About   Help   FAQ
Il1r1
Gene Detail
Symbol

Name
ID
Il1r1
interleukin 1 receptor, type I
MGI:96545
STS
Synonyms
CD121a, Il1r-1, IL-1R1, IL-1 receptor alpha chain, IL-iR
Feature Type
protein coding gene
Genetic Map
Chromosome 1
18.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr1:40225080-40317257 bp, + strand
From VEGA annotation of GRCm38

  92178 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1r1

Human
homologs
Human Homolog   IL1R1, interleukin 1 receptor, type I
NCBI Gene ID 3554
neXtProt AC  NX_P14778
Human Synonyms  CD121A, D2S1473, IL1R, IL1RA, IL-1R-alpha, P80
Human Chr (Location)  2q12; chr2:102070376-102179874 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, reduced IL1b responsiveness, delayed tooth eruption, decreased susceptibility to experimental autoimmune uveoritinitis, decreased susceptibility to kidney reperfusion injury, and late onset obesity.
 
Human Diseases Modeled in Mice Using Il1r1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Il1r1 interacts with 315 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cytokine-mediated signaling pathway, heat acclimation, ...
Component axon, cell surface, ...
Function interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (52)    Tissues (33)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 26
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000050518 (Evidence)
Ensembl Gene ModelENSMUSG00000026072 (Evidence)
Entrez Gene16177 (Evidence)
UniGene896
DFCITC1589552, TC1615604
DoTSDT.110944994, DT.530909, DT.91316539
NIA Mouse Gene IndexU000195
PDB1OU3
Consensus CDS ProjectCCDS35547.1, CCDS48246.1
International Mouse Knockout Project StatusIl1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050518 VEGA Gene Model | MGI Sequence Detail 92178 C57BL/6J ±  kb
transcript OTTMUST00000128132 VEGA | MGI Sequence Detail 5819 Not Applicable 
polypeptide OTTMUSP00000068975 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(28) UniProt(4)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(694 from dbSNP Build 137)    SNPs within 2kb including multiple locations(706)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR004076 Interleukin-1 receptor IL1R
InterPro IPR004074 Interleukin-1 receptor, type I/II
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001363 interleukin-1 receptor type I
References
(Earliest) J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
(Latest) J:217693 Scheeren FA, et al., A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol. 2014 Dec;16(12):1238-48
All references(410)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11369, MGD-MRK-11371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/17/2015
MGI 5.21
The Jackson Laboratory