Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Acts upstream of or within blood vessel development. Located in external side of plasma membrane. Part of integrin alphav-beta5 complex and integrin alphav-beta6 complex. Is expressed in several structures, including early conceptus; embryo mesenchyme; jaw; skeletal muscle; and ventricular layer. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V).