Il1r1
Gene Detail

Symbol Name ID

Il1r1 interleukin 1 receptor, type I MGI:96545

STS

D1Nds6

Synonyms

CD121a, Il1r-1, IL-1 receptor alpha chain, IL-iR

Feature Type

protein coding gene

Genetic Map

Chromosome 1

18.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr1:40225080-40316177 bp, + strand From NCBI annotation of GRCm38   91098 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1r1

Human homologs

Human Homolog		IL1R1, interleukin 1 receptor, type I
NCBI Gene ID		3554
neXtProt AC		NX_P14778
Human Synonyms		CD121A, D2S1473, IL1R, IL1RA, IL-1R-alpha, P80
Human Chr (Location)		2q12; chr2:102770402-102796334 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, reduced IL1b responsiveness, delayed tooth eruption, decreased susceptibility to experimental autoimmune uveoritinitis, decreased susceptibility to kidney reperfusion injury, and late onset obesity.

 
Human Diseases Modeled Using Mouse Il1r1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cytokine-mediated signaling pathway, interleukin-1-mediated signaling pathway, ...
Component	cell surface, extracellular region, ...
Function	interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (36)    Images (2)
Theiler Stages: 2, 3, 4, 17, 19, 20, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	24
RT-PCR	33

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(27) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026072 (Evidence)
Entrez Gene	16177 (Evidence)
UniGene	896
DFCI	TC1589552, TC1615604
DoTS	DT.110944994, DT.530909, DT.91316539
NIA Mouse Gene Index	U000195
PDB	1OU3
Consensus CDS Project	CCDS35547.1, CCDS48246.1
International Mouse Knockout Project Status	Il1r1

Sequences

Length	Strain/Species
genomic	16177	NCBI Gene Model | MGI Sequence Detail	91098	C57BL/6J
transcript	NM_001123382	RefSeq | MGI Sequence Detail	4808	C57BL/6
polypeptide	P13504	UniProt | EBI | MGI Sequence Detail	576	Not Applicable

All sequences(26) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(626 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR015621	Interleukin-1 receptor family
InterPro	IPR004076	Interleukin-1 receptor IL1R
InterPro	IPR004074	Interleukin-1 receptor, type I/II
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology	PR:000001363	interleukin-1 receptor type I

Graphical View of Protein Domain Structure

References

(Earliest) J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
(Latest) J:195858 Nov O, et al., Interleukin-1beta regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS One. 2013;8(1):e53626
All references(362)

Other accession IDs

MGD-MRK-11369, MGD-MRK-11371