Symbol
Name
ID

Il1r1
interleukin 1 receptor, type I
MGI:96545

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormality of chromosome stability	Chromosome breakage	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Hyperglycemia	Diabetes mellitus	Ketoacidosis	Edema	Fever
Disease(s) Associated with IL1R1	Abnormality of chromosome stability	Chromosome breakage	Decreased level of 1,5 anhydroglucitol in serum	Elevated circulating C-reactive protein concentration	Elevated erythrocyte sedimentation rate	Hyperglycemia	Diabetes mellitus	Ketoacidosis	Edema	Fever
chronic recurrent multifocal osteomyelitis
systemic scleroderma
type 1 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal vascular wound healing

decreased circulating creatinine level

decreased blood urea nitrogen level

increased circulating insulin level

increased circulating insulin-like growth factor I level

increased circulating leptin level

decreased circulating sodium level

increased circulating interleukin-1 beta level

decreased circulating interleukin-18 level

increased circulating interleukin-18 level

decreased circulating interleukin-6 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

decreased circulating serum amyloid protein level

impaired febrile response

increased respiratory quotient

impaired glucose tolerance

insulin resistance

decreased circulating chloride level

decreased transforming growth factor beta level

abnormal response/metabolism to endogenous compounds

decreased incidence of tumors by chemical induction

decreased susceptibility to kidney reperfusion injury

enhanced wound healing

Availability

Mouse Genotype

Il1r1^{em1(IMPC)Ccpcz}/Il1r1^{em1(IMPC)Ccpcz}

Il1r1^em1Qizh/Il1r1^em1Qizh

Il1r1^tm1Imx/Il1r1^tm1Imx

Il1r1^tm1Roml/Il1r1^tm1Roml

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23