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Il1rn
Gene Detail
Symbol

Name
ID
Il1rn
interleukin 1 receptor antagonist
MGI:96547
STS
Synonyms
F630041P17Rik, IL-1ra
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr2:24336853-24351494 bp, + strand
From VEGA annotation of GRCm38

  14642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11163  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IL1RN
Protein SuperFamily: interleukin-1
Gene Tree: Il1rn

Human
homologs
IL1RN, interleukin 1 receptor antagonist
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3557
neXtProt AC: NX_P18510

Human Synonyms: DIRA, ICIL-1RA, IL1F3, IL-1ra, IL1RA, IL-1ra3, IL-1RN, IRAP, MVCD4

Human Chr (Location): 2q14.2; chr2:113099365-113134016 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human IL1RN

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(7) Transgenic(2)
Incidental mutations (data from APF )
 
Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Il1rn interacts with 235 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process acute-phase response, cytokine-mediated signaling pathway, ...
Component cell, cytoplasm, ...
Function cytokine activity, interleukin-1 receptor antagonist activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(3) cDNA(25) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011966 (Evidence)
Ensembl Gene Model ENSMUSG00000026981 (Evidence)
Entrez Gene 16181 (Evidence)
UniGene 882
DFCI TC1575079, TC1632112, TC1663882, TC1684436
DoTS DT.101372120, DT.94237348, DT.97365240
NIA Mouse Gene Index U001468
Consensus CDS Project CCDS15736.1, CCDS38064.1, CCDS50520.1
International Mouse Phenotyping Consortium Status Il1rn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011966 VEGA Gene Model | MGI Sequence Detail 14642 C57BL/6J ±  kb
transcript OTTMUST00000028284 VEGA | MGI Sequence Detail 1986 Not Applicable 
polypeptide OTTMUSP00000012802 VEGA | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(6)
Polymorphisms
All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR020877 Interleukin-1 conserved site
InterPro IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
InterPro IPR027166 Interleukin-1 receptor antagonist protein
Protein Ontology PR:000001137 interleukin-1 receptor antagonist protein
References
(Earliest) J:14587 Eisenberg SP, et al., Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature. 1990 Jan 25;343(6256):341-6
(Latest) J:217209 Cottle DL, et al., Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet. 2015 Jan 15;24(2):436-49
All references(126)
Other
accession IDs
MGD-MRK-11373, MGI:2443250

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory