Il1rn
Gene Detail

Symbol Name ID

Il1rn interleukin 1 receptor antagonist MGI:96547

STS

D2Mit60

Synonyms

F630041P17Rik, IL-1ra

Feature Type

protein coding gene

Genetic Map

Chromosome 2

16.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr2:24336853-24351494 bp, + strand From VEGA annotation of GRCm38   14642 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-1
Gene Tree: Il1rn

Human homologs

Human Homolog		IL1RN, interleukin 1 receptor antagonist
NCBI Gene ID		3557
neXtProt AC		NX_P18510
Human Synonyms		DIRA, ICIL-1RA, IL1F3, IL-1ra, IL1RA, IL-1ra3, IL-1RN, IRAP, MVCD4
Human Chr (Location)		2q14.2; chr2:113875470-113891593 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human IL1RN

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	acute-phase response, fever generation, ...
Component	centrosome, cytoplasm, ...
Function	interleukin-1 receptor antagonist activity, interleukin-1 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(3) cDNA(25) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000011966 (Evidence)
Ensembl Gene Model	ENSMUSG00000026981 (Evidence)
Entrez Gene	16181 (Evidence)
UniGene	882
DFCI	TC1575079, TC1632112, TC1663882, TC1684436
DoTS	DT.101372120, DT.94237348, DT.97365240
NIA Mouse Gene Index	U001468
Consensus CDS Project	CCDS15736.1, CCDS38064.1, CCDS50520.1
International Mouse Knockout Project Status	Il1rn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011966	VEGA Gene Model | MGI Sequence Detail	14642	C57BL/6J
transcript	OTTMUST00000028284	VEGA | MGI Sequence Detail	1986	Not Applicable
polypeptide	OTTMUSP00000012802	VEGA | MGI Sequence Detail	178	Not Applicable

All sequences(68) RefSeq(6) UniProt(6)

Polymorphisms

All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR000975	Interleukin-1
InterPro	IPR020877	Interleukin-1 conserved site
InterPro	IPR003297	Interleukin-1 receptor antagonist / Interleukin-36
InterPro	IPR027166	Interleukin-1 receptor antagonist protein
Protein Ontology	PR:000001137	interleukin-1 receptor antagonist protein

References

(Earliest) J:14587 Eisenberg SP, et al., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990 Jan 25;343(6256):341-6
(Latest) J:195718 Vecile E, et al., Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes. PLoS One. 2013;8(1):e53265
All references(118)

Other accession IDs

MGD-MRK-11373, MGI:2443250