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Il1rn Gene Detail
Summary
  • Symbol
    Il1rn
  • Name
    interleukin 1 receptor antagonist
  • Synonyms
    F630041P17Rik, IL-1ra
  • Feature Type
    protein coding gene
  • IDs
    MGI:96547
    NCBI Gene: 16181
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:24336860-24351491 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.36 cM
  • Mapping Data
    12 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96547
protein coding gene Chr2:24336853-24351494 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025408
protein coding gene Chr2:22136602-22152805 (+)
A/J MGP_AJ_G0025385
protein coding gene Chr2:21280713-21295350 (+)
AKR/J MGP_AKRJ_G0025355
protein coding gene Chr2:22013161-22027800 (+)
BALB/cJ MGP_BALBcJ_G0025381
protein coding gene Chr2:21391263-21405906 (+)
C3H/HeJ MGP_C3HHeJ_G0025142
protein coding gene Chr2:21948917-21964245 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025825
protein coding gene Chr2:22844313-22858893 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023236
protein coding gene Chr2:20210763-20225753 (+)
CAST/EiJ MGP_CASTEiJ_G0024605
protein coding gene Chr2:21779510-21795870 (+)
CBA/J MGP_CBAJ_G0025120
protein coding gene Chr2:23651297-23668121 (+)
DBA/2J MGP_DBA2J_G0025253
protein coding gene Chr2:21140102-21155537 (+)
FVB/NJ MGP_FVBNJ_G0025215
protein coding gene Chr2:20880422-20895108 (+)
LP/J MGP_LPJ_G0025339
protein coding gene Chr2:22066444-22080768 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025246
protein coding gene Chr2:23887376-23904374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025884
protein coding gene Chr2:21939271-21955685 (+)
PWK/PhJ MGP_PWKPhJ_G0024353
protein coding gene Chr2:20923446-20938711 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024153
protein coding gene Chr2:22059063-22074564 (+)
WSB/EiJ MGP_WSBEiJ_G0024674
protein coding gene Chr2:22008317-22023929 (+)



Homology
more
  • Human Ortholog
    IL1RN, interleukin 1 receptor antagonist
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IL1RN, interleukin 1 receptor antagonist
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIRA, ICIL-1RA, IL1F3, IL-1ra, IL1RA, IL-1ra3, IL-1RN, IRAP, MVCD4
  • Links
    NCBI Gene ID: 3557
    neXtProt AC: NX_P18510
    UniProt: P18510

  • Chr Location
    2q14.1; chr2:113099365-113134016 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IL1RN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 6 alleles in 13 genetic backgrounds
    27 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16181 NCBI Gene Model | MGI Sequence Detail 14632 C57BL/6J ±  kb
transcript NM_001039701 RefSeq | MGI Sequence Detail 2480 C57BL/6  
polypeptide P25085 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 3
    cDNA 26
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11373, MGI:2443250
References
more
  • Summaries
    All 155
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 7
    Phenotypes 80
  • Earliest
    J:14587 Eisenberg SP, et al., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990 Jan 25;343(6256):341-6
  • Latest
    J:277253 Rogier R, et al., Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice. PLoS One. 2019;14(7):e0219366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory