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Il2ra Gene Detail
Summary
  • Symbol
    Il2ra
  • Name
    interleukin 2 receptor, alpha chain
  • Synonyms
    CD25, Il2r, IL-2R alpha chain, Ly-43
  • Feature Type
    protein coding gene
  • IDs
    MGI:96549
    NCBI Gene: 16184
  • Gene Overview
    MyGene.info: IL2RA
Location & Maps
more
  • Sequence Map
    Chr2:11642807-11693193 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50387 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 8.91 cM, cytoband A2-A3
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    IL2RA, interleukin 2 receptor subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL2RA, interleukin 2 receptor subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD25, IDDM10, IL2R, IMD41, p55, TCGFR
  • Links
    NCBI Gene ID: 3559
    neXtProt AC: NX_P01589

  • Chr Location
    10p15-p14; chr10:6010694-6062370 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Il2ra mouse models; 2 with human IL2RA associations

Human Disease Mouse Models
       Immunodeficiency 41 with Lymphoproliferation and Autoimmunity; IMD41   OMIM: 606367 View 1 "NOT" model
       Diabetes Mellitus, Insulin-Dependent, 10; IDDM10   OMIM: 601942
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 2 genetic backgrounds
    22 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    2
  • Targeted
    5
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011179 VEGA Gene Model | MGI Sequence Detail 50387 C57BL/6J ±  kb
transcript OTTMUST00000026233 VEGA | MGI Sequence Detail 4412 Not Applicable  
polypeptide OTTMUSP00000012002 VEGA | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    235 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001380 interleukin-2 receptor subunit alpha
  • InterPro Domains
    IPR015486 Interleukin-2 receptor alpha
    IPR000436 Sushi/SCR/CCP domain
Molecular
Reagents
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  • All nucleic 31
    cDNA 27
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11375, MGD-MRK-11376, MGD-MRK-11985
References
more
  • Summaries
    All 194
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 36
    Phenotypes 79
  • Earliest
    J:7554 Ortega G, et al., The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984 Oct;133(4):1970-5
  • Latest
    J:233696 Coursey TG, et al., Interferon-gamma-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjogren Syndrome. Am J Pathol. 2016 Jun;186(6):1547-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory