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Il1rn Gene Detail
Summary
  • Symbol
    Il1rn
  • Name
    interleukin 1 receptor antagonist
  • Synonyms
    F630041P17Rik, IL-1ra
  • Feature Type
    protein coding gene
  • IDs
    MGI:96547
    NCBI Gene: 16181
Location & Maps
more
  • Sequence Map
    Chr2:24336853-24351494 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14642 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL1RN, interleukin 1 receptor antagonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1RN, interleukin 1 receptor antagonist
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIRA, ICIL-1RA, IL1F3, IL-1ra, IL1RA, IL-1ra3, IL-1RN, IRAP, MVCD4
  • Links
    NCBI Gene ID: 3557
    neXtProt AC: NX_P18510

  • Chr Location
    2q14.2; chr2:113099365-113134016 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human IL1RN associations

Human Disease Mouse Models
       Gastric Cancer, Hereditary Diffuse; HDGC   OMIM: 137215
Microvascular Complications of Diabetes, Susceptibility to, 4; MVCD4   OMIM: 612628
Osteomyelitis, Sterile Multifocal, with Periostitis and Pustulosis;   OMIM: 612852
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 13 genetic backgrounds
    27 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    7
  • Transgenic
    4
  • Incidental Mutations
    APF
Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011966 VEGA Gene Model | MGI Sequence Detail 14642 C57BL/6J ±  kb
transcript OTTMUST00000028284 VEGA | MGI Sequence Detail 1986 Not Applicable  
polypeptide OTTMUSP00000012802 VEGA | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001137 interleukin-1 receptor antagonist protein
  • InterPro Domains
    IPR008996 Cytokine, IL-1-like
    IPR020877 Interleukin-1 conserved site
    IPR000975 Interleukin-1 family
    IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
    IPR027166 Interleukin-1 receptor antagonist protein
Molecular
Reagents
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  • All nucleic 31
    Genomic 3
    cDNA 25
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11373, MGI:2443250
References
more
  • Summaries
    All 125
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 6
    Phenotypes 69
  • Earliest
    J:14587 Eisenberg SP, et al., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990 Jan 25;343(6256):341-6
  • Latest
    J:227783 Wakabayashi C, et al., IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging. Neurosci Lett. 2015 Jul 10;599:20-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory