About   Help   FAQ
Il1rn
Gene Detail
Symbol

Name
ID
Il1rn
interleukin 1 receptor antagonist
MGI:96547
STS
Synonyms
F630041P17Rik, IL-1ra
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:24336853-24351494 bp, + strand
From VEGA annotation of GRCm38

  14642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interleukin-1
Gene Tree: Il1rn

Human
homologs
Human Homolog IL1RN, interleukin 1 receptor antagonist
NCBI Gene ID 3557
neXtProt AC  NX_P18510
Human Synonyms  DIRA, ICIL-1RA, IL1F3, IL-1ra, IL1RA, IL-1ra3, IL-1RN, IRAP, MVCD4
Human Chr (Location)  2q14.2; chr2:113117893-113134016 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human IL1RN
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.
 
Interactions
Il1rn interacts with 235 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(3) cDNA(25) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011966 (Evidence)
Ensembl Gene ModelENSMUSG00000026981 (Evidence)
Entrez Gene16181 (Evidence)
UniGene882
DFCITC1575079, TC1632112, TC1663882, TC1684436
DoTSDT.101372120, DT.94237348, DT.97365240
NIA Mouse Gene IndexU001468
Consensus CDS ProjectCCDS15736.1, CCDS38064.1, CCDS50520.1
International Mouse Knockout Project StatusIl1rn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011966 VEGA Gene Model | MGI Sequence Detail 14642 C57BL/6J ±  kb
transcript OTTMUST00000028284 VEGA | MGI Sequence Detail 1986 Not Applicable 
polypeptide OTTMUSP00000012802 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(8) UniProt(11)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
InterPro IPR027166 Interleukin-1 receptor antagonist protein
Protein Ontology PR:000001137 interleukin-1 receptor antagonist protein
References
(Earliest) J:14587 Eisenberg SP, et al., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990 Jan 25;343(6256):341-6
(Latest) J:213353 Yang EJ, et al., EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control. PLoS One. 2014;9(2):e86062
All references(124)
Other
accession IDs
MGD-MRK-11373, MGI:2443250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory