About   Help   FAQ
Il1r1
Gene Detail
Symbol

Name
ID
Il1r1
interleukin 1 receptor, type I
MGI:96545
STS
Synonyms
CD121a, Il1r-1, IL-1R1, IL-1 receptor alpha chain, IL-iR
Feature Type
protein coding gene
Genetic Map
Chromosome 1
18.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr1:40225080-40317257 bp, + strand
From VEGA annotation of GRCm38

  92178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IL1R1
Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1r1

Human
homologs
IL1R1, interleukin 1 receptor, type I
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3554
neXtProt AC: NX_P14778

Human Synonyms: CD121A, D2S1473, IL1R, IL1RA, IL-1R-alpha, P80

Human Chr (Location): 2q12; chr2:102069638-102179874 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, reduced IL1b responsiveness, delayed tooth eruption, decreased susceptibility to experimental autoimmune uveoritinitis, decreased susceptibility to kidney reperfusion injury, and late onset obesity.
 
Human Diseases Modeled in Mice Using Il1r1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Il1r1 interacts with 315 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cytokine-mediated signaling pathway, heat acclimation, ...
Component axon, cell surface, ...
Function interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (52)    Tissues (33)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 26
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase il1r1    NEW 
Molecular
reagents
All nucleic(34) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050518 (Evidence)
Ensembl Gene Model ENSMUSG00000026072 (Evidence)
Entrez Gene 16177 (Evidence)
UniGene 896
DFCI TC1589552, TC1615604
DoTS DT.110944994, DT.530909, DT.91316539
NIA Mouse Gene Index U000195
PDB 1OU3
Consensus CDS Project CCDS35547.1, CCDS48246.1
International Mouse Phenotyping Consortium Status Il1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050518 VEGA Gene Model | MGI Sequence Detail 92178 C57BL/6J ±  kb
transcript OTTMUST00000128132 VEGA | MGI Sequence Detail 5819 Not Applicable 
polypeptide OTTMUSP00000068975 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(28) UniProt(4)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(694 from dbSNP Build 137)    SNPs within 2kb including multiple locations(706)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR004076 Interleukin-1 receptor IL1R
InterPro IPR004074 Interleukin-1 receptor, type I/II
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001363 interleukin-1 receptor type I
References
(Earliest) J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
(Latest) J:219864 Liu X, et al., Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. J Neurosci. 2015 Feb 18;35(7):2860-70
All references(411)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11369, MGD-MRK-11371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory