • Symbol
    Itgav
  • Name
    integrin alpha V
  • Synonyms
    1110004F14Rik, 2610028E01Rik, alphav-integrin, CD51, D430040G12Rik, vitronectin receptor alpha polypeptide (VNRA)
  • Feature Type
    protein coding gene
  • IDs
    MGI:96608
    NCBI Gene: 16410
  • Gene Overview
    MyGene.info: ITGAV
Location & Maps
more
  • Sequence Map
    Chr2:83724397-83806916 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.33 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ITGAV, integrin subunit alpha V
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGAV, integrin subunit alpha V
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD51, MSK8, VNRA, VTNR
  • Links
    NCBI Gene ID: 3685
    neXtProt AC: NX_P06756

  • Chr Location
    2q32.1; chr2:186590063-186680902 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 3 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    10
  • Genomic Mutations
    3 involving Itgav
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013360 VEGA Gene Model | MGI Sequence Detail 82520 C57BL/6J ±  kb
transcript OTTMUST00000032292 VEGA | MGI Sequence Detail 7054 Not Applicable  
polypeptide OTTMUSP00000014341 VEGA | MGI Sequence Detail 1044 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    427 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 161
    cDNA 158
    Primer pair 2
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-11487, MGI:1923548, MGI:1923608, MGI:2445000
References
more
  • Summaries
    All 113
    Developmental Gene Expression 29
    Gene Ontology 23
    Phenotypes 27
  • Earliest
    J:10951 Moulder K, et al., The mouse vitronectin receptor is a T cell activation antigen. J Exp Med. 1991 Feb 1;173(2):343-7
  • Latest
    J:229618 Murphy PA, et al., Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. PLoS One. 2015;10(3):e0120872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory