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Il2ra
Gene Detail
Symbol

Name
ID
Il2ra
interleukin 2 receptor, alpha chain
MGI:96549
Synonyms
CD25, Il2r, IL-2R alpha chain, Ly-43
Feature Type
protein coding gene
Genetic Map
Chromosome 2
8.91 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:11642807-11693193 bp, + strand
From VEGA annotation of GRCm38

  50387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL2RA
Protein SuperFamily: interleukin-2 receptor, alpha chain
Gene Tree: Il2ra

Human
homologs
IL2RA, interleukin 2 receptor, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3559
neXtProt AC: NX_P01589

Human Synonyms: CD25, IDDM10, IL2R, p55, TCGFR

Human Chr (Location): 10p15-p14; chr10:6010694-6062370 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IL2RA

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.
 
Interactions
Il2ra interacts with 325 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process activation-induced cell death of T cells, immune response, ...
Component cell surface, external side of plasma membrane, ...
Function drug binding, interleukin-2 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (7)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(27) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011179 (Evidence)
Ensembl Gene Model ENSMUSG00000026770 (Evidence)
Entrez Gene 16184 (Evidence)
UniGene 915
DFCI TC1583506, TC1620781, TC1623982
DoTS DT.101404632, DT.101407850, DT.55163851, DT.55165761, DT.91585178, DT.94126023, DT.94212315
Consensus CDS Project CCDS15685.1
International Mouse Phenotyping Consortium Status Il2ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011179 VEGA Gene Model | MGI Sequence Detail 50387 C57BL/6J ±  kb
transcript OTTMUST00000026233 VEGA | MGI Sequence Detail 4412 Not Applicable 
polypeptide OTTMUSP00000012002 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015486 Interleukin-2 receptor alpha chain
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001380 interleukin-2 receptor subunit alpha
References
(Earliest) J:7554 Ortega G, et al., The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984 Oct;133(4):1970-5
(Latest) J:213438 Workman AM, et al., Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells. PLoS One. 2014;9(2):e89010
All references(185)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11375, MGD-MRK-11376, MGD-MRK-11985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory