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Il1r1
Gene Detail
 Symbol
Name
ID
Il1r1
interleukin 1 receptor, type I
MGI:96545
STS D1Nds6
Synonyms CD121a, Il1r-1, IL-1 receptor alpha chain, IL-iR
Feature Type protein coding gene
Genetic Map
Chromosome 1
18.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr1:40225080-40316177 bp, + strand
From NCBI annotation of GRCm38

  91098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: interleukin-1 receptor type I
Gene Tree: Il1r1

Human
homologs
Human Homolog IL1R1, interleukin 1 receptor, type I
NCBI Gene ID 3554
neXtProt AC  NX_P14778
Human Synonyms  CD121A, D2S1473, IL1R, IL1RA, IL-1R-alpha, P80
Human Chr (Location)  2q12; chr2:102070376-102179874 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection, reduced IL1b responsiveness, delayed tooth eruption, decreased susceptibility to experimental autoimmune uveoritinitis, decreased susceptibility to kidney reperfusion injury, and late onset obesity.
 
Human Diseases Modeled Using Mouse Il1r1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cytokine-mediated signaling pathway, heat acclimation, ...
Component axon, cell surface, ...
Function interleukin-1 receptor activity, interleukin-1, Type I, activating receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (59)    Tissues (36)    Images (2)
Theiler Stages: 2, 3, 4, 17, 19, 20, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 33
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) cDNA(29) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026072 (Evidence)
Entrez Gene16177 (Evidence)
UniGene896
DFCITC1589552, TC1615604
DoTSDT.110944994, DT.530909, DT.91316539
NIA Mouse Gene IndexU000195
PDB1OU3
Consensus CDS ProjectCCDS35547.1, CCDS48246.1
International Mouse Knockout Project StatusIl1r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16177 NCBI Gene Model | MGI Sequence Detail 91098 C57BL/6J ±  kb
transcript NM_001123382 RefSeq | MGI Sequence Detail 4808 C57BL/6 
polypeptide P13504 UniProt | EBI | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(26) UniProt(4)
Polymorphisms All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(685 from dbSNP Build 137)    SNPs within 2kb including multiple locations(697)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR004076 Interleukin-1 receptor IL1R
InterPro IPR004074 Interleukin-1 receptor, type I/II
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001363 interleukin-1 receptor type I
Graphical View of Protein Domain Structure
References (Earliest) J:22685 Sims JE, et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science. 1988 Jul 29;241(4865):585-9
(Latest) J:209984 Hara K, et al., Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol. 2014 May 1;192(9):4032-42
All references(396)
Other
accession IDs
MGD-MRK-11369, MGD-MRK-11371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory