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Il2ra
Gene Detail
Symbol

Name
ID
Il2ra
interleukin 2 receptor, alpha chain
MGI:96549
Synonyms
CD25, Il2r, IL-2R alpha chain, Ly-43
Feature Type
protein coding gene
Genetic Map
Chromosome 2
8.91 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:11642792-11693191 bp, + strand
From VEGA annotation of GRCm38

  50400 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-2 receptor, alpha chain
Gene Tree: Il2ra

Human
homologs
Human Homolog IL2RA, interleukin 2 receptor, alpha
NCBI Gene ID 3559
neXtProt AC  NX_P01589
Human Synonyms  CD25, IDDM10, IL2R, p55, TCGFR
Human Chr (Location)  10p15-p14; chr10:6010694-6062370 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human IL2RA
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit massive proliferation of polyclonal T and B cells as adults and develop autoimmune disorders including inflammatory bowel disease and hemolytic anemia with age.
 
Interactions
Il2ra interacts with 326 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process activation-induced cell death of T cells, immune response, ...
Component cell surface, external side of plasma membrane, ...
Function drug binding, interleukin-2 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (7)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 6
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(27) Primer pair(2) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011179 (Evidence)
Ensembl Gene ModelENSMUSG00000026770 (Evidence)
Entrez Gene16184 (Evidence)
UniGene915
DFCITC1583506, TC1620781, TC1623982
DoTSDT.101404632, DT.101407850, DT.55163851, DT.55165761, DT.91585178, DT.94126023, DT.94212315
Consensus CDS ProjectCCDS15685.1
International Mouse Knockout Project StatusIl2ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011179 VEGA Gene Model | MGI Sequence Detail 50400 C57BL/6J ±  kb
transcript OTTMUST00000026233 VEGA | MGI Sequence Detail 4425 Not Applicable 
polypeptide OTTMUSP00000012002 VEGA | MGI Sequence Detail 268 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(3) : SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015486 Interleukin-2 receptor alpha chain
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000001380 interleukin-2 receptor subunit alpha
References
(Earliest) J:7554 Ortega G, et al., The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J Immunol. 1984 Oct;133(4):1970-5
(Latest) J:213438 Workman AM, et al., Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells. PLoS One. 2014;9(2):e89010
All references(190)
Other
accession IDs
MGD-MRK-11375, MGD-MRK-11376, MGD-MRK-11985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory