Il2ra
Gene Detail

Symbol Name ID

Il2ra interleukin 2 receptor, alpha chain MGI:96549

Synonyms

CD25, Il2r, IL-2R alpha chain, Ly-43

Feature Type

protein coding gene

Genetic Map

Chromosome 2

8.91 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr2:11642792-11693191 bp, + strand From VEGA annotation of GRCm38   50400 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-2 receptor, alpha chain
Gene Tree: Il2ra

Human homologs

Human Homolog		IL2RA, interleukin 2 receptor, alpha
NCBI Gene ID		3559
neXtProt AC		NX_P01589
Human Synonyms		CD25, IDDM10, IL2R, TCGFR
Human Chr (Location)		10p15-p14; chr10:6052657-6104333 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL2RA

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	activation-induced cell death of T cells, inflammatory response to antigenic stimulus, ...
Component	cell surface, external side of plasma membrane, ...
Function	drug binding, interleukin-2 binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (7)    Tissues (6)   
Theiler Stages: 14, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	1
RT-PCR	6

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(27) Primer pair(2) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011179 (Evidence)
Ensembl Gene Model	ENSMUSG00000026770 (Evidence)
Entrez Gene	16184 (Evidence)
UniGene	915
DFCI	TC1583506, TC1620781, TC1623982
DoTS	DT.101404632, DT.101407850, DT.55163851, DT.55165761, DT.91585178, DT.94126023, DT.94212315
Consensus CDS Project	CCDS15685.1
International Mouse Knockout Project Status	Il2ra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011179	VEGA Gene Model | MGI Sequence Detail	50400	C57BL/6J
transcript	OTTMUST00000026233	VEGA | MGI Sequence Detail	4425	Not Applicable
polypeptide	OTTMUSP00000012002	VEGA | MGI Sequence Detail	268	Not Applicable

All sequences(43) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(3) : SNPs(222 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR015486	Interleukin-2 receptor alpha chain
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000001380	interleukin-2 receptor subunit alpha

References

(Earliest) J:7554 Ortega G, et al., The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984 Oct;133(4):1970-5
(Latest) J:191719 Li J, et al., Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 2013 Jan 15;190(2):597-604
All references(180)

Other accession IDs

MGD-MRK-11375, MGD-MRK-11376, MGD-MRK-11985